Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Sodium channel, voltage-gated, type II, beta

Gene

SCN2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium channel, voltage-gated, type II, betaImported
Submitted name:
cDNA, FLJ94526, Homo sapiens sodium channel, voltage-gated, type II, beta (SCN2B),mRNAImported
Gene namesi
Name:SCN2BImported
ORF Names:hCG_41149Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei158 – 180HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500878162130 – 215Sequence analysisAdd BLAST186

Expressioni

Gene expression databases

BgeeiENSG00000149575.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000278947.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 131Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST106

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410II8M. Eukaryota.
ENOG4111M25. LUCA.
HOVERGENiHBG003443.
KOiK04846.
OMAiHGKIYLQ.
OrthoDBiEOG091G0O9E.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029873. SCN2B.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF3. PTHR13869:SF3. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U0K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC
60 70 80 90 100
TFNSCYTVNH KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE
110 120 130 140 150
FSGNPSKYDV SVMLRNVQPE DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE
160 170 180 190 200
PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE
210
EGKTDGEGNP DDGAK
Length:215
Mass (Da):24,326
Last modified:May 10, 2005 - v1
Checksum:i94A30A60A32683F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019487 mRNA. Translation: AAV38294.1.
AK313891 mRNA. Translation: BAG36614.1.
CH471065 Genomic DNA. Translation: EAW67353.1.
RefSeqiNP_004579.1. NM_004588.4.
UniGeneiHs.129783.

Genome annotation databases

GeneIDi6327.
KEGGihsa:6327.
UCSCiuc001psf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019487 mRNA. Translation: AAV38294.1.
AK313891 mRNA. Translation: BAG36614.1.
CH471065 Genomic DNA. Translation: EAW67353.1.
RefSeqiNP_004579.1. NM_004588.4.
UniGeneiHs.129783.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000278947.

Protocols and materials databases

DNASUi6327.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6327.
KEGGihsa:6327.
UCSCiuc001psf.3. human.

Organism-specific databases

CTDi6327.
PharmGKBiPA303.

Phylogenomic databases

eggNOGiENOG410II8M. Eukaryota.
ENOG4111M25. LUCA.
HOVERGENiHBG003443.
KOiK04846.
OMAiHGKIYLQ.
OrthoDBiEOG091G0O9E.

Miscellaneous databases

ChiTaRSiSCN2B. human.
GenomeRNAii6327.

Gene expression databases

BgeeiENSG00000149575.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029873. SCN2B.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF3. PTHR13869:SF3. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U0K8_HUMAN
AccessioniPrimary (citable) accession number: Q5U0K8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.