Q5U077 (Q5U077_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
L-lactate dehydrogenase RuleBase RU000496
EC=1.1.1.27 RuleBase RU000496

Gene names

Name:	LDHB EMBL ACF98331.1
ORF Names:	hCG_24788 EMBL EAW96448.1

Organism

Homo sapiens (Human) EMBL AAV38570.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-lactate + NAD+ = pyruvate + NADH. RuleBase RU000496
Pathway	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. RuleBase RU000496
Sequence similarities	Belongs to the LDH/MDH superfamily. LDH family. RuleBase RU004149

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000496
Ligand	NAD RuleBase RU000496
Molecular function	Oxidoreductase RuleBase RU000496
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5U077 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 3AD605DEED0D54A2	FASTA	334	36,638
	10 20 30 40 50 60 MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK 70 80 90 100 110 120 GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF 130 140 150 160 170 180 IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG 190 200 210 220 230 240 IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY 250 260 270 280 290 300 EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG 310 320 330 LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDL

References

[1]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Cerebellum EMBL BAG35250.1.
[2]	Rieder M.J., Johanson E.J., da Ponte S.H., Stanaway I.B., Ahearn M.O., Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Identification of human transforming gene 5." Kim J.W. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY189689 mRNA. Translation: AAO85222.1. BT019764 mRNA. Translation: AAV38569.1. BT019765 mRNA. Translation: AAV38570.1. EU919185 Genomic DNA. Translation: ACF98331.1. AK312328 mRNA. Translation: BAG35250.1. CH471094 Genomic DNA. Translation: EAW96448.1.
IPI	IPI00219217.
RefSeq	NP_001167568.1. NM_001174097.1. NP_002291.1. NM_002300.6.
UniGene	Hs.446149.
3D structure databases
ProteinModelPortal	Q5U077.
SMR	Q5U077. Positions 2-333.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5U077.
Proteomic databases
PRIDE	Q5U077.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3945.
KEGG	hsa:3945.
NMPDR	fig|9606.3.peg.7290.
Organism-specific databases
CTD	3945.
Phylogenomic databases
GeneTree	ENSGT00550000074541.
HOVERGEN	HBG000462.
OMA	YSPDCTI.
PhylomeDB	Q5U077.
Gene expression databases
ArrayExpress	Q5U077.
Bgee	Q5U077.
Family and domain databases
HAMAP	MF_00488. Lactate_dehydrog. [Tree]
InterPro	IPR001557. L-lactate/malate_DH. IPR011304. L-lactate_DH. IPR018177. L-lactate_DH_AS. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00016.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01771. L-LDH-NAD. 1 hit.
PROSITE	PS00064. L_LDH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	15479.

Entry information

Entry name

Q5U077_HUMAN

Accession

Primary (citable) accession number: Q5U077

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.