Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ragulator complex protein LAMTOR3

Gene

Lamtor3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1632852 Macroautophagy
R-RNO-165159 mTOR signalling
R-RNO-166208 mTORC1-mediated signalling
R-RNO-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-RNO-5628897 TP53 Regulates Metabolic Genes
R-RNO-5674135 MAP2K and MAPK activation
R-RNO-6798695 Neutrophil degranulation
R-RNO-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR3
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
Mitogen-activated protein kinase kinase 1-interacting protein 1
Gene namesi
Name:Lamtor3
Synonyms:Map2k1ip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1307133 Lamtor3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406581 – 124Ragulator complex protein LAMTOR3Add BLAST124

Proteomic databases

PaxDbiQ5U204
PRIDEiQ5U204

PTM databases

iPTMnetiQ5U204
PhosphoSitePlusiQ5U204

Expressioni

Gene expression databases

BgeeiENSRNOG00000010552
GenevisibleiQ5U204 RN

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR2; the interaction is direct. Interacts with MAP2K1/MEK1 and MAPK2 (By similarity). Interacts with MORG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014027

Structurei

3D structure databases

ProteinModelPortaliQ5U204
SMRiQ5U204
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 70Required for interaction with LAMTOR2By similarityAdd BLAST14

Sequence similaritiesi

Belongs to the LAMTOR3 family.Curated

Phylogenomic databases

eggNOGiENOG410IWYZ Eukaryota
ENOG4111KCU LUCA
GeneTreeiENSGT00390000013159
HOVERGENiHBG052480
InParanoidiQ5U204
KOiK04370
OMAiYQVIQMN
OrthoDBiEOG091G0TYL
PhylomeDBiQ5U204
TreeFamiTF324889

Family and domain databases

InterProiView protein in InterPro
IPR015019 LAMTOR3
PANTHERiPTHR13378 PTHR13378, 1 hit
PfamiView protein in Pfam
PF08923 MAPKK1_Int, 1 hit
SMARTiView protein in SMART
SM01278 MAPKK1_Int, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDSA PEHALRPGFL
60 70 80 90 100
STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSNANT
110 120
GLIVSLEKEL APLFEELIKV VEVS
Length:124
Mass (Da):13,580
Last modified:December 7, 2004 - v1
Checksum:i3B9C8A1E901506A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086353 mRNA Translation: AAH86353.1
RefSeqiNP_001008376.1, NM_001008375.1
XP_006233445.1, XM_006233383.3
XP_006233447.1, XM_006233385.3
UniGeneiRn.1123

Genome annotation databases

EnsembliENSRNOT00000014027; ENSRNOP00000014027; ENSRNOG00000010552
GeneIDi362045
KEGGirno:362045

Similar proteinsi

Entry informationi

Entry nameiLTOR3_RAT
AccessioniPrimary (citable) accession number: Q5U204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome