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Q5TZF3

- ANR45_HUMAN

UniProt

Q5TZF3 - ANR45_HUMAN

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Protein
Ankyrin repeat domain-containing protein 45
Gene
ANKRD45
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 45
Gene namesi
Name:ANKRD45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24786. ANKRD45.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Ankyrin repeat domain-containing protein 45
PRO_0000244574Add
BLAST

Proteomic databases

MaxQBiQ5TZF3.
PaxDbiQ5TZF3.
PRIDEiQ5TZF3.

Expressioni

Gene expression databases

BgeeiQ5TZF3.
CleanExiHS_ANKRD45.
GenevestigatoriQ5TZF3.

Organism-specific databases

HPAiHPA031655.
HPA031656.
HPA031657.

Interactioni

Protein-protein interaction databases

BioGridi130881. 1 interaction.
STRINGi9606.ENSP00000331268.

Structurei

3D structure databases

ProteinModelPortaliQ5TZF3.
SMRiQ5TZF3. Positions 51-178.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati92 – 12130ANK 1
Add
BLAST
Repeati125 – 15430ANK 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 428Poly-Glu

Sequence similaritiesi

Contains 2 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG292903.
HOGENOMiHOG000115657.
HOVERGENiHBG056753.
InParanoidiQ5TZF3.
OMAiRYSQTEC.
OrthoDBiEOG7K0ZD6.
PhylomeDBiQ5TZF3.
TreeFamiTF329503.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR029048. HSP70_C.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF100934. SSF100934. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5TZF3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVTEEAGARV WVFLELMESE GPPESESSEF FSQQEEENEE EEAQEPEETG    50
PKNPLLQPAL TGDVEGLQKI FEDPENPHHE QAMQLLLEED IVGRNLLYAA 100
CMAGQSDVIR ALAKYGVNLN EKTTRGYTLL HCAAAWGRLE TLKALVELDV 150
DIEALNFREE RARDVAARYS QTECVEFLDW ADARLTLKKY IAKVSLAVTD 200
TEKGSGKLLK EDKNTILSAC RAKNEWLETH TEASINELFE QRQQLEDIVT 250
PIFTKMTTPC QVKSAKSVTS HDQKRSQDDT SN 282
Length:282
Mass (Da):31,810
Last modified:December 7, 2004 - v1
Checksum:iA9FE7CF4C4D70967
GO
Isoform 2 (identifier: Q5TZF3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Note: No experimental confirmation available.

Show »
Length:266
Mass (Da):29,977
Checksum:iB0ABDCB676455060
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616Missing in isoform 2.
VSP_019605Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127170 mRNA. Translation: BAC86865.1.
BX248409, AL139142 Genomic DNA. Translation: CAH72999.1.
AL139142, BX248409 Genomic DNA. Translation: CAI20937.1.
CH471067 Genomic DNA. Translation: EAW90950.1.
BC126353 mRNA. Translation: AAI26354.1.
BC126355 mRNA. Translation: AAI26356.1.
CCDSiCCDS1309.1. [Q5TZF3-2]
RefSeqiNP_940895.1. NM_198493.2. [Q5TZF3-2]
UniGeneiHs.130054.

Genome annotation databases

EnsembliENST00000333279; ENSP00000331268; ENSG00000183831. [Q5TZF3-2]
GeneIDi339416.
KEGGihsa:339416.
UCSCiuc001gja.1. human. [Q5TZF3-1]

Polymorphism databases

DMDMi74756674.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127170 mRNA. Translation: BAC86865.1 .
BX248409 , AL139142 Genomic DNA. Translation: CAH72999.1 .
AL139142 , BX248409 Genomic DNA. Translation: CAI20937.1 .
CH471067 Genomic DNA. Translation: EAW90950.1 .
BC126353 mRNA. Translation: AAI26354.1 .
BC126355 mRNA. Translation: AAI26356.1 .
CCDSi CCDS1309.1. [Q5TZF3-2 ]
RefSeqi NP_940895.1. NM_198493.2. [Q5TZF3-2 ]
UniGenei Hs.130054.

3D structure databases

ProteinModelPortali Q5TZF3.
SMRi Q5TZF3. Positions 51-178.
ModBasei Search...

Protein-protein interaction databases

BioGridi 130881. 1 interaction.
STRINGi 9606.ENSP00000331268.

Polymorphism databases

DMDMi 74756674.

Proteomic databases

MaxQBi Q5TZF3.
PaxDbi Q5TZF3.
PRIDEi Q5TZF3.

Protocols and materials databases

DNASUi 339416.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333279 ; ENSP00000331268 ; ENSG00000183831 . [Q5TZF3-2 ]
GeneIDi 339416.
KEGGi hsa:339416.
UCSCi uc001gja.1. human. [Q5TZF3-1 ]

Organism-specific databases

CTDi 339416.
GeneCardsi GC01M173577.
HGNCi HGNC:24786. ANKRD45.
HPAi HPA031655.
HPA031656.
HPA031657.
neXtProti NX_Q5TZF3.
PharmGKBi PA142672612.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292903.
HOGENOMi HOG000115657.
HOVERGENi HBG056753.
InParanoidi Q5TZF3.
OMAi RYSQTEC.
OrthoDBi EOG7K0ZD6.
PhylomeDBi Q5TZF3.
TreeFami TF329503.

Miscellaneous databases

GenomeRNAii 339416.
NextBioi 97390.
PROi Q5TZF3.

Gene expression databases

Bgeei Q5TZF3.
CleanExi HS_ANKRD45.
Genevestigatori Q5TZF3.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR029048. HSP70_C.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF100934. SSF100934. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Caudate nucleus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiANR45_HUMAN
AccessioniPrimary (citable) accession number: Q5TZF3
Secondary accession number(s): A1A4G2, Q6ZST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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