Unreviewed, UniProtKB/TrEMBL Q5U091 (Q5U091_HUMAN)

Names and origin

Protein names

Submitted name:
    Neuroblastoma RAS viral (V-ras) oncogene homolog EMBL AAV38540.1
Submitted name:
    Neuroblastoma RAS viral (V-ras) oncogene homolog, isoform CRA_a EMBL EAW56608.1

Gene names

Name:	NRAS EMBL EAW56608.1
ORF Names:	RP5-1000E10.2-001 EMBL CAI18827.1, hCG_38454 EMBL EAW56608.1

Organism

Homo sapiens (Human) EMBL AAV38540.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Ligand	GTP-binding RuleBase RU003312V0 Spearmint SPM003577 Nucleotide-binding
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara endocytosis Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptosis Inferred from electronic annotation. Source: Compara positive regulation of Rac protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro striated muscle cell differentiation Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: InterPro membrane fraction Inferred from electronic annotation. Source: Compara
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5U091-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 6898D3F6815B1EC7	FASTA	189	21,229
	10 20 30 40 50 60 MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 70 80 90 100 110 120 QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL 130 140 150 160 170 180 PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM

References

[1]	"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O., Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Grafham D. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT019734 mRNA. Translation: AAV38539.1. BT019735 mRNA. Translation: AAV38540.1. EU332857 Genomic DNA. Translation: ABY87546.1. AL096773 Genomic DNA. Translation: CAI18827.1. CH471122 Genomic DNA. Translation: EAW56608.1.
IPI	IPI00000005.
RefSeq	NP_002515.1.
UniGene	Hs.486502
3D structure databases
SMR	Q5U091. Positions 1-166.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5U091.
Proteomic databases
PRIDE	Q5U091.
Genome annotation databases
Ensembl	ENST00000369535; ENSP00000358548; ENSG00000213281; Homo sapiens. [Genome view]
GeneID	4893.
KEGG	hsa:4893.
Organism-specific databases
CTD	4893.
HGNC	HGNC:7989. NRAS.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5U091.
OMA	EDGNQGC.
PhylomeDB	Q5U091.
Gene expression databases
ArrayExpress	Q5U091.
Bgee	Q5U091.
Family and domain databases
InterPro	IPR003577. GTPase_Ras. IPR013753. Ras. IPR001806. Ras_GTPase. IPR015592. Ras_Ras_related. IPR020849. Ras_small_GTPase. IPR005225. Small_GTP_bd. [Graphical view]
PANTHER	PTHR11708:SF125. Ras_Ras_related. 1 hit.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00173. RAS. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51421. RAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	18835.

Entry information

Entry name

Q5U091_HUMAN

Accession

Primary (citable) accession number: Q5U091

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.