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Protein

Annexin

Gene

ANXA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA1Imported
ORF Names:hCG_17305Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24823.

Expressioni

Gene expression databases

BgeeiENSG00000135046.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000257497.

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 4 annexin repeats.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOVERGENiHBG061815.
KOiK17091.
OMAiIMVSRHE.
OrthoDBiEOG091G0H6H.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view]
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TZZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL
110 120 130 140 150
TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR
160 170 180 190 200
DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD
210 220 230 240 250
SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK
260 270 280 290 300
VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM
310 320 330 340
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN
Length:346
Mass (Da):38,714
Last modified:May 10, 2005 - v1
Checksum:i14B42E1FA4178EC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei346Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019896 mRNA. Translation: AAV38699.1.
BT019916 mRNA. Translation: AAV38719.1.
BT019917 mRNA. Translation: AAV38720.1.
GU997628 Genomic DNA. Translation: ADZ76495.1.
CR407684 mRNA. Translation: CAG28612.1.
CH471089 Genomic DNA. Translation: EAW62545.1.
CH471089 Genomic DNA. Translation: EAW62547.1.
CH471089 Genomic DNA. Translation: EAW62549.1.
CH471089 Genomic DNA. Translation: EAW62550.1.
RefSeqiNP_000691.1. NM_000700.2.
XP_011516911.1. XM_011518609.1.
UniGeneiHs.494173.

Genome annotation databases

GeneIDi301.
KEGGihsa:301.
UCSCiuc004ajf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019896 mRNA. Translation: AAV38699.1.
BT019916 mRNA. Translation: AAV38719.1.
BT019917 mRNA. Translation: AAV38720.1.
GU997628 Genomic DNA. Translation: ADZ76495.1.
CR407684 mRNA. Translation: CAG28612.1.
CH471089 Genomic DNA. Translation: EAW62545.1.
CH471089 Genomic DNA. Translation: EAW62547.1.
CH471089 Genomic DNA. Translation: EAW62549.1.
CH471089 Genomic DNA. Translation: EAW62550.1.
RefSeqiNP_000691.1. NM_000700.2.
XP_011516911.1. XM_011518609.1.
UniGeneiHs.494173.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000257497.

Protocols and materials databases

DNASUi301.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301.
KEGGihsa:301.
UCSCiuc004ajf.2. human.

Organism-specific databases

CTDi301.
PharmGKBiPA24823.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOVERGENiHBG061815.
KOiK17091.
OMAiIMVSRHE.
OrthoDBiEOG091G0H6H.

Miscellaneous databases

ChiTaRSiANXA1. human.
GenomeRNAii301.

Gene expression databases

BgeeiENSG00000135046.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view]
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TZZ9_HUMAN
AccessioniPrimary (citable) accession number: Q5TZZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.