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Q5U1Y1 (RAB34_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-34
Gene names
Name:Rab34
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region By similarity. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes By similarity.

Subunit structure

Interacts with RILP By similarity.

Subcellular location

Cytoplasm By similarity. Golgi apparatus By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Ras-related protein Rab-34
PRO_0000315238

Regions

Nucleotide binding59 – 668GTP By similarity
Nucleotide binding107 – 1115GTP By similarity
Nucleotide binding166 – 1694GTP By similarity
Motif81 – 899Effector region By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue2411Phosphoserine By similarity
Lipidation2571S-geranylgeranyl cysteine Potential
Lipidation2581S-geranylgeranyl cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q5U1Y1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 17593A92727B8389

FASTA25929,103
        10         20         30         40         50         60 
MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD 

        70         80         90        100        110        120 
LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP FSLQLWDTAG QERFKCIAST 

       130        140        150        160        170        180 
YYRGAQAIII VFNLNDVASL EHSKQWLADA LKENDPSNVL LFLVGSKKDL STPAQYSLME 

       190        200        210        220        230        240 
KDALKVAQEI KAEYWSVSSL TGENVREFFF RVAALTFEAN VLAELEKSGS RHIGDVVRIN 

       250 
SDDKNLYLTA SKKKATCCP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC086400 mRNA. Translation: AAH86400.1.
RefSeqNP_001012140.1. NM_001012140.1.
UniGeneRn.98493.

3D structure databases

ProteinModelPortalQ5U1Y1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ5U1Y1. 1 interaction.
STRING10116.ENSRNOP00000036566.

Proteomic databases

PaxDbQ5U1Y1.
PRIDEQ5U1Y1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID360571.
KEGGrno:360571.

Organism-specific databases

CTD83871.
RGD1305058. Rab34.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233970.
HOVERGENHBG106693.
InParanoidQ5U1Y1.
KOK07921.
OrthoDBEOG7MH10M.
TreeFamTF326626.

Gene expression databases

GenevestigatorQ5U1Y1.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio673257.
PROQ5U1Y1.

Entry information

Entry nameRAB34_RAT
AccessionPrimary (citable) accession number: Q5U1Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families