Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat domain-containing protein 45

Gene

ANKRD45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 45
Gene namesi
Name:ANKRD45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183831.6
HGNCiHGNC:24786 ANKRD45
neXtProtiNX_Q5TZF3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183831
PharmGKBiPA142672612

Polymorphism and mutation databases

BioMutaiANKRD45
DMDMi74756674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445741 – 282Ankyrin repeat domain-containing protein 45Add BLAST282

Proteomic databases

EPDiQ5TZF3
MaxQBiQ5TZF3
PaxDbiQ5TZF3
PeptideAtlasiQ5TZF3
PRIDEiQ5TZF3

PTM databases

iPTMnetiQ5TZF3
PhosphoSitePlusiQ5TZF3

Expressioni

Gene expression databases

BgeeiENSG00000183831
CleanExiHS_ANKRD45
GenevisibleiQ5TZF3 HS

Organism-specific databases

HPAiHPA031655
HPA031656
HPA031657

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA2BQ96E033EBI-10247255,EBI-10239285

Protein-protein interaction databases

BioGridi130881, 2 interactors
IntActiQ5TZF3, 3 interactors
STRINGi9606.ENSP00000331268

Structurei

3D structure databases

ProteinModelPortaliQ5TZF3
SMRiQ5TZF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 121ANK 1Add BLAST30
Repeati125 – 154ANK 2Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 42Poly-Glu8

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0100 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000008829
HOGENOMiHOG000115657
HOVERGENiHBG056753
InParanoidiQ5TZF3
OMAiTPIFTKM
OrthoDBiEOG091G0TUN
PhylomeDBiQ5TZF3
TreeFamiTF329503

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.20.1270.10, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR029048 HSP70_C_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF100934 SSF100934, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TZF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTEEAGARV WVFLELMESE GPPESESSEF FSQQEEENEE EEAQEPEETG
60 70 80 90 100
PKNPLLQPAL TGDVEGLQKI FEDPENPHHE QAMQLLLEED IVGRNLLYAA
110 120 130 140 150
CMAGQSDVIR ALAKYGVNLN EKTTRGYTLL HCAAAWGRLE TLKALVELDV
160 170 180 190 200
DIEALNFREE RARDVAARYS QTECVEFLDW ADARLTLKKY IAKVSLAVTD
210 220 230 240 250
TEKGSGKLLK EDKNTILSAC RAKNEWLETH TEASINELFE QRQQLEDIVT
260 270 280
PIFTKMTTPC QVKSAKSVTS HDQKRSQDDT SN
Length:282
Mass (Da):31,810
Last modified:December 7, 2004 - v1
Checksum:iA9FE7CF4C4D70967
GO
Isoform 2 (identifier: Q5TZF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Note: No experimental confirmation available.
Show »
Length:266
Mass (Da):29,977
Checksum:iB0ABDCB676455060
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196051 – 16Missing in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127170 mRNA Translation: BAC86865.1
AL139142 Genomic DNA No translation available.
BX248409 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90950.1
BC126353 mRNA Translation: AAI26354.1
BC126355 mRNA Translation: AAI26356.1
CCDSiCCDS1309.1 [Q5TZF3-2]
RefSeqiNP_940895.1, NM_198493.2 [Q5TZF3-2]
XP_011507768.1, XM_011509466.2 [Q5TZF3-2]
XP_011507769.1, XM_011509467.1 [Q5TZF3-2]
XP_011507770.1, XM_011509468.1 [Q5TZF3-2]
XP_011507772.1, XM_011509470.1 [Q5TZF3-2]
UniGeneiHs.130054

Genome annotation databases

EnsembliENST00000333279; ENSP00000331268; ENSG00000183831 [Q5TZF3-2]
GeneIDi339416
KEGGihsa:339416
UCSCiuc001gja.2 human [Q5TZF3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANR45_HUMAN
AccessioniPrimary (citable) accession number: Q5TZF3
Secondary accession number(s): A1A4G2, Q6ZST1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health