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Protein

Ankyrin repeat domain-containing protein 45

Gene

ANKRD45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 45
Gene namesi
Name:ANKRD45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183831.6.
HGNCiHGNC:24786. ANKRD45.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183831.
PharmGKBiPA142672612.

Polymorphism and mutation databases

BioMutaiANKRD45.
DMDMi74756674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445741 – 282Ankyrin repeat domain-containing protein 45Add BLAST282

Proteomic databases

EPDiQ5TZF3.
MaxQBiQ5TZF3.
PaxDbiQ5TZF3.
PeptideAtlasiQ5TZF3.
PRIDEiQ5TZF3.

PTM databases

iPTMnetiQ5TZF3.
PhosphoSitePlusiQ5TZF3.

Expressioni

Gene expression databases

BgeeiENSG00000183831.
CleanExiHS_ANKRD45.
GenevisibleiQ5TZF3. HS.

Organism-specific databases

HPAiHPA031655.
HPA031656.
HPA031657.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA2BQ96E033EBI-10247255,EBI-10239285

Protein-protein interaction databases

BioGridi130881. 2 interactors.
IntActiQ5TZF3. 3 interactors.
STRINGi9606.ENSP00000331268.

Structurei

3D structure databases

ProteinModelPortaliQ5TZF3.
SMRiQ5TZF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 121ANK 1Add BLAST30
Repeati125 – 154ANK 2Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 42Poly-Glu8

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0100. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000008829.
HOGENOMiHOG000115657.
HOVERGENiHBG056753.
InParanoidiQ5TZF3.
OMAiTPIFTKM.
OrthoDBiEOG091G0TUN.
PhylomeDBiQ5TZF3.
TreeFamiTF329503.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.20.1270.10. 1 hit.
1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR029048. HSP70_C.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 2 hits.
SUPFAMiSSF100934. SSF100934. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TZF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTEEAGARV WVFLELMESE GPPESESSEF FSQQEEENEE EEAQEPEETG
60 70 80 90 100
PKNPLLQPAL TGDVEGLQKI FEDPENPHHE QAMQLLLEED IVGRNLLYAA
110 120 130 140 150
CMAGQSDVIR ALAKYGVNLN EKTTRGYTLL HCAAAWGRLE TLKALVELDV
160 170 180 190 200
DIEALNFREE RARDVAARYS QTECVEFLDW ADARLTLKKY IAKVSLAVTD
210 220 230 240 250
TEKGSGKLLK EDKNTILSAC RAKNEWLETH TEASINELFE QRQQLEDIVT
260 270 280
PIFTKMTTPC QVKSAKSVTS HDQKRSQDDT SN
Length:282
Mass (Da):31,810
Last modified:December 7, 2004 - v1
Checksum:iA9FE7CF4C4D70967
GO
Isoform 2 (identifier: Q5TZF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Note: No experimental confirmation available.
Show »
Length:266
Mass (Da):29,977
Checksum:iB0ABDCB676455060
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196051 – 16Missing in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127170 mRNA. Translation: BAC86865.1.
BX248409, AL139142 Genomic DNA. Translation: CAH72999.1.
AL139142, BX248409 Genomic DNA. Translation: CAI20937.1.
CH471067 Genomic DNA. Translation: EAW90950.1.
BC126353 mRNA. Translation: AAI26354.1.
BC126355 mRNA. Translation: AAI26356.1.
CCDSiCCDS1309.1. [Q5TZF3-2]
RefSeqiNP_940895.1. NM_198493.2. [Q5TZF3-2]
XP_011507768.1. XM_011509466.2. [Q5TZF3-2]
XP_011507769.1. XM_011509467.1. [Q5TZF3-2]
XP_011507770.1. XM_011509468.1. [Q5TZF3-2]
XP_011507772.1. XM_011509470.1. [Q5TZF3-2]
UniGeneiHs.130054.

Genome annotation databases

EnsembliENST00000333279; ENSP00000331268; ENSG00000183831. [Q5TZF3-2]
GeneIDi339416.
KEGGihsa:339416.
UCSCiuc001gja.2. human. [Q5TZF3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANR45_HUMAN
AccessioniPrimary (citable) accession number: Q5TZF3
Secondary accession number(s): A1A4G2, Q6ZST1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: October 25, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM