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Protein

CTP synthase 2

Gene

Ctps2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).By similarity

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase (Ctps1), CTP synthase 2 (Ctps2)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei399For GATase activityBy similarity1
Active sitei526For GATase activityBy similarity1
Active sitei528For GATase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-499943 Interconversion of nucleotide di- and triphosphates
UniPathwayiUPA00159; UER00277

Protein family/group databases

MEROPSiC26.964

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthase 2 (EC:6.3.4.2)
Alternative name(s):
CTP synthetase 2
UTP--ammonia ligase 2
Gene namesi
Name:Ctps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1563369 Ctps2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470351 – 586CTP synthase 2Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei568PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2N0
PRIDEiQ5U2N0

PTM databases

iPTMnetiQ5U2N0
PhosphoSitePlusiQ5U2N0

Expressioni

Gene expression databases

BgeeiENSRNOG00000004257
GenevisibleiQ5U2N0 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055810

Structurei

3D structure databases

ProteinModelPortaliQ5U2N0
SMRiQ5U2N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 554Glutamine amidotransferase type-1Add BLAST255

Sequence similaritiesi

Belongs to the CTP synthase family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG2387 Eukaryota
COG0504 LUCA
GeneTreeiENSGT00910000144179
HOGENOMiHOG000077514
HOVERGENiHBG002243
InParanoidiQ5U2N0
KOiK01937
OMAiFSEPRIA
OrthoDBiEOG091G03OK
PhylomeDBiQ5U2N0
TreeFamiTF300379

Family and domain databases

CDDicd01746 GATase1_CTP_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_01227 PyrG, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR004468 CTP_synthase
IPR017456 CTP_synthase_N
IPR017926 GATASE
IPR033828 GATase1_CTP_Synthase
IPR027417 P-loop_NTPase
PANTHERiPTHR11550 PTHR11550, 1 hit
PfamiView protein in Pfam
PF06418 CTP_synth_N, 1 hit
PF00117 GATase, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00337 PyrG, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U2N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF
60 70 80 90 100
SPYEHGEVFV LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK
110 120 130 140 150
ERRGDYLGKT VQVVPHITDA IQDWVMNQAK VSVDGNKEDP QICVIELGGT
160 170 180 190 200
IGDIEGMAFV EAFRQFQFKA KRENFYNIHV SLVPQPSATG EQKTKPTQNS
210 220 230 240 250
VRALRGLGLS PDLIVCRSST PIEMAVKEKI SMFCHVNPEQ VICIHDVSSI
260 270 280 290 300
YRVPLLLEEQ GVVKYFQERL DLPINDCSNN LLFKWKTMAD RYERLQKICS
310 320 330 340 350
IALVGKYTKL RDCYASVFKA LEHSALAINH KLNLMYIDSI DLEPVTKAED
360 370 380 390 400
PVKFHEAWQK LCLADGILVP GGFGIRGTLG KLQAISWART KKIPFLGICL
410 420 430 440 450
GMQLAVIEFA RNCLNLKDAN STEFDPNTPV PLVIDMPEHN PGDLGGTMRL
460 470 480 490 500
GLRRTVFTTE NSILKKLYGD VPYIEERHRH RYEVNPNLIN QFENKDLCFV
510 520 530 540 550
GEDVDGKRME IIELTGHPYF IGVQFHPEFS SRPMKPSPPY LGLLLAATGT
560 570 580
LNTHLQQMSK LSYSDIYSDA SDDSFSEAKF AELDIN
Length:586
Mass (Da):65,674
Last modified:December 7, 2004 - v1
Checksum:iA67D001E9C3E8D3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085949 mRNA Translation: AAH85949.1
BC085358 mRNA Translation: AAH85358.1
RefSeqiNP_001030170.1, NM_001034998.2
XP_006256958.1, XM_006256896.2
XP_006256959.1, XM_006256897.3
XP_006256960.1, XM_006256898.3
XP_006256961.1, XM_006256899.3
XP_006256962.1, XM_006256900.2
UniGeneiRn.13683

Genome annotation databases

EnsembliENSRNOT00000059031; ENSRNOP00000055810; ENSRNOG00000004257
GeneIDi619580
KEGGirno:619580
UCSCiRGD:1563369 rat

Similar proteinsi

Entry informationi

Entry nameiPYRG2_RAT
AccessioniPrimary (citable) accession number: Q5U2N0
Secondary accession number(s): Q5U3X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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