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Q5U252

- UBP47_XENLA

UniProt

Q5U252 - UBP47_XENLA

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Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene
usp47
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Nucleophile By similarity
Active sitei487 – 4871Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. base-excision repair Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. monoubiquitinated protein deubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene namesi
Name:usp47
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5760104. usp47.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13501350Ubiquitin carboxyl-terminal hydrolase 47PRO_0000408358Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5U252.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 548376USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

HOVERGENiHBG058854.
KOiK11857.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF14560. Ubiquitin_2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U252-1 [UniParc]FASTAAdd to Basket

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MRPGEESQLV PKEIENAADE PRVLCIVQDT TNCKSVNERI TLNLPASTSV     50
KQLYEDVSNK AGYVSSTFSL MWGNGASNTD MAALDPTPDR TLQEAGFEAG 100
KKNFLHLTDK DGEQPQLTSD ESGTADSSGL DDSSQEKFIG PLPREESVAG 150
TSNYVSQNYS YSSLLSKSDT GYVGLVNQAM TCYLNSLLQT LFMTPEFRNA 200
LYKWEFEESE EDPVSSIPYQ LQRLFVLLQT SKKRAIETTD VTRSFGWDSS 250
EAWQQHDVQE LCRVMFDALE QKWKQTEQAD LINQLYQGKL KDYVKCLECG 300
YESWRIDTFL DIPLVIRPYG SNTAFGSMEE ALHAFIQPET LDGPNQYFCE 350
RCKRKCDARK GLKFLHFPYL LTLQLKRFDF DYTSMHRIKL NDRMTFPDEL 400
DMSPFIDMED EKSPQTDSCT DSGAENEGSC HSDQMSNDFS TDDAVDEGIC 450
LETNSNIEKL NKSVAEKNSL YELFSVMVHS GSAAGGHYYA CIKSFADGQW 500
YSFNDQHVSR ITQEDIKKTY GGATGNRGYY SSAFASSTNA YMLMYRLKNP 550
ARNAQFLEAS EFPEHIKLLV QKEQEQEEQE KRQREIERNT CKLKLFCMHP 600
VKQIMMESKL EVHKDKTMKE AVEIANKLMD LEGVIPLDCC RLVKYDEFHD 650
YLERSYEDEE DRTMGYLLGG VKSSYMFDLL LETKRPDQVF QSYKPGEVMV 700
KVYVVDLKTE TVASPVSVRA YLSQTIIEFK QLISKSVDLP PDSMRVILER 750
CYNDLRLLNV ANKTLKAEGF FRSNKVFVES SDSLDHQLVF TDSHLWKLLD 800
RHANTIKLYV SLPEHPRPTA RSVGPKGGGD MNPQEDYCSR AKSVDAILEE 850
STEKLKSLSL QQHQDGGNGD SSKSTEGSDF ENIDSPLNEV DSSGSADNRE 900
LENRILPADP ENNFQPEERS DSDVNNDRST SSVDSDILSS SHSSDTLCNA 950
DGTPIPLANG LDSHSITSSR RSKANDGKKE TWDTAEEDSG TDSEYDESGK 1000
SRGEAQYMYF KAEPHAGEGC LAEGSKCLLV NVDKRITLAA FKQQLESFVG 1050
VPSSQFKVFR VYASNQEFES VRLNETLSSF SDDNKITIRL GRALKKGEYR 1100
VKIFQLLVNE PEPCKFVLDA VFSKGMTVRQ SKEELLPLLR EQCGLDLSID 1150
RFRLRKKTWK NPGTVFLDSH VYENESISSC WEVLLEALDE TEKMKSMSQL 1200
SLFTKRWRPS ELKLDPFKEV VLESNSVEEL RDKICEISAI PLENLEFAKG 1250
RGTFPCDISV LEIHQDLDWN PKVSTLNAWP LYISDDGAVI FYRDKTEEVM 1300
ELTDEQRNEL VKKESSRLQK TGHRVTYSPR KEKALKIYLD GPTNKDSAQD 1350
Length:1,350
Mass (Da):153,261
Last modified:December 7, 2004 - v1
Checksum:iEEABB140B02AF3AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC086278 mRNA. Translation: AAH86278.1.
RefSeqiNP_001088634.1. NM_001095165.1.
UniGeneiXl.49309.

Genome annotation databases

GeneIDi495686.
KEGGixla:495686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC086278 mRNA. Translation: AAH86278.1 .
RefSeqi NP_001088634.1. NM_001095165.1.
UniGenei Xl.49309.

3D structure databases

ProteinModelPortali Q5U252.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495686.
KEGGi xla:495686.

Organism-specific databases

CTDi 55031.
Xenbasei XB-GENE-5760104. usp47.

Phylogenomic databases

HOVERGENi HBG058854.
KOi K11857.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF14560. Ubiquitin_2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiUBP47_XENLA
AccessioniPrimary (citable) accession number: Q5U252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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