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Protein

Ras-related protein Rab-34

Gene

Rab34

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668GTPBy similarity
Nucleotide bindingi107 – 1115GTPBy similarity
Nucleotide bindingi166 – 1694GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34
Gene namesi
Name:Rab34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305058. Rab34.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Ras-related protein Rab-34PRO_0000315238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei241 – 2411PhosphoserineBy similarity
Lipidationi257 – 2571S-geranylgeranyl cysteineSequence Analysis
Lipidationi258 – 2581S-geranylgeranyl cysteineSequence Analysis

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ5U1Y1.
PRIDEiQ5U1Y1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5U1Y1. baseline and differential.
GenevisibleiQ5U1Y1. RN.

Interactioni

Subunit structurei

Interacts with RILP.By similarity

Protein-protein interaction databases

IntActiQ5U1Y1. 1 interaction.
STRINGi10116.ENSRNOP00000036566.

Structurei

3D structure databases

ProteinModelPortaliQ5U1Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 899Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233970.
HOVERGENiHBG106693.
InParanoidiQ5U1Y1.
KOiK07921.
OrthoDBiEOG7MH10M.
PhylomeDBiQ5U1Y1.
TreeFamiTF326626.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U1Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF
60 70 80 90 100
KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP
110 120 130 140 150
FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHSKQWLADA
160 170 180 190 200
LKENDPSNVL LFLVGSKKDL STPAQYSLME KDALKVAQEI KAEYWSVSSL
210 220 230 240 250
TGENVREFFF RVAALTFEAN VLAELEKSGS RHIGDVVRIN SDDKNLYLTA

SKKKATCCP
Length:259
Mass (Da):29,103
Last modified:December 7, 2004 - v1
Checksum:i17593A92727B8389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086400 mRNA. Translation: AAH86400.1.
RefSeqiNP_001012140.1. NM_001012140.1.
UniGeneiRn.98493.

Genome annotation databases

GeneIDi360571.
KEGGirno:360571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086400 mRNA. Translation: AAH86400.1.
RefSeqiNP_001012140.1. NM_001012140.1.
UniGeneiRn.98493.

3D structure databases

ProteinModelPortaliQ5U1Y1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5U1Y1. 1 interaction.
STRINGi10116.ENSRNOP00000036566.

Proteomic databases

PaxDbiQ5U1Y1.
PRIDEiQ5U1Y1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360571.
KEGGirno:360571.

Organism-specific databases

CTDi83871.
RGDi1305058. Rab34.

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233970.
HOVERGENiHBG106693.
InParanoidiQ5U1Y1.
KOiK07921.
OrthoDBiEOG7MH10M.
PhylomeDBiQ5U1Y1.
TreeFamiTF326626.

Miscellaneous databases

NextBioi673257.
PROiQ5U1Y1.

Gene expression databases

ExpressionAtlasiQ5U1Y1. baseline and differential.
GenevisibleiQ5U1Y1. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiRAB34_RAT
AccessioniPrimary (citable) accession number: Q5U1Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: June 24, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.