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Q5U258

- GCNT3_XENLA

UniProt

Q5U258 - GCNT3_XENLA

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Protein

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

Gene

gcnt3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans (By similarity).By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.

Pathwayi

GO - Molecular functioni

  1. beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
  2. N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC:2.4.1.102, EC:2.4.1.150)
Alternative name(s):
C2GnT-mucin type
Short name:
C2GnT-M
Gene namesi
Name:gcnt3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5887147. gcnt3.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3PRO_0000288550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi71 ↔ 228By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi162 ↔ 385By similarity
Disulfide bondi183 ↔ 210By similarity
Disulfide bondi394 ↔ 426By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5U258.
SMRiQ5U258. Positions 68-436.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini34 – 443410LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3318Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 14 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051711.
KOiK09662.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U258 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLMAHVRRK LCRGHLLRCT LPLTLLLFLT VGLKHLAIDC NLAHNNDIPM
60 70 80 90 100
GSCMASYYTA LNLSAPGEKN CHRIIQGDTE EARRALLDNL MVKKRRLVAT
110 120 130 140 150
DGDYINATSD CKFFRERRKY ITFSLSQVEQ DFPIAYSMVI HDNIEMFERL
160 170 180 190 200
LRAVYTPHNI YCVHVDKKSP ESFQQAARAI TSCFDNVFVA SKLESVVYAS
210 220 230 240 250
WRRVQADLNC MEDLLQSNVQ WRYLINTCGT DFPIKTNAEM VKALKSLNGH
260 270 280 290 300
NSMESEIPPN YKKRRWEYHF ELKEDSNKIV QTNTRKKPSP LPVPVFSGNA
310 320 330 340 350
YIVVTRNFVN SLFVNPTAKK FIMWAKDTYS PDEYMWATLH RFAEMPGHMP
360 370 380 390 400
AHQKYDTSDI NAIARLVKWQ SLEGDMNKGA PYIPCTGTHR RQVCVYGTGD
410 420 430 440
LNWMVQQHHF FANKFDPKVD DNAIQCLEEY LRYKTFHPTE NVA
Length:443
Mass (Da):51,202
Last modified:December 7, 2004 - v1
Checksum:i403A28322EC561A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC086270 mRNA. Translation: AAH86270.1.
RefSeqiNP_001088629.1. NM_001095160.1.
UniGeneiXl.49113.

Genome annotation databases

GeneIDi495681.
KEGGixla:495681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC086270 mRNA. Translation: AAH86270.1 .
RefSeqi NP_001088629.1. NM_001095160.1.
UniGenei Xl.49113.

3D structure databases

ProteinModelPortali Q5U258.
SMRi Q5U258. Positions 68-436.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT14. Glycosyltransferase Family 14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495681.
KEGGi xla:495681.

Organism-specific databases

CTDi 9245.
Xenbasei XB-GENE-5887147. gcnt3.

Phylogenomic databases

HOVERGENi HBG051711.
KOi K09662.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR003406. Glyco_trans_14.
[Graphical view ]
Pfami PF02485. Branch. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGCNT3_XENLA
AccessioniPrimary (citable) accession number: Q5U258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3