CCR1

Functionⁱ

GO - Molecular functionⁱ

C-C chemokine receptor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

chemotaxis Source: InterPro
immune response Source: InterPro
inflammatory response Source: InterPro
positive regulation of monocyte chemotaxis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Chemokine (C-C motif) receptor 1Imported Submitted name: Chemokine (C-C motif) receptor 1, isoform CRA_aImported
Gene namesⁱ	Name:CCR1Imported ORF Names:hCG_15324Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	40 – 60	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	72 – 91	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	111 – 134	HelicalSequence analysisAdd BLAST	24
Transmembraneⁱ	146 – 170	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	205 – 227	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	239 – 261	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	281 – 304	HelicalSequence analysisAdd BLAST	24

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA26166.

PharmGKBⁱ

PA26166.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163823.
ExpressionAtlasⁱ	Q5U003. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q5U003.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	51 – 301	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		251

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
HOVERGENⁱ	HBG106917.
KEGG Orthology (KO) More...KOⁱ	K04176.
OMAⁱ	LHFPHES.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B7A.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002236. Chemokine_CCR1. IPR034321. Chemokine_CCR1_euk. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM.
PANTHERⁱ	PTHR10489:SF869. PTHR10489:SF869. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00657. CCCHEMOKINER. PR01106. CHEMOKINER1. PR00237. GPCRRHODOPSN.
SMARTⁱ	View protein in SMART SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5U003-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV 
        60         70         80         90        100
GNILVVLVLV QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV 
       110        120        130        140        150
FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG 
       160        170        180        190        200
VITSIIIWAL AILASMPGLY FSKTQWEFTH HTCSLHFPHE SLREWKLFQA 
       210        220        230        240        250
LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL 
       260        270        280        290        300
FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI 
       310        320        330        340        350
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE 

LSAGF

Length:355

Mass (Da):41,173

Last modified:May 10, 2005 - v1

Checksum:ⁱB2C100FFED275985

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT019908 mRNA. Translation: AAV38711.1. BT019909 mRNA. Translation: AAV38712.1. CH471055 Genomic DNA. Translation: EAW64756.1. CH471055 Genomic DNA. Translation: EAW64757.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001286.1. NM_001295.2.
UniGeneⁱ	Hs.301921.

Genome annotation databases

GeneIDⁱ	1230.
KEGGⁱ	hsa:1230.
UCSC genome browser More...UCSCⁱ	uc003cph.2. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT019908 mRNA. Translation: AAV38711.1. BT019909 mRNA. Translation: AAV38712.1. CH471055 Genomic DNA. Translation: EAW64756.1. CH471055 Genomic DNA. Translation: EAW64757.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001286.1. NM_001295.2.
UniGeneⁱ	Hs.301921.

3D structure databases

SMRⁱ	Q5U003.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1230.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	1230.
KEGGⁱ	hsa:1230.
UCSC genome browser More...UCSCⁱ	uc003cph.2. human.

Organism-specific databases

CTDⁱ	1230.
PharmGKBⁱ	PA26166.

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
HOVERGENⁱ	HBG106917.
KEGG Orthology (KO) More...KOⁱ	K04176.
OMAⁱ	LHFPHES.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B7A.

Miscellaneous databases

GenomeRNAiⁱ	1230.

GenomeRNAiⁱ

1230.

Gene expression databases

Bgeeⁱ	ENSG00000163823.
ExpressionAtlasⁱ	Q5U003. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002236. Chemokine_CCR1. IPR034321. Chemokine_CCR1_euk. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM.
PANTHERⁱ	PTHR10489:SF869. PTHR10489:SF869. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00657. CCCHEMOKINER. PR01106. CHEMOKINER1. PR00237. GPCRRHODOPSN.
SMARTⁱ	View protein in SMART SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5U003_HUMAN
Accessionⁱ	Q5U003Primary (citable) accession number: Q5U003
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	July 5, 2017
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Annotation systems

Supporting data

UniProtKB - Q5U003 (Q5U003_HUMAN)

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Chemokine (C-C motif) receptor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ