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Protein

Ragulator complex protein LAMTOR3

Gene

Lamtor3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1632852. Macroautophagy.
R-RNO-165159. mTOR signalling.
R-RNO-166208. mTORC1-mediated signalling.
R-RNO-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-5674135. MAP2K and MAPK activation.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR3
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
Mitogen-activated protein kinase kinase 1-interacting protein 1
Gene namesi
Name:Lamtor3
Synonyms:Map2k1ip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1307133. Lamtor3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406581 – 124Ragulator complex protein LAMTOR3Add BLAST124

Proteomic databases

PaxDbiQ5U204.
PRIDEiQ5U204.

PTM databases

iPTMnetiQ5U204.
PhosphoSitePlusiQ5U204.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010552.
GenevisibleiQ5U204. RN.

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR2; the interaction is direct. Interacts with MAP2K1/MEK1 and MAPK2 (By similarity). Interacts with MORG1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014027.

Structurei

3D structure databases

ProteinModelPortaliQ5U204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 70Required for interaction with LAMTOR2By similarityAdd BLAST14

Sequence similaritiesi

Belongs to the LAMTOR3 family.Curated

Phylogenomic databases

eggNOGiENOG410IWYZ. Eukaryota.
ENOG4111KCU. LUCA.
GeneTreeiENSGT00390000013159.
HOVERGENiHBG052480.
InParanoidiQ5U204.
KOiK04370.
OMAiDCNTGHI.
OrthoDBiEOG091G0TYL.
PhylomeDBiQ5U204.
TreeFamiTF324889.

Family and domain databases

InterProiIPR015019. LAMTOR3.
[Graphical view]
PANTHERiPTHR13378. PTHR13378. 1 hit.
PfamiPF08923. MAPKK1_Int. 1 hit.
[Graphical view]
SMARTiSM01278. MAPKK1_Int. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDSA PEHALRPGFL
60 70 80 90 100
STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSNANT
110 120
GLIVSLEKEL APLFEELIKV VEVS
Length:124
Mass (Da):13,580
Last modified:December 7, 2004 - v1
Checksum:i3B9C8A1E901506A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086353 mRNA. Translation: AAH86353.1.
RefSeqiNP_001008376.1. NM_001008375.1.
XP_006233445.1. XM_006233383.3.
XP_006233447.1. XM_006233385.3.
UniGeneiRn.1123.

Genome annotation databases

EnsembliENSRNOT00000014027; ENSRNOP00000014027; ENSRNOG00000010552.
GeneIDi362045.
KEGGirno:362045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086353 mRNA. Translation: AAH86353.1.
RefSeqiNP_001008376.1. NM_001008375.1.
XP_006233445.1. XM_006233383.3.
XP_006233447.1. XM_006233385.3.
UniGeneiRn.1123.

3D structure databases

ProteinModelPortaliQ5U204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014027.

PTM databases

iPTMnetiQ5U204.
PhosphoSitePlusiQ5U204.

Proteomic databases

PaxDbiQ5U204.
PRIDEiQ5U204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014027; ENSRNOP00000014027; ENSRNOG00000010552.
GeneIDi362045.
KEGGirno:362045.

Organism-specific databases

CTDi8649.
RGDi1307133. Lamtor3.

Phylogenomic databases

eggNOGiENOG410IWYZ. Eukaryota.
ENOG4111KCU. LUCA.
GeneTreeiENSGT00390000013159.
HOVERGENiHBG052480.
InParanoidiQ5U204.
KOiK04370.
OMAiDCNTGHI.
OrthoDBiEOG091G0TYL.
PhylomeDBiQ5U204.
TreeFamiTF324889.

Enzyme and pathway databases

ReactomeiR-RNO-1632852. Macroautophagy.
R-RNO-165159. mTOR signalling.
R-RNO-166208. mTORC1-mediated signalling.
R-RNO-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-5674135. MAP2K and MAPK activation.
R-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ5U204.

Gene expression databases

BgeeiENSRNOG00000010552.
GenevisibleiQ5U204. RN.

Family and domain databases

InterProiIPR015019. LAMTOR3.
[Graphical view]
PANTHERiPTHR13378. PTHR13378. 1 hit.
PfamiPF08923. MAPKK1_Int. 1 hit.
[Graphical view]
SMARTiSM01278. MAPKK1_Int. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR3_RAT
AccessioniPrimary (citable) accession number: Q5U204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.