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Q5TZZ9

- Q5TZZ9_HUMAN

UniProt

Q5TZZ9 - Q5TZZ9_HUMAN

Protein

Annexin

Gene

ANXA1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. phospholipase A2 inhibitor activity Source: Ensembl

    GO - Biological processi

    1. alpha-beta T cell differentiation Source: Ensembl
    2. arachidonic acid secretion Source: Ensembl
    3. cell surface receptor signaling pathway Source: Ensembl
    4. cellular response to glucocorticoid stimulus Source: Ensembl
    5. cellular response to hydrogen peroxide Source: Ensembl
    6. endocrine pancreas development Source: Ensembl
    7. estrous cycle phase Source: Ensembl
    8. gliogenesis Source: Ensembl
    9. hepatocyte differentiation Source: Ensembl
    10. insulin secretion Source: Ensembl
    11. negative regulation of acute inflammatory response Source: Ensembl
    12. negative regulation of apoptotic process Source: Ensembl
    13. negative regulation of protein secretion Source: Ensembl
    14. neutrophil homeostasis Source: Ensembl
    15. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    16. positive regulation of neutrophil apoptotic process Source: Ensembl
    17. positive regulation of prostaglandin biosynthetic process Source: Ensembl
    18. regulation of cell proliferation Source: Ensembl
    19. response to drug Source: Ensembl
    20. response to estradiol Source: Ensembl
    21. response to interleukin-1 Source: Ensembl
    22. response to peptide hormone Source: Ensembl
    23. response to X-ray Source: Ensembl

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AnnexinUniRule annotation
    Gene namesi
    Name:ANXA1Imported
    ORF Names:hCG_17305Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular space Source: Ensembl
    3. mitochondrial membrane Source: Ensembl
    4. nucleus Source: Ensembl
    5. plasma membrane Source: HPA
    6. protein complex Source: Ensembl
    7. sarcolemma Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24823.

    Structurei

    3D structure databases

    SMRiQ5TZZ9. Positions 2-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

    Sequence similaritiesi

    Belongs to the annexin family.UniRule annotation
    Contains 4 annexin repeats.UniRule annotation
    Contains annexin repeats.SAAS annotation

    Keywords - Domaini

    AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG061815.
    KOiK17091.
    OMAiGTRHKTL.
    PhylomeDBiQ5TZZ9.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002388. AnnexinI.
    [Graphical view]
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00197. ANNEXINI.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5TZZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA    50
    LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL 100
    TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR 150
    DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD 200
    SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK 250
    VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM 300
    VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN 346
    Length:346
    Mass (Da):38,714
    Last modified:May 10, 2005 - v1
    Checksum:i14B42E1FA4178EC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei346 – 3461Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT019896 mRNA. Translation: AAV38699.1.
    BT019916 mRNA. Translation: AAV38719.1.
    BT019917 mRNA. Translation: AAV38720.1.
    GU997628 Genomic DNA. Translation: ADZ76495.1.
    CR407684 mRNA. Translation: CAG28612.1.
    CH471089 Genomic DNA. Translation: EAW62545.1.
    CH471089 Genomic DNA. Translation: EAW62547.1.
    CH471089 Genomic DNA. Translation: EAW62549.1.
    CH471089 Genomic DNA. Translation: EAW62550.1.
    RefSeqiNP_000691.1. NM_000700.1.
    UniGeneiHs.494173.

    Genome annotation databases

    GeneIDi301.
    KEGGihsa:301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT019896 mRNA. Translation: AAV38699.1 .
    BT019916 mRNA. Translation: AAV38719.1 .
    BT019917 mRNA. Translation: AAV38720.1 .
    GU997628 Genomic DNA. Translation: ADZ76495.1 .
    CR407684 mRNA. Translation: CAG28612.1 .
    CH471089 Genomic DNA. Translation: EAW62545.1 .
    CH471089 Genomic DNA. Translation: EAW62547.1 .
    CH471089 Genomic DNA. Translation: EAW62549.1 .
    CH471089 Genomic DNA. Translation: EAW62550.1 .
    RefSeqi NP_000691.1. NM_000700.1.
    UniGenei Hs.494173.

    3D structure databases

    SMRi Q5TZZ9. Positions 2-344.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 301.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 301.
    KEGGi hsa:301.

    Organism-specific databases

    CTDi 301.
    PharmGKBi PA24823.

    Phylogenomic databases

    HOVERGENi HBG061815.
    KOi K17091.
    OMAi GTRHKTL.
    PhylomeDBi Q5TZZ9.

    Miscellaneous databases

    ChiTaRSi ANXA1. human.
    GenomeRNAii 301.
    NextBioi 1213.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002388. AnnexinI.
    [Graphical view ]
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00197. ANNEXINI.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Cited for: NUCLEOTIDE SEQUENCE.
    5. Perez Solis E.E.
      Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ5TZZ9_HUMAN
    AccessioniPrimary (citable) accession number: Q5TZZ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.