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Q5U1Y1

- RAB34_RAT

UniProt

Q5U1Y1 - RAB34_RAT

Protein

Ras-related protein Rab-34

Gene

Rab34

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region By similarity. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi59 – 668GTPBy similarity
    Nucleotide bindingi107 – 1115GTPBy similarity
    Nucleotide bindingi166 – 1694GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: Ensembl
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. phagosome-lysosome fusion Source: UniProtKB
    2. phagosome maturation Source: UniProtKB
    3. protein transport Source: UniProtKB-KW
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-34
    Gene namesi
    Name:Rab34
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1305058. Rab34.

    Subcellular locationi

    Cytoplasm By similarity. Golgi apparatus By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

    GO - Cellular componenti

    1. early endosome Source: Ensembl
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. phagocytic vesicle Source: UniProtKB
    4. phagocytic vesicle membrane Source: UniProtKB-SubCell
    5. ruffle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Ras-related protein Rab-34PRO_0000315238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei241 – 2411PhosphoserineBy similarity
    Lipidationi257 – 2571S-geranylgeranyl cysteineSequence Analysis
    Lipidationi258 – 2581S-geranylgeranyl cysteineSequence Analysis

    Keywords - PTMi

    Acetylation, Lipoprotein, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiQ5U1Y1.
    PRIDEiQ5U1Y1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U1Y1.

    Interactioni

    Subunit structurei

    Interacts with RILP.By similarity

    Protein-protein interaction databases

    IntActiQ5U1Y1. 1 interaction.
    STRINGi10116.ENSRNOP00000036566.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U1Y1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi81 – 899Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233970.
    HOVERGENiHBG106693.
    InParanoidiQ5U1Y1.
    KOiK07921.
    OrthoDBiEOG7MH10M.
    PhylomeDBiQ5U1Y1.
    TreeFamiTF326626.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U1Y1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF    50
    KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP 100
    FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHSKQWLADA 150
    LKENDPSNVL LFLVGSKKDL STPAQYSLME KDALKVAQEI KAEYWSVSSL 200
    TGENVREFFF RVAALTFEAN VLAELEKSGS RHIGDVVRIN SDDKNLYLTA 250
    SKKKATCCP 259
    Length:259
    Mass (Da):29,103
    Last modified:December 7, 2004 - v1
    Checksum:i17593A92727B8389
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086400 mRNA. Translation: AAH86400.1.
    RefSeqiNP_001012140.1. NM_001012140.1.
    UniGeneiRn.98493.

    Genome annotation databases

    GeneIDi360571.
    KEGGirno:360571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086400 mRNA. Translation: AAH86400.1 .
    RefSeqi NP_001012140.1. NM_001012140.1.
    UniGenei Rn.98493.

    3D structure databases

    ProteinModelPortali Q5U1Y1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5U1Y1. 1 interaction.
    STRINGi 10116.ENSRNOP00000036566.

    Proteomic databases

    PaxDbi Q5U1Y1.
    PRIDEi Q5U1Y1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 360571.
    KEGGi rno:360571.

    Organism-specific databases

    CTDi 83871.
    RGDi 1305058. Rab34.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233970.
    HOVERGENi HBG106693.
    InParanoidi Q5U1Y1.
    KOi K07921.
    OrthoDBi EOG7MH10M.
    PhylomeDBi Q5U1Y1.
    TreeFami TF326626.

    Miscellaneous databases

    NextBioi 673257.
    PROi Q5U1Y1.

    Gene expression databases

    Genevestigatori Q5U1Y1.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiRAB34_RAT
    AccessioniPrimary (citable) accession number: Q5U1Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3