UniProtKB - Q5U003 (Q5U003_HUMAN)
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Protein
Submitted name:
Chemokine (C-C motif) receptor 1
Gene
CCR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- C-C chemokine receptor activity Source: InterPro
GO - Biological processi
- chemotaxis Source: InterPro
- immune response Source: InterPro
- inflammatory response Source: InterPro
- positive regulation of monocyte chemotaxis Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Chemokine (C-C motif) receptor 1ImportedSubmitted name: Chemokine (C-C motif) receptor 1, isoform CRA_aImported |
Gene namesi | Name:CCR1Imported ORF Names:hCG_15324Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163823.3. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 40 – 60 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 72 – 91 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 111 – 134 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 146 – 170 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 205 – 227 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 239 – 261 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 281 – 304 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 301 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 251 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | KOG3656. Eukaryota. ENOG410XRW9. LUCA. |
HOVERGENi | HBG106917. |
KOi | K04176. |
OMAi | LHFPHES. |
OrthoDBi | EOG091G0B7A. |
Family and domain databases
InterProi | View protein in InterPro IPR002236. Chemokine_CCR1. IPR034321. Chemokine_CCR1_euk. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. |
PANTHERi | PTHR10489:SF711. PTHR10489:SF711. 1 hit. |
Pfami | View protein in Pfam PF00001. 7tm_1. 1 hit. |
PRINTSi | PR00657. CCCHEMOKINER. PR01106. CHEMOKINER1. PR00237. GPCRRHODOPSN. |
SMARTi | View protein in SMART SM01381. 7TM_GPCR_Srsx. 1 hit. |
PROSITEi | View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q5U003-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV
60 70 80 90 100
GNILVVLVLV QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV
110 120 130 140 150
FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIIIWAL AILASMPGLY FSKTQWEFTH HTCSLHFPHE SLREWKLFQA
210 220 230 240 250
LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL
260 270 280 290 300
FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI
310 320 330 340 350
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE
LSAGF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019908 mRNA. Translation: AAV38711.1. BT019909 mRNA. Translation: AAV38712.1. CH471055 Genomic DNA. Translation: EAW64756.1. CH471055 Genomic DNA. Translation: EAW64757.1. |
RefSeqi | NP_001286.1. NM_001295.2. |
UniGenei | Hs.301921. |
Genome annotation databases
GeneIDi | 1230. |
KEGGi | hsa:1230. |
UCSCi | uc003cph.2. human. |
Similar proteinsi
Entry informationi
Entry namei | Q5U003_HUMAN | |
Accessioni | Q5U003Primary (citable) accession number: Q5U003 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | March 28, 2018 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |