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Protein
Submitted name:

Sodium channel, voltage-gated, type II, beta

Gene

SCN2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium channel, voltage-gated, type II, betaImported
Submitted name:
cDNA, FLJ94526, Homo sapiens sodium channel, voltage-gated, type II, beta (SCN2B),mRNAImported
Gene namesi
Name:SCN2BImported
ORF Names:hCG_41149Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000149575.5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei158 – 180HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501431013530 – 215Sequence analysisAdd BLAST186

Expressioni

Gene expression databases

BgeeiENSG00000149575
ExpressionAtlasiQ5U0K8 baseline and differential

Structurei

3D structure databases

SMRiQ5U0K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 131Ig-likeInterPro annotationAdd BLAST106

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410II8M Eukaryota
ENOG4111M25 LUCA
HOVERGENiHBG003443
KOiK04846
OMAiHGKIYLQ
OrthoDBiEOG091G0O9E

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000920 Myelin_P0-rel
IPR029873 SCN2B
PANTHERiPTHR13869 PTHR13869, 1 hit
PTHR13869:SF3 PTHR13869:SF3, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PRINTSiPR00213 MYELINP0
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U0K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC
60 70 80 90 100
TFNSCYTVNH KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE
110 120 130 140 150
FSGNPSKYDV SVMLRNVQPE DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE
160 170 180 190 200
PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE
210
EGKTDGEGNP DDGAK
Length:215
Mass (Da):24,326
Last modified:May 10, 2005 - v1
Checksum:i94A30A60A32683F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019487 mRNA Translation: AAV38294.1
AK313891 mRNA Translation: BAG36614.1
CH471065 Genomic DNA Translation: EAW67353.1
RefSeqiNP_004579.1, NM_004588.4
UniGeneiHs.129783

Genome annotation databases

GeneIDi6327
KEGGihsa:6327
UCSCiuc001psf.3 human

Similar proteinsi

Entry informationi

Entry nameiQ5U0K8_HUMAN
AccessioniPrimary (citable) accession number: Q5U0K8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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