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Q5U252

- UBP47_XENLA

UniProt

Q5U252 - UBP47_XENLA

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Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

usp47

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821NucleophilePROSITE-ProRule annotation
Active sitei487 – 4871Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. base-excision repair Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. monoubiquitinated protein deubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene namesi
Name:usp47
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5760104. usp47.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13501350Ubiquitin carboxyl-terminal hydrolase 47PRO_0000408358Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5U252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 548376USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP47 subfamily.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

HOVERGENiHBG058854.
KOiK11857.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF14560. Ubiquitin_2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U252-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPGEESQLV PKEIENAADE PRVLCIVQDT TNCKSVNERI TLNLPASTSV
60 70 80 90 100
KQLYEDVSNK AGYVSSTFSL MWGNGASNTD MAALDPTPDR TLQEAGFEAG
110 120 130 140 150
KKNFLHLTDK DGEQPQLTSD ESGTADSSGL DDSSQEKFIG PLPREESVAG
160 170 180 190 200
TSNYVSQNYS YSSLLSKSDT GYVGLVNQAM TCYLNSLLQT LFMTPEFRNA
210 220 230 240 250
LYKWEFEESE EDPVSSIPYQ LQRLFVLLQT SKKRAIETTD VTRSFGWDSS
260 270 280 290 300
EAWQQHDVQE LCRVMFDALE QKWKQTEQAD LINQLYQGKL KDYVKCLECG
310 320 330 340 350
YESWRIDTFL DIPLVIRPYG SNTAFGSMEE ALHAFIQPET LDGPNQYFCE
360 370 380 390 400
RCKRKCDARK GLKFLHFPYL LTLQLKRFDF DYTSMHRIKL NDRMTFPDEL
410 420 430 440 450
DMSPFIDMED EKSPQTDSCT DSGAENEGSC HSDQMSNDFS TDDAVDEGIC
460 470 480 490 500
LETNSNIEKL NKSVAEKNSL YELFSVMVHS GSAAGGHYYA CIKSFADGQW
510 520 530 540 550
YSFNDQHVSR ITQEDIKKTY GGATGNRGYY SSAFASSTNA YMLMYRLKNP
560 570 580 590 600
ARNAQFLEAS EFPEHIKLLV QKEQEQEEQE KRQREIERNT CKLKLFCMHP
610 620 630 640 650
VKQIMMESKL EVHKDKTMKE AVEIANKLMD LEGVIPLDCC RLVKYDEFHD
660 670 680 690 700
YLERSYEDEE DRTMGYLLGG VKSSYMFDLL LETKRPDQVF QSYKPGEVMV
710 720 730 740 750
KVYVVDLKTE TVASPVSVRA YLSQTIIEFK QLISKSVDLP PDSMRVILER
760 770 780 790 800
CYNDLRLLNV ANKTLKAEGF FRSNKVFVES SDSLDHQLVF TDSHLWKLLD
810 820 830 840 850
RHANTIKLYV SLPEHPRPTA RSVGPKGGGD MNPQEDYCSR AKSVDAILEE
860 870 880 890 900
STEKLKSLSL QQHQDGGNGD SSKSTEGSDF ENIDSPLNEV DSSGSADNRE
910 920 930 940 950
LENRILPADP ENNFQPEERS DSDVNNDRST SSVDSDILSS SHSSDTLCNA
960 970 980 990 1000
DGTPIPLANG LDSHSITSSR RSKANDGKKE TWDTAEEDSG TDSEYDESGK
1010 1020 1030 1040 1050
SRGEAQYMYF KAEPHAGEGC LAEGSKCLLV NVDKRITLAA FKQQLESFVG
1060 1070 1080 1090 1100
VPSSQFKVFR VYASNQEFES VRLNETLSSF SDDNKITIRL GRALKKGEYR
1110 1120 1130 1140 1150
VKIFQLLVNE PEPCKFVLDA VFSKGMTVRQ SKEELLPLLR EQCGLDLSID
1160 1170 1180 1190 1200
RFRLRKKTWK NPGTVFLDSH VYENESISSC WEVLLEALDE TEKMKSMSQL
1210 1220 1230 1240 1250
SLFTKRWRPS ELKLDPFKEV VLESNSVEEL RDKICEISAI PLENLEFAKG
1260 1270 1280 1290 1300
RGTFPCDISV LEIHQDLDWN PKVSTLNAWP LYISDDGAVI FYRDKTEEVM
1310 1320 1330 1340 1350
ELTDEQRNEL VKKESSRLQK TGHRVTYSPR KEKALKIYLD GPTNKDSAQD
Length:1,350
Mass (Da):153,261
Last modified:December 7, 2004 - v1
Checksum:iEEABB140B02AF3AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086278 mRNA. Translation: AAH86278.1.
RefSeqiNP_001088634.1. NM_001095165.1.
UniGeneiXl.49309.

Genome annotation databases

GeneIDi495686.
KEGGixla:495686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086278 mRNA. Translation: AAH86278.1 .
RefSeqi NP_001088634.1. NM_001095165.1.
UniGenei Xl.49309.

3D structure databases

ProteinModelPortali Q5U252.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495686.
KEGGi xla:495686.

Organism-specific databases

CTDi 55031.
Xenbasei XB-GENE-5760104. usp47.

Phylogenomic databases

HOVERGENi HBG058854.
KOi K11857.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF14560. Ubiquitin_2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiUBP47_XENLA
AccessioniPrimary (citable) accession number: Q5U252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3