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Q5U252 (UBP47_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 47

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene names
Name:usp47
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length1350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP47 subfamily.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13501350Ubiquitin carboxyl-terminal hydrolase 47
PRO_0000408358

Regions

Domain173 – 548376USP

Sites

Active site1821Nucleophile By similarity
Active site4871Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5U252 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: EEABB140B02AF3AE

FASTA1,350153,261
        10         20         30         40         50         60 
MRPGEESQLV PKEIENAADE PRVLCIVQDT TNCKSVNERI TLNLPASTSV KQLYEDVSNK 

        70         80         90        100        110        120 
AGYVSSTFSL MWGNGASNTD MAALDPTPDR TLQEAGFEAG KKNFLHLTDK DGEQPQLTSD 

       130        140        150        160        170        180 
ESGTADSSGL DDSSQEKFIG PLPREESVAG TSNYVSQNYS YSSLLSKSDT GYVGLVNQAM 

       190        200        210        220        230        240 
TCYLNSLLQT LFMTPEFRNA LYKWEFEESE EDPVSSIPYQ LQRLFVLLQT SKKRAIETTD 

       250        260        270        280        290        300 
VTRSFGWDSS EAWQQHDVQE LCRVMFDALE QKWKQTEQAD LINQLYQGKL KDYVKCLECG 

       310        320        330        340        350        360 
YESWRIDTFL DIPLVIRPYG SNTAFGSMEE ALHAFIQPET LDGPNQYFCE RCKRKCDARK 

       370        380        390        400        410        420 
GLKFLHFPYL LTLQLKRFDF DYTSMHRIKL NDRMTFPDEL DMSPFIDMED EKSPQTDSCT 

       430        440        450        460        470        480 
DSGAENEGSC HSDQMSNDFS TDDAVDEGIC LETNSNIEKL NKSVAEKNSL YELFSVMVHS 

       490        500        510        520        530        540 
GSAAGGHYYA CIKSFADGQW YSFNDQHVSR ITQEDIKKTY GGATGNRGYY SSAFASSTNA 

       550        560        570        580        590        600 
YMLMYRLKNP ARNAQFLEAS EFPEHIKLLV QKEQEQEEQE KRQREIERNT CKLKLFCMHP 

       610        620        630        640        650        660 
VKQIMMESKL EVHKDKTMKE AVEIANKLMD LEGVIPLDCC RLVKYDEFHD YLERSYEDEE 

       670        680        690        700        710        720 
DRTMGYLLGG VKSSYMFDLL LETKRPDQVF QSYKPGEVMV KVYVVDLKTE TVASPVSVRA 

       730        740        750        760        770        780 
YLSQTIIEFK QLISKSVDLP PDSMRVILER CYNDLRLLNV ANKTLKAEGF FRSNKVFVES 

       790        800        810        820        830        840 
SDSLDHQLVF TDSHLWKLLD RHANTIKLYV SLPEHPRPTA RSVGPKGGGD MNPQEDYCSR 

       850        860        870        880        890        900 
AKSVDAILEE STEKLKSLSL QQHQDGGNGD SSKSTEGSDF ENIDSPLNEV DSSGSADNRE 

       910        920        930        940        950        960 
LENRILPADP ENNFQPEERS DSDVNNDRST SSVDSDILSS SHSSDTLCNA DGTPIPLANG 

       970        980        990       1000       1010       1020 
LDSHSITSSR RSKANDGKKE TWDTAEEDSG TDSEYDESGK SRGEAQYMYF KAEPHAGEGC 

      1030       1040       1050       1060       1070       1080 
LAEGSKCLLV NVDKRITLAA FKQQLESFVG VPSSQFKVFR VYASNQEFES VRLNETLSSF 

      1090       1100       1110       1120       1130       1140 
SDDNKITIRL GRALKKGEYR VKIFQLLVNE PEPCKFVLDA VFSKGMTVRQ SKEELLPLLR 

      1150       1160       1170       1180       1190       1200 
EQCGLDLSID RFRLRKKTWK NPGTVFLDSH VYENESISSC WEVLLEALDE TEKMKSMSQL 

      1210       1220       1230       1240       1250       1260 
SLFTKRWRPS ELKLDPFKEV VLESNSVEEL RDKICEISAI PLENLEFAKG RGTFPCDISV 

      1270       1280       1290       1300       1310       1320 
LEIHQDLDWN PKVSTLNAWP LYISDDGAVI FYRDKTEEVM ELTDEQRNEL VKKESSRLQK 

      1330       1340       1350 
TGHRVTYSPR KEKALKIYLD GPTNKDSAQD 

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC086278 mRNA. Translation: AAH86278.1.
RefSeqNP_001088634.1. NM_001095165.1.
UniGeneXl.49309.

3D structure databases

ProteinModelPortalQ5U252.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID495686.
KEGGxla:495686.

Organism-specific databases

CTD55031.
XenbaseXB-GENE-5760104. usp47.

Phylogenomic databases

HOVERGENHBG058854.
KOK11857.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF14560. Ubiquitin_2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP47_XENLA
AccessionPrimary (citable) accession number: Q5U252
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries