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Q5U1Y1

- RAB34_RAT

UniProt

Q5U1Y1 - RAB34_RAT

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Protein

Ras-related protein Rab-34

Gene

Rab34

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668GTPBy similarity
Nucleotide bindingi107 – 1115GTPBy similarity
Nucleotide bindingi166 – 1694GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: Ensembl
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. phagosome-lysosome fusion Source: UniProtKB
  2. phagosome maturation Source: UniProtKB
  3. protein transport Source: UniProtKB-KW
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34
Gene namesi
Name:Rab34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1305058. Rab34.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

GO - Cellular componenti

  1. early endosome Source: Ensembl
  2. Golgi apparatus Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
  4. phagocytic vesicle Source: UniProtKB
  5. ruffle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Ras-related protein Rab-34PRO_0000315238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei241 – 2411PhosphoserineBy similarity
Lipidationi257 – 2571S-geranylgeranyl cysteineSequence Analysis
Lipidationi258 – 2581S-geranylgeranyl cysteineSequence Analysis

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ5U1Y1.
PRIDEiQ5U1Y1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5U1Y1. baseline.
GenevestigatoriQ5U1Y1.

Interactioni

Subunit structurei

Interacts with RILP.By similarity

Protein-protein interaction databases

IntActiQ5U1Y1. 1 interaction.
STRINGi10116.ENSRNOP00000036566.

Structurei

3D structure databases

ProteinModelPortaliQ5U1Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 899Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233970.
HOVERGENiHBG106693.
InParanoidiQ5U1Y1.
KOiK07921.
OrthoDBiEOG7MH10M.
PhylomeDBiQ5U1Y1.
TreeFamiTF326626.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U1Y1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF
60 70 80 90 100
KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP
110 120 130 140 150
FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHSKQWLADA
160 170 180 190 200
LKENDPSNVL LFLVGSKKDL STPAQYSLME KDALKVAQEI KAEYWSVSSL
210 220 230 240 250
TGENVREFFF RVAALTFEAN VLAELEKSGS RHIGDVVRIN SDDKNLYLTA

SKKKATCCP
Length:259
Mass (Da):29,103
Last modified:December 7, 2004 - v1
Checksum:i17593A92727B8389
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC086400 mRNA. Translation: AAH86400.1.
RefSeqiNP_001012140.1. NM_001012140.1.
UniGeneiRn.98493.

Genome annotation databases

GeneIDi360571.
KEGGirno:360571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC086400 mRNA. Translation: AAH86400.1 .
RefSeqi NP_001012140.1. NM_001012140.1.
UniGenei Rn.98493.

3D structure databases

ProteinModelPortali Q5U1Y1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5U1Y1. 1 interaction.
STRINGi 10116.ENSRNOP00000036566.

Proteomic databases

PaxDbi Q5U1Y1.
PRIDEi Q5U1Y1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 360571.
KEGGi rno:360571.

Organism-specific databases

CTDi 83871.
RGDi 1305058. Rab34.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233970.
HOVERGENi HBG106693.
InParanoidi Q5U1Y1.
KOi K07921.
OrthoDBi EOG7MH10M.
PhylomeDBi Q5U1Y1.
TreeFami TF326626.

Miscellaneous databases

NextBioi 673257.
PROi Q5U1Y1.

Gene expression databases

ExpressionAtlasi Q5U1Y1. baseline.
Genevestigatori Q5U1Y1.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiRAB34_RAT
AccessioniPrimary (citable) accession number: Q5U1Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3