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Q5U252

- UBP47_XENLA

UniProt

Q5U252 - UBP47_XENLA

Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

usp47

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER).By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei182 – 1821NucleophilePROSITE-ProRule annotation
    Active sitei487 – 4871Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. base-excision repair Source: UniProtKB
    2. cellular response to DNA damage stimulus Source: UniProtKB
    3. monoubiquitinated protein deubiquitination Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    DNA damage, DNA repair, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.055.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 47
    Ubiquitin thioesterase 47
    Ubiquitin-specific-processing protease 47
    Gene namesi
    Name:usp47
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5760104. usp47.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13501350Ubiquitin carboxyl-terminal hydrolase 47PRO_0000408358Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 548376USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP47 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    HOVERGENiHBG058854.
    KOiK11857.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF14560. Ubiquitin_2. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U252-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPGEESQLV PKEIENAADE PRVLCIVQDT TNCKSVNERI TLNLPASTSV     50
    KQLYEDVSNK AGYVSSTFSL MWGNGASNTD MAALDPTPDR TLQEAGFEAG 100
    KKNFLHLTDK DGEQPQLTSD ESGTADSSGL DDSSQEKFIG PLPREESVAG 150
    TSNYVSQNYS YSSLLSKSDT GYVGLVNQAM TCYLNSLLQT LFMTPEFRNA 200
    LYKWEFEESE EDPVSSIPYQ LQRLFVLLQT SKKRAIETTD VTRSFGWDSS 250
    EAWQQHDVQE LCRVMFDALE QKWKQTEQAD LINQLYQGKL KDYVKCLECG 300
    YESWRIDTFL DIPLVIRPYG SNTAFGSMEE ALHAFIQPET LDGPNQYFCE 350
    RCKRKCDARK GLKFLHFPYL LTLQLKRFDF DYTSMHRIKL NDRMTFPDEL 400
    DMSPFIDMED EKSPQTDSCT DSGAENEGSC HSDQMSNDFS TDDAVDEGIC 450
    LETNSNIEKL NKSVAEKNSL YELFSVMVHS GSAAGGHYYA CIKSFADGQW 500
    YSFNDQHVSR ITQEDIKKTY GGATGNRGYY SSAFASSTNA YMLMYRLKNP 550
    ARNAQFLEAS EFPEHIKLLV QKEQEQEEQE KRQREIERNT CKLKLFCMHP 600
    VKQIMMESKL EVHKDKTMKE AVEIANKLMD LEGVIPLDCC RLVKYDEFHD 650
    YLERSYEDEE DRTMGYLLGG VKSSYMFDLL LETKRPDQVF QSYKPGEVMV 700
    KVYVVDLKTE TVASPVSVRA YLSQTIIEFK QLISKSVDLP PDSMRVILER 750
    CYNDLRLLNV ANKTLKAEGF FRSNKVFVES SDSLDHQLVF TDSHLWKLLD 800
    RHANTIKLYV SLPEHPRPTA RSVGPKGGGD MNPQEDYCSR AKSVDAILEE 850
    STEKLKSLSL QQHQDGGNGD SSKSTEGSDF ENIDSPLNEV DSSGSADNRE 900
    LENRILPADP ENNFQPEERS DSDVNNDRST SSVDSDILSS SHSSDTLCNA 950
    DGTPIPLANG LDSHSITSSR RSKANDGKKE TWDTAEEDSG TDSEYDESGK 1000
    SRGEAQYMYF KAEPHAGEGC LAEGSKCLLV NVDKRITLAA FKQQLESFVG 1050
    VPSSQFKVFR VYASNQEFES VRLNETLSSF SDDNKITIRL GRALKKGEYR 1100
    VKIFQLLVNE PEPCKFVLDA VFSKGMTVRQ SKEELLPLLR EQCGLDLSID 1150
    RFRLRKKTWK NPGTVFLDSH VYENESISSC WEVLLEALDE TEKMKSMSQL 1200
    SLFTKRWRPS ELKLDPFKEV VLESNSVEEL RDKICEISAI PLENLEFAKG 1250
    RGTFPCDISV LEIHQDLDWN PKVSTLNAWP LYISDDGAVI FYRDKTEEVM 1300
    ELTDEQRNEL VKKESSRLQK TGHRVTYSPR KEKALKIYLD GPTNKDSAQD 1350
    Length:1,350
    Mass (Da):153,261
    Last modified:December 7, 2004 - v1
    Checksum:iEEABB140B02AF3AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086278 mRNA. Translation: AAH86278.1.
    RefSeqiNP_001088634.1. NM_001095165.1.
    UniGeneiXl.49309.

    Genome annotation databases

    GeneIDi495686.
    KEGGixla:495686.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086278 mRNA. Translation: AAH86278.1 .
    RefSeqi NP_001088634.1. NM_001095165.1.
    UniGenei Xl.49309.

    3D structure databases

    ProteinModelPortali Q5U252.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.055.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 495686.
    KEGGi xla:495686.

    Organism-specific databases

    CTDi 55031.
    Xenbasei XB-GENE-5760104. usp47.

    Phylogenomic databases

    HOVERGENi HBG058854.
    KOi K11857.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF14560. Ubiquitin_2. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiUBP47_XENLA
    AccessioniPrimary (citable) accession number: Q5U252
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3