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Protein

THAP domain-containing protein 1

Gene

Thap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri5 – 5753THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 1
Gene namesi
Name:Thap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1307589. Thap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210THAP domain-containing protein 1PRO_0000068641Add
BLAST

Proteomic databases

PaxDbiQ5U208.
PRIDEiQ5U208.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014213.

Interactioni

Subunit structurei

Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019026.

Structurei

3D structure databases

ProteinModelPortaliQ5U208.
SMRiQ5U208. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili140 – 18748Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1344HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Belongs to the THAP1 family.Curated
Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri5 – 5753THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGDI. Eukaryota.
ENOG4111FGC. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG057457.
InParanoidiQ5U208.
OMAiSCDHNYT.
OrthoDBiEOG091G034R.
PhylomeDBiQ5U208.
TreeFamiTF330127.

Family and domain databases

InterProiIPR026516. THAP1.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF85. PTHR23080:SF85. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKQWEAAV RRKNFKPTKY
60 70 80 90 100
SSICSEHFTP DCFKRECNNK LLKENAVPTI FLYIEPHEKK EELEPQEQLP
110 120 130 140 150
SPSPPTSQVD AAVGLLMPPL QTPDNLSVFC DHNYTVEDTM HQRKRILHLE
160 170 180 190 200
QQVEKLRKKL KTAQQRCRRQ ERQLEKLKEV VHFQREKDDA SERGYVILPN
210
DYFEIVEVPA
Length:210
Mass (Da):24,688
Last modified:December 7, 2004 - v1
Checksum:iA123F6338571A62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086347 mRNA. Translation: AAH86347.1.
RefSeqiNP_001008341.1. NM_001008340.1.
UniGeneiRn.52291.

Genome annotation databases

EnsembliENSRNOT00000080051; ENSRNOP00000071777; ENSRNOG00000056956.
GeneIDi306547.
KEGGirno:306547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086347 mRNA. Translation: AAH86347.1.
RefSeqiNP_001008341.1. NM_001008340.1.
UniGeneiRn.52291.

3D structure databases

ProteinModelPortaliQ5U208.
SMRiQ5U208. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019026.

Proteomic databases

PaxDbiQ5U208.
PRIDEiQ5U208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080051; ENSRNOP00000071777; ENSRNOG00000056956.
GeneIDi306547.
KEGGirno:306547.

Organism-specific databases

CTDi55145.
RGDi1307589. Thap1.

Phylogenomic databases

eggNOGiENOG410IGDI. Eukaryota.
ENOG4111FGC. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG057457.
InParanoidiQ5U208.
OMAiSCDHNYT.
OrthoDBiEOG091G034R.
PhylomeDBiQ5U208.
TreeFamiTF330127.

Miscellaneous databases

PROiQ5U208.

Gene expression databases

BgeeiENSRNOG00000014213.

Family and domain databases

InterProiIPR026516. THAP1.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF85. PTHR23080:SF85. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP1_RAT
AccessioniPrimary (citable) accession number: Q5U208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.