Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5TZF3

- ANR45_HUMAN

UniProt

Q5TZF3 - ANR45_HUMAN

Protein

Ankyrin repeat domain-containing protein 45

Gene

ANKRD45

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 45
    Gene namesi
    Name:ANKRD45
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24786. ANKRD45.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672612.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Ankyrin repeat domain-containing protein 45PRO_0000244574Add
    BLAST

    Proteomic databases

    MaxQBiQ5TZF3.
    PaxDbiQ5TZF3.
    PRIDEiQ5TZF3.

    Expressioni

    Gene expression databases

    BgeeiQ5TZF3.
    CleanExiHS_ANKRD45.
    GenevestigatoriQ5TZF3.

    Organism-specific databases

    HPAiHPA031655.
    HPA031656.
    HPA031657.

    Interactioni

    Protein-protein interaction databases

    BioGridi130881. 1 interaction.
    STRINGi9606.ENSP00000331268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TZF3.
    SMRiQ5TZF3. Positions 51-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati92 – 12130ANK 1Add
    BLAST
    Repeati125 – 15430ANK 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 428Poly-Glu

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG292903.
    HOGENOMiHOG000115657.
    HOVERGENiHBG056753.
    InParanoidiQ5TZF3.
    OMAiRYSQTEC.
    OrthoDBiEOG7K0ZD6.
    PhylomeDBiQ5TZF3.
    TreeFamiTF329503.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR029048. HSP70_C.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF100934. SSF100934. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5TZF3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVTEEAGARV WVFLELMESE GPPESESSEF FSQQEEENEE EEAQEPEETG    50
    PKNPLLQPAL TGDVEGLQKI FEDPENPHHE QAMQLLLEED IVGRNLLYAA 100
    CMAGQSDVIR ALAKYGVNLN EKTTRGYTLL HCAAAWGRLE TLKALVELDV 150
    DIEALNFREE RARDVAARYS QTECVEFLDW ADARLTLKKY IAKVSLAVTD 200
    TEKGSGKLLK EDKNTILSAC RAKNEWLETH TEASINELFE QRQQLEDIVT 250
    PIFTKMTTPC QVKSAKSVTS HDQKRSQDDT SN 282
    Length:282
    Mass (Da):31,810
    Last modified:December 7, 2004 - v1
    Checksum:iA9FE7CF4C4D70967
    GO
    Isoform 2 (identifier: Q5TZF3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:266
    Mass (Da):29,977
    Checksum:iB0ABDCB676455060
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1616Missing in isoform 2. 2 PublicationsVSP_019605Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127170 mRNA. Translation: BAC86865.1.
    BX248409, AL139142 Genomic DNA. Translation: CAH72999.1.
    AL139142, BX248409 Genomic DNA. Translation: CAI20937.1.
    CH471067 Genomic DNA. Translation: EAW90950.1.
    BC126353 mRNA. Translation: AAI26354.1.
    BC126355 mRNA. Translation: AAI26356.1.
    CCDSiCCDS1309.1. [Q5TZF3-2]
    RefSeqiNP_940895.1. NM_198493.2. [Q5TZF3-2]
    UniGeneiHs.130054.

    Genome annotation databases

    EnsembliENST00000333279; ENSP00000331268; ENSG00000183831. [Q5TZF3-2]
    GeneIDi339416.
    KEGGihsa:339416.
    UCSCiuc001gja.1. human. [Q5TZF3-1]

    Polymorphism databases

    DMDMi74756674.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127170 mRNA. Translation: BAC86865.1 .
    BX248409 , AL139142 Genomic DNA. Translation: CAH72999.1 .
    AL139142 , BX248409 Genomic DNA. Translation: CAI20937.1 .
    CH471067 Genomic DNA. Translation: EAW90950.1 .
    BC126353 mRNA. Translation: AAI26354.1 .
    BC126355 mRNA. Translation: AAI26356.1 .
    CCDSi CCDS1309.1. [Q5TZF3-2 ]
    RefSeqi NP_940895.1. NM_198493.2. [Q5TZF3-2 ]
    UniGenei Hs.130054.

    3D structure databases

    ProteinModelPortali Q5TZF3.
    SMRi Q5TZF3. Positions 51-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130881. 1 interaction.
    STRINGi 9606.ENSP00000331268.

    Polymorphism databases

    DMDMi 74756674.

    Proteomic databases

    MaxQBi Q5TZF3.
    PaxDbi Q5TZF3.
    PRIDEi Q5TZF3.

    Protocols and materials databases

    DNASUi 339416.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333279 ; ENSP00000331268 ; ENSG00000183831 . [Q5TZF3-2 ]
    GeneIDi 339416.
    KEGGi hsa:339416.
    UCSCi uc001gja.1. human. [Q5TZF3-1 ]

    Organism-specific databases

    CTDi 339416.
    GeneCardsi GC01M173577.
    HGNCi HGNC:24786. ANKRD45.
    HPAi HPA031655.
    HPA031656.
    HPA031657.
    neXtProti NX_Q5TZF3.
    PharmGKBi PA142672612.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292903.
    HOGENOMi HOG000115657.
    HOVERGENi HBG056753.
    InParanoidi Q5TZF3.
    OMAi RYSQTEC.
    OrthoDBi EOG7K0ZD6.
    PhylomeDBi Q5TZF3.
    TreeFami TF329503.

    Miscellaneous databases

    GenomeRNAii 339416.
    NextBioi 97390.
    PROi Q5TZF3.

    Gene expression databases

    Bgeei Q5TZF3.
    CleanExi HS_ANKRD45.
    Genevestigatori Q5TZF3.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR029048. HSP70_C.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF100934. SSF100934. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Caudate nucleus.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.

    Entry informationi

    Entry nameiANR45_HUMAN
    AccessioniPrimary (citable) accession number: Q5TZF3
    Secondary accession number(s): A1A4G2, Q6ZST1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3