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Protein

Ras-related protein Rab-34

Gene

Rab34

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 66GTPBy similarity8
Nucleotide bindingi107 – 111GTPBy similarity5
Nucleotide bindingi166 – 169GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose stimulus Source: ParkinsonsUK-UCL
  • phagosome-lysosome fusion Source: UniProtKB
  • phagosome maturation Source: UniProtKB
  • positive regulation of protein secretion Source: ParkinsonsUK-UCL
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34
Gene namesi
Name:Rab34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305058. Rab34.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152381 – 259Ras-related protein Rab-34Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei241PhosphoserineBy similarity1
Lipidationi257S-geranylgeranyl cysteineSequence analysis1
Lipidationi258S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ5U1Y1.
PRIDEiQ5U1Y1.

PTM databases

iPTMnetiQ5U1Y1.
PhosphoSitePlusiQ5U1Y1.

Interactioni

Subunit structurei

Interacts with RILP.By similarity

Protein-protein interaction databases

IntActiQ5U1Y1. 1 interactor.
STRINGi10116.ENSRNOP00000036566.

Structurei

3D structure databases

ProteinModelPortaliQ5U1Y1.
SMRiQ5U1Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
HOGENOMiHOG000233970.
HOVERGENiHBG106693.
InParanoidiQ5U1Y1.
KOiK07921.
PhylomeDBiQ5U1Y1.
TreeFamiTF326626.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U1Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF
60 70 80 90 100
KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP
110 120 130 140 150
FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHSKQWLADA
160 170 180 190 200
LKENDPSNVL LFLVGSKKDL STPAQYSLME KDALKVAQEI KAEYWSVSSL
210 220 230 240 250
TGENVREFFF RVAALTFEAN VLAELEKSGS RHIGDVVRIN SDDKNLYLTA

SKKKATCCP
Length:259
Mass (Da):29,103
Last modified:December 7, 2004 - v1
Checksum:i17593A92727B8389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086400 mRNA. Translation: AAH86400.1.
RefSeqiNP_001012140.1. NM_001012140.1.
UniGeneiRn.98493.

Genome annotation databases

GeneIDi360571.
KEGGirno:360571.

Similar proteinsi

Entry informationi

Entry nameiRAB34_RAT
AccessioniPrimary (citable) accession number: Q5U1Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families