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Unreviewed, UniProtKB/TrEMBL Q5U0E4 (Q5U0E4_HUMAN)

Last modified January 19, 2010. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesRecommended name:
    Cellular tumor antigen p53 RuleBase RU003304V0
OrganismHomo sapiens (Human) EMBL AAV38428.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity. RuleBase RU003304V0

Subunit structure

Binds DNA as a homotetramer By similarity. RuleBase RU003304V0

Subcellular location

Cytoplasm. Nucleus By similarity RuleBase RU003304V0.

Sequence similarities

Belongs to the p53 family.

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Ontologies

Keywords
   Biological processApoptosis RuleBase RU003304V0
Cell cycle RuleBase RU003304V0
Transcription
Transcription regulation RuleBase RU003304V0 Spearmint SPM012346
   Cellular componentNucleus RuleBase RU003401V0 Spearmint SPM012346
   LigandDNA-binding RuleBase RU003304V0
Metal-binding RuleBase RU003304V0
Zinc RuleBase RU003304V0
   Molecular functionActivator RuleBase RU003304V0
   PTMPhosphoprotein RuleBase RU003304V0
Gene Ontology (GO)
   Biological processB cell lineage commitment

Inferred from electronic annotation. Source: Compara

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

Inferred from electronic annotation. Source: Compara

G1/S DNA damage checkpoint

Inferred from electronic annotation. Source: Compara

T cell differentiation in the thymus

Inferred from electronic annotation. Source: Compara

T cell lineage commitment

Inferred from electronic annotation. Source: Compara

T cell proliferation during immune response

Inferred from electronic annotation. Source: Compara

cell aging

Inferred from electronic annotation. Source: Compara

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to UV

Inferred from electronic annotation. Source: Compara

central nervous system development

Inferred from electronic annotation. Source: Compara

chromosome organization

Inferred from electronic annotation. Source: Compara

double-strand break repair

Inferred from electronic annotation. Source: Compara

gastrulation

Inferred from electronic annotation. Source: Compara

in utero embryonic development

Inferred from electronic annotation. Source: Compara

negative regulation of DNA replication

Inferred from electronic annotation. Source: Compara

negative regulation of apoptosis

Inferred from electronic annotation. Source: Compara

negative regulation of cell growth

Inferred from electronic annotation. Source: InterPro

negative regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Compara

negative regulation of neuroblast proliferation

Inferred from electronic annotation. Source: Compara

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Compara

positive regulation of neuron apoptosis

Inferred from electronic annotation. Source: Compara

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Compara

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Compara

rRNA transcription

Inferred from electronic annotation. Source: Compara

regulation of mitochondrial membrane permeability

Inferred from electronic annotation. Source: Compara

release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Compara

response to X-ray

Inferred from electronic annotation. Source: Compara

response to drug

Inferred from electronic annotation. Source: Compara

response to gamma radiation

Inferred from electronic annotation. Source: Compara

response to salt stress

Inferred from electronic annotation. Source: Compara

response to tumor cell

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytosol

Inferred from electronic annotation. Source: Compara

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

replication fork

Inferred from electronic annotation. Source: Compara

   Molecular functionprotein binding

Inferred from electronic annotation. Source: Compara

transcription factor activity

Inferred from electronic annotation. Source: Compara

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q5U0E4-1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 6610C5F3491C530E

FASTA39343,730
        10         20         30         40         50         60 
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP 

        70         80         90        100        110        120 
DEAPRMPEAA PRVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK 

       130        140        150        160        170        180 
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE 

       190        200        210        220        230        240 
RCSDSDGMAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS 

       250        260        270        280        290        300 
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP 

       310        320        330        340        350        360 
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG 

       370        380        390 
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD

« Hide

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References

[1]"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT019622 mRNA. Translation: AAV38428.1.
IPIIPI00025087.
UniGeneHs.654481

3D structure databases

SMRQ5U0E4. Positions 94-297, 319-360.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5U0E4.

Genome annotation databases

EnsemblENST00000269305; ENSP00000269305; ENSG00000141510; Homo sapiens. [Genome view]
ENST00000445888; ENSP00000391478; ENSG00000141510; Homo sapiens. [Genome view]

Organism-specific databases

HGNCHGNC:11998. TP53.

Phylogenomic databases

HOVERGENQ5U0E4.

Gene expression databases

ArrayExpressQ5U0E4.
BgeeQ5U0E4.

Family and domain databases

InterProIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA_bd.
IPR011615. p53_DNA_bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_Ag.
IPR015551. Trp53.
[Graphical view]
Gene3DG3DSA:2.60.40.720. p53_RUNT_DNA_bd. 1 hit.
G3DSA:4.10.170.10. p53_tetrameristn. 1 hit.
PANTHERPTHR11447. Trp53. 1 hit.
PfamPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSPR00386. P53SUPPRESSR.
PROSITEPS00348. P53. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ5U0E4_HUMAN
AccessionPrimary (citable) accession number: Q5U0E4
Entry history
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: January 19, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information