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Q5U1W4

- LAP4B_RAT

UniProt

Q5U1W4 - LAP4B_RAT

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Protein

Lysosomal-associated transmembrane protein 4B

Gene

Laptm4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4B
Gene namesi
Name:Laptm4b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1311853. Laptm4b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Lysosomal-associated transmembrane protein 4BPRO_0000249724Add
BLAST

Proteomic databases

PaxDbiQ5U1W4.

Expressioni

Gene expression databases

GenevestigatoriQ5U1W4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008969.

Family & Domainsi

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46169.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ5U1W4.
KOiK12387.
OMAiTIILGIW.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ5U1W4.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U1W4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMVAPWTRF YSHSCCLCCH VRTGTILLGI WYLIINAVVL LILLSALADP
60 70 80 90 100
DQYHFSGSEL GGEFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQHAAW
110 120 130 140 150
IIPFFCYQIF DFALNTLVAI TVLVYPNSIQ EYIRQLPPSF PYRDDIMSVN
160 170 180 190 200
PTCLVLVILL FIGIILTFKG YLISCVWSCY RYINGRNSSD VLVYVTSNDT
210 220
TVLLPPYDDA TAVTGTAKEP PPPYVSA
Length:227
Mass (Da):25,404
Last modified:December 7, 2004 - v1
Checksum:i502B649C22D1C421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086442 mRNA. Translation: AAH86442.1.
RefSeqiNP_001013192.1. NM_001013174.1.
UniGeneiRn.8123.

Genome annotation databases

EnsembliENSRNOT00000008969; ENSRNOP00000008969; ENSRNOG00000006766.
GeneIDi315047.
KEGGirno:315047.
UCSCiRGD:1311853. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086442 mRNA. Translation: AAH86442.1 .
RefSeqi NP_001013192.1. NM_001013174.1.
UniGenei Rn.8123.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008969.

Proteomic databases

PaxDbi Q5U1W4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000008969 ; ENSRNOP00000008969 ; ENSRNOG00000006766 .
GeneIDi 315047.
KEGGi rno:315047.
UCSCi RGD:1311853. rat.

Organism-specific databases

CTDi 55353.
RGDi 1311853. Laptm4b.

Phylogenomic databases

eggNOGi NOG46169.
GeneTreei ENSGT00390000013359.
HOGENOMi HOG000007698.
HOVERGENi HBG000908.
InParanoidi Q5U1W4.
KOi K12387.
OMAi TIILGIW.
OrthoDBi EOG7QC7X3.
PhylomeDBi Q5U1W4.
TreeFami TF330843.

Miscellaneous databases

NextBioi 668544.
PROi Q5U1W4.

Gene expression databases

Genevestigatori Q5U1W4.

Family and domain databases

InterProi IPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view ]
PANTHERi PTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
Pfami PF03821. Mtp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiLAP4B_RAT
AccessioniPrimary (citable) accession number: Q5U1W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3