Q5U1Y1 (RAB34_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-34

Gene names

Name:

Rab34

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region By similarity. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes By similarity.
Subunit structure	Interacts with RILP By similarity.
Subcellular location	Cytoplasm By similarity. Golgi apparatus By similarity. Cytoplasmic vesicle › phagosome By similarity. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoplasmic vesicle Golgi apparatus Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phagosome-lysosome fusion Inferred from sequence or structural similarity. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell early endosome Inferred from electronic annotation. Source: Compara phagocytic vesicle Inferred from sequence or structural similarity. Source: UniProtKB phagocytic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell ruffle Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Ras-related protein Rab-34		PRO_0000315238
Regions
	Nucleotide binding	59 – 66	8	GTP By similarity
	Nucleotide binding	107 – 111	5	GTP By similarity
	Nucleotide binding	166 – 169	4	GTP By similarity
	Motif	81 – 89	9	Effector region By similarity
Amino acid modifications
	Modified residue	241	1	Phosphoserine By similarity
	Lipidation	257	1	S-geranylgeranyl cysteine Potential
	Lipidation	258	1	S-geranylgeranyl cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5U1Y1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 17593A92727B8389	FASTA	259	29,103
	10 20 30 40 50 60 MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD 70 80 90 100 110 120 LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP FSLQLWDTAG QERFKCIAST 130 140 150 160 170 180 YYRGAQAIII VFNLNDVASL EHSKQWLADA LKENDPSNVL LFLVGSKKDL STPAQYSLME 190 200 210 220 230 240 KDALKVAQEI KAEYWSVSSL TGENVREFFF RVAALTFEAN VLAELEKSGS RHIGDVVRIN 250 SDDKNLYLTA SKKKATCCP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC086400 mRNA. Translation: AAH86400.1.
IPI	IPI00372642.
RefSeq	NP_001012140.1. NM_001012140.1.
UniGene	Rn.98493.
3D structure databases
HSSP	HSSP built from PDB template 2FV8 based on UniProtKB P62745.
ProteinModelPortal	Q5U1Y1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5U1Y1. 1 interaction.
STRING	10116.ENSRNOP00000036566.
Proteomic databases
PaxDb	Q5U1Y1.
PRIDE	Q5U1Y1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	360571.
KEGG	rno:360571.
Organism-specific databases
CTD	83871.
RGD	1305058. Rab34.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233970.
HOVERGEN	HBG106693.
InParanoid	Q5U1Y1.
KO	K07921.
OMA	ACQEQRT.
OrthoDB	EOG41NTMP.
Gene expression databases
Genevestigator	Q5U1Y1.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	673257.

Entry information

Entry name

RAB34_RAT

Accession

Primary (citable) accession number: Q5U1Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program