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Protein
Submitted name:

Three prime repair exonuclease 1, isoform CRA_g

Gene

TREX1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionExonucleaseImported, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Submitted name:
Three prime repair exonuclease 1, isoform CRA_gImported
Gene namesi
Name:TREX1Imported
ORF Names:hCG_1997849Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000282827.1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ5TZT0

Expressioni

Gene expression databases

BgeeiENSG00000282827
ExpressionAtlasiQ5TZT0 baseline

Interactioni

Protein-protein interaction databases

IntActiQ5TZT0, 3 interactors

Structurei

3D structure databases

SMRiQ5TZT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 207ExonucleaseInterPro annotationAdd BLAST205

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4793 Eukaryota
ENOG4111YSP LUCA
HOGENOMiHOG000118119
HOVERGENiHBG079278

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TZT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLIFFDME ATGLPFSQPK VTELCLLAVH RCALESPPTS QGPPPTVPPP
60 70 80 90 100
PRVVDKLSLC VAPGKACSPA ASEITGLSTA VLAAHGRQCF DDNLANLLLA
110 120 130 140 150
FLRRQPQPWC LVAHNGDRYD FPLLQAELAM LGLTSALDGA FCVDSITALK
160 170 180 190 200
ALERASSPSE HGPRKSYSLG SIYTRLYGQS PPDSHTAEGD VLALLSICQW
210 220 230 240 250
RPQALLRWVD AHARPFGTIR PMYGVTASAR TKPRPSAVTT TAHLATTRNT
260 270 280 290 300
SPSLGESRGT KDLPPVKDPG ALSREGLLAP LGLLAILTLA VATLYGLSLA

TPGE
Length:304
Mass (Da):32,276
Last modified:May 10, 2005 - v1
Checksum:i922048DCC4122124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020052 mRNA Translation: AAV38855.1
BT020053 mRNA Translation: AAV38856.1
CH471055 Genomic DNA Translation: EAW64883.1
RefSeqiNP_009179.2, NM_007248.3
UniGeneiHs.707026
Hs.713742
Hs.744646

Genome annotation databases

GeneIDi11277

Similar proteinsi

Entry informationi

Entry nameiQ5TZT0_HUMAN
AccessioniPrimary (citable) accession number: Q5TZT0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 20, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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