Reviewed, UniProtKB/Swiss-Prot Q5U263 (JHD1A_XENTR)

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1A
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1A
    F-box and leucine-rich repeat protein 11
    F-box/LRR-repeat protein 11

Gene names

Name:	fbxl11
Synonyms:	jhdm1a

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	1146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylted H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation By similarity.
Catalytic activity	Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2). Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
Cofactor	Binds 1 Fe(2+) ion per subunit By similarity.
Subcellular location	NucleusBy similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 CXXC-type zinc finger. Contains 1 F-box domain. Contains 1 JmjC domain. Contains 3 LRR (leucine-rich) repeats. Contains 1 PHD-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Leucine-rich repeat Repeat Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1146	1146	JmjC domain-containing histone demethylation protein 1A		PRO_0000226787
Regions
	Domain	146 – 314	169	JmjC
	Domain	874 – 919	46	F-box
	Repeat	984 – 1009	26	LRR 1
	Repeat	1047 – 1075	29	LRR 2
	Repeat	1079 – 1102	24	LRR 3
	Zinc finger	585 – 631	47	CXXC-type
	Zinc finger	638 – 699	62	PHD-type
Sites
	Metal binding	210	1	Iron; catalytic By similarity
	Metal binding	212	1	Iron; catalytic By similarity
	Metal binding	282	1	Iron; catalytic By similarity
	Binding site	207	1	Substrate By similarity
	Binding site	227	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5U263-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: C2812F2A5FD45816	FASTA	1,146	131,750
	10 20 30 40 50 60 MEEEQLRYSR RLRHTLRRRY EDDGISDDEI EGKRTFDLEE KLRSSKYNSN FITYMEGKDF 70 80 90 100 110 120 NMKFIQEGGL RDPIIFTKSE GLGIKMPDPN FSVNDVKMFV GSRRVVDVMD VGTQKGIEMT 130 140 150 160 170 180 MAQWAKYYET PEEEREKLYN VISLEFSHTK LENLVQRPTT VDQIDWVDNI WPRHLKDRQT 190 200 210 220 230 240 ESTNVIQEMQ YPKVQKYCLM SVRGCYTDFH VDFGGTSVWY HILRGGKVFW LIPPTDQNLE 250 260 270 280 290 300 LYENWLLSGK QGDVFLGDRV TECQRIELKQ GYTFVIPSGW IHAVYTPQDT LVFGGNFLHS 310 320 330 340 350 360 FNIPMQLRIY SIEDRTRVPT KFRYPFYYEM CWYVLERYVY CMMRRSHLTK EFQRESLSID 370 380 390 400 410 420 LELNGRQRPD TPSSSSSSSS SGLSSSSDND DSSDQDWEEE EGLRKRERDR CRVERELQRK 430 440 450 460 470 480 RNRDRQQRDQ ERDRHGRTER IIIHTLPASL RPLTPPPSLP LPTPDSPPST SPFLTWFEVE 490 500 510 520 530 540 GLRCLVLKLE SLPPLKKCLP DGIHDPEALI FDIKRLLEDH AHDPPELALT GVPIIQWPKR 550 560 570 580 590 600 SQYKVHLRPK IQFTKPHTMR PASRHSTAPP RTSGTPSGTT ASSGARRRRV RCRKCQACVQ 610 620 630 640 650 660 RECGTCHYCK DMKKFGGPGR MKQSCVLRQC LAPRLPHSVT CALCGEVDQT NDTQDFERKL 670 680 690 700 710 720 MECSVCNEIV HPGCLEMDGE GLLSDELPNY WECPKCYEGQ KHTVEANHDR ILLHSKRKAA 730 740 750 760 770 780 DNYESSHYYP AKVLRPPLGQ SPPSPPLLLL PPSPSSAPPT PPSAQTQVPL ASREERAKRR 790 800 810 820 830 840 QLAREKENHP TGCDQSEGDR LRLRGPYLTV TLQRPPKELS STSIVPKLQA ITPNPRQPIR 850 860 870 880 890 900 AAPLHQDEER EEEEEEEEEE EETENVMLGQ RKDSTSMQKD VWLSVFHYLT HEELCICMRV 910 920 930 940 950 960 CKAWYKWGCD KRLWSRIDVS RCKSLVPQAL SGIIKRQPIY LDLSWTNVSK KQLIWLINRL 970 980 990 1000 1010 1020 PGLKDLILAG CTWSAVSALA SCSCPLLRTL DLRWTVGIKD TQIRDLLTPA SDKSGHDSRS 1030 1040 1050 1060 1070 1080 KLRLLTDLRL SGLDISDVTL RLIIRHCPLL SKLDLSHCPL LSDQSVNLLT AVGSSTRGTL 1090 1100 1110 1120 1130 1140 THIHLAGCKG VTDESLLYLR RATNLSLIDL HGCKQVTRGA CEEFISDLSV STLYCLSDDK LIQRIS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC086264 mRNA. Translation: AAH86264.1.
RefSeq	NP_001011176.1.
UniGene	Str.11178
3D structure databases
SMR	Q5U263. Positions 34-362.
ModBase	Search...
Genome annotation databases
Ensembl	ENSXETG00000015793. Xenopus tropicalis. [Contig view]
GeneID	496596.
KEGG	xtr:496596.
Organism-specific databases
Xenbase	XB-FEAT-5900837. fbxl11.
Phylogenomic databases
HOVERGEN	Q5U263.
Family and domain databases
InterPro	IPR001810. F-box. IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR002857. Znf_CXXC. IPR001965. Znf_PHD. [Graphical view]
Pfam	PF00646. F-box. 1 hit. PF02373. JmjC. 1 hit. PF00628. PHD. 1 hit. PF02008. zf-CXXC. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
PROSITE	PS50181. FBOX. False negative. PS51184. JMJC. 1 hit. PS51058. ZF_CXXC. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

JHD1A_XENTR

Accession

Primary (citable) accession number: Q5U263

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	December 7, 2004
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project