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Protein

THAP domain-containing protein 1

Gene

Thap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 57THAP-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 1
Gene namesi
Name:Thap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1307589. Thap1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686411 – 210THAP domain-containing protein 1Add BLAST210

Proteomic databases

PaxDbiQ5U208.
PRIDEiQ5U208.

Expressioni

Gene expression databases

BgeeiENSRNOG00000056956.

Interactioni

Subunit structurei

Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019026.

Structurei

3D structure databases

ProteinModelPortaliQ5U208.
SMRiQ5U208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili140 – 187Sequence analysisAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 134HCFC1-binding motif (HBM)By similarity4

Sequence similaritiesi

Belongs to the THAP1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 57THAP-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGDI. Eukaryota.
ENOG4111FGC. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG057457.
InParanoidiQ5U208.
OMAiHQRKRIQ.
OrthoDBiEOG091G034R.
PhylomeDBiQ5U208.
TreeFamiTF330127.

Family and domain databases

InterProiView protein in InterPro
IPR026516. THAP1.
IPR006612. Znf_C2CH.
PANTHERiPTHR23080:SF90. PTHR23080:SF90. 1 hit.
PfamiView protein in Pfam
PF05485. THAP. 1 hit.
SMARTiView protein in SMART
SM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
PROSITEiView protein in PROSITE
PS50950. ZF_THAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKQWEAAV RRKNFKPTKY
60 70 80 90 100
SSICSEHFTP DCFKRECNNK LLKENAVPTI FLYIEPHEKK EELEPQEQLP
110 120 130 140 150
SPSPPTSQVD AAVGLLMPPL QTPDNLSVFC DHNYTVEDTM HQRKRILHLE
160 170 180 190 200
QQVEKLRKKL KTAQQRCRRQ ERQLEKLKEV VHFQREKDDA SERGYVILPN
210
DYFEIVEVPA
Length:210
Mass (Da):24,688
Last modified:December 7, 2004 - v1
Checksum:iA123F6338571A62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086347 mRNA. Translation: AAH86347.1.
RefSeqiNP_001008341.1. NM_001008340.1.
UniGeneiRn.52291.

Genome annotation databases

EnsembliENSRNOT00000080051; ENSRNOP00000071777; ENSRNOG00000056956.
GeneIDi306547.
KEGGirno:306547.

Similar proteinsi

Entry informationi

Entry nameiTHAP1_RAT
AccessioniPrimary (citable) accession number: Q5U208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 7, 2004
Last modified: August 30, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families