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Protein

CTP synthase 2

Gene

Ctps2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).By similarity

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase (Ctps1), CTP synthase 2 (Ctps2)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei399For GATase activityBy similarity1
Active sitei526For GATase activityBy similarity1
Active sitei528For GATase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
UniPathwayiUPA00159; UER00277.

Protein family/group databases

MEROPSiC26.964.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthase 2 (EC:6.3.4.2)
Alternative name(s):
CTP synthetase 2
UTP--ammonia ligase 2
Gene namesi
Name:Ctps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1563369. Ctps2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470351 – 586CTP synthase 2Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei568PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2N0.
PRIDEiQ5U2N0.

PTM databases

iPTMnetiQ5U2N0.
PhosphoSitePlusiQ5U2N0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004257.
GenevisibleiQ5U2N0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055810.

Structurei

3D structure databases

ProteinModelPortaliQ5U2N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 554Glutamine amidotransferase type-1Add BLAST255

Sequence similaritiesi

Belongs to the CTP synthase family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG2387. Eukaryota.
COG0504. LUCA.
GeneTreeiENSGT00390000012473.
HOGENOMiHOG000077514.
HOVERGENiHBG002243.
InParanoidiQ5U2N0.
KOiK01937.
OMAiQNANGHA.
OrthoDBiEOG091G03OK.
PhylomeDBiQ5U2N0.
TreeFamiTF300379.

Family and domain databases

CDDicd01746. GATase1_CTP_Synthase. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR033828. GATase1_CTP_Synthase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF
60 70 80 90 100
SPYEHGEVFV LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK
110 120 130 140 150
ERRGDYLGKT VQVVPHITDA IQDWVMNQAK VSVDGNKEDP QICVIELGGT
160 170 180 190 200
IGDIEGMAFV EAFRQFQFKA KRENFYNIHV SLVPQPSATG EQKTKPTQNS
210 220 230 240 250
VRALRGLGLS PDLIVCRSST PIEMAVKEKI SMFCHVNPEQ VICIHDVSSI
260 270 280 290 300
YRVPLLLEEQ GVVKYFQERL DLPINDCSNN LLFKWKTMAD RYERLQKICS
310 320 330 340 350
IALVGKYTKL RDCYASVFKA LEHSALAINH KLNLMYIDSI DLEPVTKAED
360 370 380 390 400
PVKFHEAWQK LCLADGILVP GGFGIRGTLG KLQAISWART KKIPFLGICL
410 420 430 440 450
GMQLAVIEFA RNCLNLKDAN STEFDPNTPV PLVIDMPEHN PGDLGGTMRL
460 470 480 490 500
GLRRTVFTTE NSILKKLYGD VPYIEERHRH RYEVNPNLIN QFENKDLCFV
510 520 530 540 550
GEDVDGKRME IIELTGHPYF IGVQFHPEFS SRPMKPSPPY LGLLLAATGT
560 570 580
LNTHLQQMSK LSYSDIYSDA SDDSFSEAKF AELDIN
Length:586
Mass (Da):65,674
Last modified:December 7, 2004 - v1
Checksum:iA67D001E9C3E8D3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085949 mRNA. Translation: AAH85949.1.
BC085358 mRNA. Translation: AAH85358.1.
RefSeqiNP_001030170.1. NM_001034998.2.
XP_006256958.1. XM_006256896.2.
XP_006256959.1. XM_006256897.3.
XP_006256960.1. XM_006256898.3.
XP_006256961.1. XM_006256899.3.
XP_006256962.1. XM_006256900.2.
UniGeneiRn.13683.

Genome annotation databases

EnsembliENSRNOT00000059031; ENSRNOP00000055810; ENSRNOG00000004257.
GeneIDi619580.
KEGGirno:619580.
UCSCiRGD:1563369. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085949 mRNA. Translation: AAH85949.1.
BC085358 mRNA. Translation: AAH85358.1.
RefSeqiNP_001030170.1. NM_001034998.2.
XP_006256958.1. XM_006256896.2.
XP_006256959.1. XM_006256897.3.
XP_006256960.1. XM_006256898.3.
XP_006256961.1. XM_006256899.3.
XP_006256962.1. XM_006256900.2.
UniGeneiRn.13683.

3D structure databases

ProteinModelPortaliQ5U2N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055810.

Protein family/group databases

MEROPSiC26.964.

PTM databases

iPTMnetiQ5U2N0.
PhosphoSitePlusiQ5U2N0.

Proteomic databases

PaxDbiQ5U2N0.
PRIDEiQ5U2N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000059031; ENSRNOP00000055810; ENSRNOG00000004257.
GeneIDi619580.
KEGGirno:619580.
UCSCiRGD:1563369. rat.

Organism-specific databases

CTDi56474.
RGDi1563369. Ctps2.

Phylogenomic databases

eggNOGiKOG2387. Eukaryota.
COG0504. LUCA.
GeneTreeiENSGT00390000012473.
HOGENOMiHOG000077514.
HOVERGENiHBG002243.
InParanoidiQ5U2N0.
KOiK01937.
OMAiQNANGHA.
OrthoDBiEOG091G03OK.
PhylomeDBiQ5U2N0.
TreeFamiTF300379.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.
ReactomeiR-RNO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiQ5U2N0.

Gene expression databases

BgeeiENSRNOG00000004257.
GenevisibleiQ5U2N0. RN.

Family and domain databases

CDDicd01746. GATase1_CTP_Synthase. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR033828. GATase1_CTP_Synthase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRG2_RAT
AccessioniPrimary (citable) accession number: Q5U2N0
Secondary accession number(s): Q5U3X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.