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Protein

1,5-anhydro-D-fructose reductase

Gene

Akr1e2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol.By similarity

Catalytic activityi

1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH.By similarity

Enzyme regulationi

Inhibited by p-chloromercuribenzoic acid and alkyliodines.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35NADPBy similarity1
Active sitei40Proton donorBy similarity1
Sitei69Lowers pKa of active site TyrBy similarity1
Binding sitei102SubstrateBy similarity1
Binding sitei175NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 258NADPBy similarityAdd BLAST13

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
1,5-anhydro-D-fructose reductase (EC:1.1.1.263By similarity)
Short name:
AF reductase
Alternative name(s):
Aldo-keto reductase family 1 member C-like protein 2
Aldo-keto reductase family 1 member E2
Gene namesi
Name:Akr1e2
Synonyms:Akr1cl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1309599 Akr1e2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003768961 – 3011,5-anhydro-D-fructose reductaseAdd BLAST301

Proteomic databases

PaxDbiQ5U1Y4
PRIDEiQ5U1Y4

Expressioni

Gene expression databases

BgeeiENSRNOG00000017165
GenevisibleiQ5U1Y4 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023133

Structurei

3D structure databases

ProteinModelPortaliQ5U1Y4
SMRiQ5U1Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOGENOMiHOG000250272
InParanoidiQ5U1Y4
KOiK13981
OMAiAYFYHNE
OrthoDBiEOG091G0D69
PhylomeDBiQ5U1Y4
TreeFamiTF106492

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U1Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQIPTVGLG TWKASPGEVT DAVKVAINLG YRHFDCAYLY HNESEVGMGI
60 70 80 90 100
KEKIKEGVVK RDELFIVSKL WCTYHKQSLV KTACINTLEA LNLDYLDLYL
110 120 130 140 150
IHWPMGFKPG DKDIPLDRSG KVIPSHTSFL DTWEAMEDLV IEGLVKNIGV
160 170 180 190 200
SNFNHEQLDR LLNKPGLRIK PITNQIECHP YLNQKSLIDF CHGRNVSVTA
210 220 230 240 250
YRPLGGSRDG VHLMDDIVIR KIAKKHGKSP AQILIRFQIQ RNLIVIPKSV
260 270 280 290 300
NPSRIRENIQ VFDFELTEKD MEELLSLDKN LRLATFPSTE NHKDYPFHIE

Y
Length:301
Mass (Da):34,500
Last modified:December 7, 2004 - v1
Checksum:iF6786B806D5AE64B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086397 mRNA Translation: AAH86397.1
RefSeqiNP_001008343.1, NM_001008342.1
UniGeneiRn.108718

Genome annotation databases

EnsembliENSRNOT00000023133; ENSRNOP00000023133; ENSRNOG00000017165
GeneIDi307091
KEGGirno:307091
UCSCiRGD:1309599 rat

Similar proteinsi

Entry informationi

Entry nameiAKCL2_RAT
AccessioniPrimary (citable) accession number: Q5U1Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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