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Protein

Delta-like protein

Gene

jag2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • liver development Source: ZFIN
  • Notch signaling pathway Source: InterPro
  • pancreas development Source: ZFIN
  • pronephros development Source: ZFIN
  • regulation of cell proliferation Source: InterPro
  • spinal cord motor neuron differentiation Source: ZFIN
  • ventral spinal cord interneuron differentiation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-1980148. Signaling by NOTCH3.
R-DRE-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:jag2bImported
Synonyms:jag2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-011128-3. jag2b.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1084 – 1107HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: ZFIN
  • integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500426254327 – 1254Delta-like proteinSequence analysisAdd BLAST1228

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PaxDbiQ5TZK8.

Expressioni

Gene expression databases

BgeeiENSDARG00000021389.
ExpressionAtlasiQ5TZK8. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010799.

Structurei

3D structure databases

ProteinModelPortaliQ5TZK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 232DSLInterPro annotationAdd BLAST45
Domaini266 – 297EGF-likeInterPro annotationAdd BLAST32
Domaini299 – 337EGF-likeInterPro annotationAdd BLAST39
Domaini339 – 375EGF-likeInterPro annotationAdd BLAST37
Domaini377 – 413EGF-likeInterPro annotationAdd BLAST37
Domaini415 – 451EGF-likeInterPro annotationAdd BLAST37
Domaini453 – 489EGF-likeInterPro annotationAdd BLAST37
Domaini491 – 527EGF-likeInterPro annotationAdd BLAST37
Domaini533 – 569EGF-likeInterPro annotationAdd BLAST37
Domaini596 – 635EGF-likeInterPro annotationAdd BLAST40
Domaini637 – 673EGF-likeInterPro annotationAdd BLAST37
Domaini675 – 711EGF-likeInterPro annotationAdd BLAST37
Domaini713 – 749EGF-likeInterPro annotationAdd BLAST37
Domaini752 – 788EGF-likeInterPro annotationAdd BLAST37
Domaini790 – 826EGF-likeInterPro annotationAdd BLAST37
Domaini828 – 864EGF-likeInterPro annotationAdd BLAST37

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOVERGENiHBG031645.
InParanoidiQ5TZK8.
OMAiHHPCTNG.
OrthoDBiEOG091G0A88.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR033108. Jag2.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR24044:SF316. PTHR24044:SF316. 1 hit.
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 12 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TZK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNCIRIRNW LPIACLLLTM WTKVSQSSGY FELQLIAVEN VNGELWDGEC
60 70 80 90 100
CDSTRNSQDQ RCVRDECDTY FKVCLKEYQS EVTTTGQCTF GSGSTDVLGG
110 120 130 140 150
NIISFKTAKN SPSKTSDVGK IIIPFHFAWP RSYTLILEAW DWDNSTQNNG
160 170 180 190 200
EENLIERHIH ASMVNPGDHW QSIRHPGITA HIEYRIRVRC DENYYGSKCN
210 220 230 240 250
KQCRPRDDYF GHYRCDPSGN IVCLDGWMGE DCRTAICKQG CNLIHGGCAV
260 270 280 290 300
PGECKCNYGW QGQFCDECLP YPGCLHGTCV MPWQCTCEKN WGGLLCDKDL
310 320 330 340 350
NYCGTHHPCV NGGTCMNSEP DEYNCACPEG YSGKNCEIAE HACVSNPCAN
360 370 380 390 400
GGTCHEVPTG FECHCPPGWE GPTCAKDMDE CASSPCAQGG TCIDLENGFE
410 420 430 440 450
CVCPPQWVGK TCQIDANECM GKPCVNAHSC KNMIGGYHCD CFQGWAGQNC
460 470 480 490 500
DINLNGCHGQ CQNGATCKEL VHGGYHCQCP AGFVGLHCEV SRNKCASGPC
510 520 530 540 550
QNGGRCHVIL DSFVCECPSN YAGMLCEVES LSHPNPCEPN PCQNTALCYS
560 570 580 590 600
LPGDFYCACP EDYEGKTCEN RKDHCKMTPC QVIDSCTIAV ASNSSDGGVR
610 620 630 640 650
HINSNVCGPH GRCISQPGGN FTCTCELGFT GTYCHENVND CVSNPCRNGG
660 670 680 690 700
TCIDGISSFQ CFCPDGWEGD LCSINVNECS RSPCKNGGHC VDLVNDFYCE
710 720 730 740 750
CANGWKGKTC HSRESQCDSS TCSNGGTCYD HGDAFRCACP PGWEGSTCNT
760 770 780 790 800
AKNSTCASGP CLNGGTCVGG GDTFTCICKD GWEGATCAQN TNDCNPHPCY
810 820 830 840 850
NGGICVDGVN WFRCECAPGF AGPDCRINID ECQSSPCAYG ATCVDEINGF
860 870 880 890 900
RCVCPLGRTG PQCQEFIGIG KTCHYAGLQF PHGSRWEEEC NTCQCVNGKV
910 920 930 940 950
ECTKVVCGRK PCLLPGTPGR ELHYCPGGRE CLEHNFLTCL SPPCHQWGFC
960 970 980 990 1000
SSPETPPTLQ TKCEPNSVYL DKSCARITLI FNRDKLPTGT TVENVCSELR
1010 1020 1030 1040 1050
YMPATRSLAK DHKLLVLCDL SYKNQDAVEV AISFQQDEQP SHSQIQEAAS
1060 1070 1080 1090 1100
TIVSTLSKRH NSTVMLAVIE VKVEMPVTSQ PVDYLVPVLC VVLCVLWVFC
1110 1120 1130 1140 1150
VIVCVWWTRK RRKERERCER VPVEESVNNQ WEPLRPVTRP QHKDNRDAQF
1160 1170 1180 1190 1200
ERTKLMGSPD RTCNSGDDEE DMEEDELELV EEWCGTEGGK HPVQKYSKSA
1210 1220 1230 1240 1250
ARTKNGLICT TRSTSGSSSP SLKAAYWTGF SPKDNNCKNV NNATAGQEHK

EHCV
Length:1,254
Mass (Da):137,624
Last modified:December 7, 2004 - v1
Checksum:iD546358F912C9FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004766 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSDART00000024922; ENSDARP00000010799; ENSDARG00000021389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004766 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5TZK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010799.

Proteomic databases

PaxDbiQ5TZK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000024922; ENSDARP00000010799; ENSDARG00000021389.

Organism-specific databases

ZFINiZDB-GENE-011128-3. jag2b.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOVERGENiHBG031645.
InParanoidiQ5TZK8.
OMAiHHPCTNG.
OrthoDBiEOG091G0A88.
TreeFamiTF351835.

Enzyme and pathway databases

ReactomeiR-DRE-1980148. Signaling by NOTCH3.
R-DRE-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.

Gene expression databases

BgeeiENSDARG00000021389.
ExpressionAtlasiQ5TZK8. differential.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR033108. Jag2.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR24044:SF316. PTHR24044:SF316. 1 hit.
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 12 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TZK8_DANRE
AccessioniPrimary (citable) accession number: Q5TZK8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.