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Protein
Submitted name:

Ras-GTPase-activating protein SH3-domain-binding protein

Gene

G3BP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ras-GTPase-activating protein SH3-domain-binding proteinImported
Submitted name:
Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_aImported
Submitted name:
Uncharacterized protein DKFZp686L1159Imported
Submitted name:
cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNAImported
Gene namesi
Name:G3BPImported
Synonyms:DKFZp686L1159Imported
ORF Names:hCG_39146Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000145907.14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389105.

Expressioni

Gene expression databases

BgeeiENSG00000145907.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 133NTF2InterPro annotationAdd BLAST123
Domaini340 – 415RRMInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0116. Eukaryota.
ENOG410YV57. LUCA.
HOVERGENiHBG007211.
KOiK17265.
OMAiPKDEVGW.
OrthoDBiEOG091G0GAN.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
cd12463. RRM_G3BP1. 1 hit.
InterProiView protein in InterPro
IPR034375. G3BP1.
IPR034374. G3BP1_RRM.
IPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
PANTHERiPTHR10693:SF21. PTHR10693:SF21. 1 hit.
PfamiView protein in Pfam
PF02136. NTF2. 1 hit.
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50177. NTF2_DOMAIN. 1 hit.
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U0Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK
60 70 80 90 100
PADAVYGQKE IHRKVMSQNF TNCHTKIRHV DAHATLNDGV VVQVMGLLSN
110 120 130 140 150
NNQALRRFMQ TFVLAPEGSV ANKFYVHNDI FRYQDEVFGG FVTEPQEESE
160 170 180 190 200
EEVEEPEERQ QTPEVVPDDS GTFYDQAVVS NDMEEHLEEP VAEPEPDPEP
210 220 230 240 250
EPEQEPVSEI QEEKPEPVLE ETAPEDAQKS SSPAPADIAQ TVQEDLRTFS
260 270 280 290 300
WASVTSKNLP PSGAVPVTGI PPHVVKVPAS QPRPESKPES QIPPQRPQRD
310 320 330 340 350
QRVREQRINI PPQRGPRPIR EAGEQGDIEP RRMVRHPDSH QLFIGNLPHE
360 370 380 390 400
VDKSELKDFF QSYGNVVELR INSGGKLPNF GFVVFDDSEP VQKVLSNRPI
410 420 430 440 450
MFRGEVRLNV EEKKTRAARE GDRRDNRLRG PGGPRGGLGG GMRGPPRGGM
460
VQKPGFGVGR GLAPRQ
Length:466
Mass (Da):52,164
Last modified:May 10, 2005 - v1
Checksum:i0F9429D78E0C7F59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019384 mRNA. Translation: AAV38191.1.
AK312572 mRNA. Translation: BAG35467.1.
BX648012 mRNA. Translation: CAI46067.1.
CH471062 Genomic DNA. Translation: EAW61659.1.
CH471062 Genomic DNA. Translation: EAW61660.1.
RefSeqiNP_005745.1. NM_005754.2.
NP_938405.1. NM_198395.1.
XP_006714812.1. XM_006714749.3.
XP_006714813.1. XM_006714750.3.
XP_016864411.1. XM_017008922.1.
XP_016864412.1. XM_017008923.1.
UniGeneiHs.3353.
Hs.587054.

Genome annotation databases

GeneIDi10146.
KEGGihsa:10146.
UCSCiuc003lum.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ5U0Q1_HUMAN
AccessioniPrimary (citable) accession number: Q5U0Q1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.