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Q5U1W4

- LAP4B_RAT

UniProt

Q5U1W4 - LAP4B_RAT

Protein

Lysosomal-associated transmembrane protein 4B

Gene

Laptm4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal-associated transmembrane protein 4B
    Gene namesi
    Name:Laptm4b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1311853. Laptm4b.

    Subcellular locationi

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Lysosomal-associated transmembrane protein 4BPRO_0000249724Add
    BLAST

    Proteomic databases

    PaxDbiQ5U1W4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U1W4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008969.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAPTM4/LAPTM5 transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46169.
    GeneTreeiENSGT00390000013359.
    HOGENOMiHOG000007698.
    HOVERGENiHBG000908.
    InParanoidiQ5U1W4.
    KOiK12387.
    OMAiTIILGIW.
    OrthoDBiEOG7QC7X3.
    PhylomeDBiQ5U1W4.
    TreeFamiTF330843.

    Family and domain databases

    InterProiIPR004687. LAPTM4/5.
    IPR018401. Lysosomal-assoc_TM_prot4B.
    [Graphical view]
    PANTHERiPTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF6. PTHR12479:SF6. 1 hit.
    PfamiPF03821. Mtp. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U1W4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMVAPWTRF YSHSCCLCCH VRTGTILLGI WYLIINAVVL LILLSALADP    50
    DQYHFSGSEL GGEFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQHAAW 100
    IIPFFCYQIF DFALNTLVAI TVLVYPNSIQ EYIRQLPPSF PYRDDIMSVN 150
    PTCLVLVILL FIGIILTFKG YLISCVWSCY RYINGRNSSD VLVYVTSNDT 200
    TVLLPPYDDA TAVTGTAKEP PPPYVSA 227
    Length:227
    Mass (Da):25,404
    Last modified:December 7, 2004 - v1
    Checksum:i502B649C22D1C421
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086442 mRNA. Translation: AAH86442.1.
    RefSeqiNP_001013192.1. NM_001013174.1.
    UniGeneiRn.8123.

    Genome annotation databases

    EnsembliENSRNOT00000008969; ENSRNOP00000008969; ENSRNOG00000006766.
    GeneIDi315047.
    KEGGirno:315047.
    UCSCiRGD:1311853. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086442 mRNA. Translation: AAH86442.1 .
    RefSeqi NP_001013192.1. NM_001013174.1.
    UniGenei Rn.8123.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008969.

    Proteomic databases

    PaxDbi Q5U1W4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008969 ; ENSRNOP00000008969 ; ENSRNOG00000006766 .
    GeneIDi 315047.
    KEGGi rno:315047.
    UCSCi RGD:1311853. rat.

    Organism-specific databases

    CTDi 55353.
    RGDi 1311853. Laptm4b.

    Phylogenomic databases

    eggNOGi NOG46169.
    GeneTreei ENSGT00390000013359.
    HOGENOMi HOG000007698.
    HOVERGENi HBG000908.
    InParanoidi Q5U1W4.
    KOi K12387.
    OMAi TIILGIW.
    OrthoDBi EOG7QC7X3.
    PhylomeDBi Q5U1W4.
    TreeFami TF330843.

    Miscellaneous databases

    NextBioi 668544.
    PROi Q5U1W4.

    Gene expression databases

    Genevestigatori Q5U1W4.

    Family and domain databases

    InterProi IPR004687. LAPTM4/5.
    IPR018401. Lysosomal-assoc_TM_prot4B.
    [Graphical view ]
    PANTHERi PTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF6. PTHR12479:SF6. 1 hit.
    Pfami PF03821. Mtp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiLAP4B_RAT
    AccessioniPrimary (citable) accession number: Q5U1W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3