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Protein

Calmodulin-like protein 3

Gene

Calml3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity).By similarity

Miscellaneous

Binds four calcium ions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 3
Gene namesi
Name:Calml3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1305499 Calml3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845221 – 149Calmodulin-like protein 3Add BLAST149

Proteomic databases

PaxDbiQ5U206
PRIDEiQ5U206

PTM databases

iPTMnetiQ5U206
PhosphoSitePlusiQ5U206

Expressioni

Gene expression databases

BgeeiENSRNOG00000031955
GenevisibleiQ5U206 RN

Interactioni

Subunit structurei

Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043121

Structurei

3D structure databases

ProteinModelPortaliQ5U206
SMRiQ5U206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ5U206
KOiK02183
OMAiCITTQEL
OrthoDBiEOG091G0V73
PhylomeDBiQ5U206
TreeFamiTF300912

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q5U206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQLTEEQI AEFKEAFSLF DKDGDGCITT QELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMVNEIDKDG NGTVDFPEFL TMMSRKMKDT DSEEEIREAF RVFDKDGNGF
110 120 130 140
VSAAELRHVM TRLGEKLSDE EVDEMIQAAD TDGDGQVNYE EFVHMLVSK
Length:149
Mass (Da):16,803
Last modified:December 7, 2004 - v1
Checksum:i182598B628F78B56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086350 mRNA Translation: AAH86350.1
RefSeqiNP_001012054.1, NM_001012054.1
XP_006254270.1, XM_006254208.3
UniGeneiRn.105124

Genome annotation databases

EnsembliENSRNOT00000046667; ENSRNOP00000043121; ENSRNOG00000031955
GeneIDi307100
KEGGirno:307100
UCSCiRGD:1305499 rat

Similar proteinsi

Entry informationi

Entry nameiCALL3_RAT
AccessioniPrimary (citable) accession number: Q5U206
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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