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Q5TZZ9

- Q5TZZ9_HUMAN

UniProt

Q5TZZ9 - Q5TZZ9_HUMAN

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Protein

Annexin

Gene

ANXA1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. phospholipase A2 inhibitor activity Source: Ensembl

GO - Biological processi

  1. alpha-beta T cell differentiation Source: Ensembl
  2. arachidonic acid secretion Source: Ensembl
  3. cell surface receptor signaling pathway Source: Ensembl
  4. cellular response to glucocorticoid stimulus Source: Ensembl
  5. cellular response to hydrogen peroxide Source: Ensembl
  6. endocrine pancreas development Source: Ensembl
  7. estrous cycle phase Source: Ensembl
  8. gliogenesis Source: Ensembl
  9. hepatocyte differentiation Source: Ensembl
  10. insulin secretion Source: Ensembl
  11. negative regulation of acute inflammatory response Source: Ensembl
  12. negative regulation of apoptotic process Source: Ensembl
  13. negative regulation of protein secretion Source: Ensembl
  14. neutrophil homeostasis Source: Ensembl
  15. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  16. positive regulation of neutrophil apoptotic process Source: Ensembl
  17. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  18. regulation of cell proliferation Source: Ensembl
  19. response to drug Source: Ensembl
  20. response to estradiol Source: Ensembl
  21. response to interleukin-1 Source: Ensembl
  22. response to peptide hormone Source: Ensembl
  23. response to X-ray Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA1Imported
ORF Names:hCG_17305Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. extracellular space Source: Ensembl
  3. mitochondrial membrane Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: HPA
  6. protein complex Source: Ensembl
  7. sarcolemma Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24823.

Expressioni

Gene expression databases

ExpressionAtlasiQ5TZZ9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5TZZ9.
SMRiQ5TZZ9. Positions 2-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 4 annexin repeats.UniRule annotation
Contains annexin repeats.SAAS annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118972.
HOVERGENiHBG061815.
KOiK17091.
OMAiGTRHKTL.
PhylomeDBiQ5TZZ9.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TZZ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL
110 120 130 140 150
TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR
160 170 180 190 200
DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD
210 220 230 240 250
SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK
260 270 280 290 300
VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM
310 320 330 340
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN
Length:346
Mass (Da):38,714
Last modified:May 10, 2005 - v1
Checksum:i14B42E1FA4178EC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei346 – 3461Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT019896 mRNA. Translation: AAV38699.1.
BT019916 mRNA. Translation: AAV38719.1.
BT019917 mRNA. Translation: AAV38720.1.
GU997628 Genomic DNA. Translation: ADZ76495.1.
CR407684 mRNA. Translation: CAG28612.1.
CH471089 Genomic DNA. Translation: EAW62545.1.
CH471089 Genomic DNA. Translation: EAW62547.1.
CH471089 Genomic DNA. Translation: EAW62549.1.
CH471089 Genomic DNA. Translation: EAW62550.1.
RefSeqiNP_000691.1. NM_000700.1.
UniGeneiHs.494173.

Genome annotation databases

GeneIDi301.
KEGGihsa:301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT019896 mRNA. Translation: AAV38699.1 .
BT019916 mRNA. Translation: AAV38719.1 .
BT019917 mRNA. Translation: AAV38720.1 .
GU997628 Genomic DNA. Translation: ADZ76495.1 .
CR407684 mRNA. Translation: CAG28612.1 .
CH471089 Genomic DNA. Translation: EAW62545.1 .
CH471089 Genomic DNA. Translation: EAW62547.1 .
CH471089 Genomic DNA. Translation: EAW62549.1 .
CH471089 Genomic DNA. Translation: EAW62550.1 .
RefSeqi NP_000691.1. NM_000700.1.
UniGenei Hs.494173.

3D structure databases

ProteinModelPortali Q5TZZ9.
SMRi Q5TZZ9. Positions 2-344.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 301.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 301.
KEGGi hsa:301.

Organism-specific databases

CTDi 301.
PharmGKBi PA24823.

Phylogenomic databases

GeneTreei ENSGT00760000118972.
HOVERGENi HBG061815.
KOi K17091.
OMAi GTRHKTL.
PhylomeDBi Q5TZZ9.

Miscellaneous databases

ChiTaRSi ANXA1. human.
GenomeRNAii 301.
NextBioi 1213.

Gene expression databases

ExpressionAtlasi Q5TZZ9. baseline and differential.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view ]
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: NUCLEOTIDE SEQUENCE.
  5. Perez Solis E.E.
    Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5TZZ9_HUMAN
AccessioniPrimary (citable) accession number: Q5TZZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.