Q5U0F4 (Q5U0F4_HUMAN) Unreviewed, UniProtKB/TrEMBL
Last modified July 9, 2014. Version 66. History...
Names and origin
|Protein names||Recommended name:|
Eukaryotic translation initiation factor 3 subunit I HAMAP-Rule MF_03008
Short name=eIF3i HAMAP-Rule MF_03008
|Organism||Homo sapiens (Human) EMBL AAV38404.1|
|Taxonomic identifier||9606 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo|
|Sequence length||325 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation By similarity. HAMAP-Rule MF_03008
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3 By similarity. HAMAP-Rule MF_03008
Phosphorylated by TGF-beta type II receptor By similarity. HAMAP-Rule MF_03008
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Repeat||8 – 47||40||WD 1 By similarity HAMAP-Rule MF_03008|
|Repeat||50 – 91||42||WD 2 By similarity HAMAP-Rule MF_03008|
|Repeat||144 – 183||40||WD 3 By similarity HAMAP-Rule MF_03008|
|Repeat||186 – 225||40||WD 4 By similarity HAMAP-Rule MF_03008|
|Repeat||283 – 324||42||WD 5 By similarity HAMAP-Rule MF_03008|
|BT019597 mRNA. Translation: AAV38404.1.|
AK289356 mRNA. Translation: BAF82045.1.
AK289882 mRNA. Translation: BAF82571.1.
CH471059 Genomic DNA. Translation: EAX07553.1.
|RefSeq||NP_003748.1. NM_003757.2. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|Gene3D||18.104.22.168. 1 hit. |
|HAMAP||MF_03008. eIF3i. |
|InterPro||IPR027525. eIF3i. |
|Pfam||PF00400. WD40. 4 hits. |
|SMART||SM00320. WD40. 5 hits. |
|SUPFAM||SSF50978. SSF50978. 1 hit. |
|PROSITE||PS00678. WD_REPEATS_1. 1 hit. |
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
|ChiTaRS||EIF3I. human. |
|Accession||Primary (citable) accession number: Q5U0F4|
|Entry status||Unreviewed (UniProtKB/TrEMBL)|
|Disclaimer||Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.|