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Protein

Ankyrin repeat domain-containing protein 45

Gene

ANKRD45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 45
Gene namesi
Name:ANKRD45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24786. ANKRD45.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672612.

Polymorphism and mutation databases

BioMutaiANKRD45.
DMDMi74756674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Ankyrin repeat domain-containing protein 45PRO_0000244574Add
BLAST

Proteomic databases

MaxQBiQ5TZF3.
PaxDbiQ5TZF3.
PRIDEiQ5TZF3.

Expressioni

Gene expression databases

BgeeiQ5TZF3.
CleanExiHS_ANKRD45.
GenevisibleiQ5TZF3. HS.

Organism-specific databases

HPAiHPA031655.
HPA031656.
HPA031657.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA2BQ96E033EBI-10247255,EBI-10239285

Protein-protein interaction databases

BioGridi130881. 2 interactions.
IntActiQ5TZF3. 1 interaction.
STRINGi9606.ENSP00000331268.

Structurei

3D structure databases

ProteinModelPortaliQ5TZF3.
SMRiQ5TZF3. Positions 57-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati92 – 12130ANK 1Add
BLAST
Repeati125 – 15430ANK 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 428Poly-Glu

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG292903.
GeneTreeiENSGT00390000008829.
HOGENOMiHOG000115657.
HOVERGENiHBG056753.
InParanoidiQ5TZF3.
OMAiRYSQTEC.
OrthoDBiEOG7K0ZD6.
PhylomeDBiQ5TZF3.
TreeFamiTF329503.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR029048. HSP70_C.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF100934. SSF100934. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TZF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTEEAGARV WVFLELMESE GPPESESSEF FSQQEEENEE EEAQEPEETG
60 70 80 90 100
PKNPLLQPAL TGDVEGLQKI FEDPENPHHE QAMQLLLEED IVGRNLLYAA
110 120 130 140 150
CMAGQSDVIR ALAKYGVNLN EKTTRGYTLL HCAAAWGRLE TLKALVELDV
160 170 180 190 200
DIEALNFREE RARDVAARYS QTECVEFLDW ADARLTLKKY IAKVSLAVTD
210 220 230 240 250
TEKGSGKLLK EDKNTILSAC RAKNEWLETH TEASINELFE QRQQLEDIVT
260 270 280
PIFTKMTTPC QVKSAKSVTS HDQKRSQDDT SN
Length:282
Mass (Da):31,810
Last modified:December 7, 2004 - v1
Checksum:iA9FE7CF4C4D70967
GO
Isoform 2 (identifier: Q5TZF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Note: No experimental confirmation available.
Show »
Length:266
Mass (Da):29,977
Checksum:iB0ABDCB676455060
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616Missing in isoform 2. 2 PublicationsVSP_019605Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127170 mRNA. Translation: BAC86865.1.
BX248409, AL139142 Genomic DNA. Translation: CAH72999.1.
AL139142, BX248409 Genomic DNA. Translation: CAI20937.1.
CH471067 Genomic DNA. Translation: EAW90950.1.
BC126353 mRNA. Translation: AAI26354.1.
BC126355 mRNA. Translation: AAI26356.1.
CCDSiCCDS1309.1. [Q5TZF3-2]
RefSeqiNP_940895.1. NM_198493.2. [Q5TZF3-2]
UniGeneiHs.130054.

Genome annotation databases

EnsembliENST00000333279; ENSP00000331268; ENSG00000183831. [Q5TZF3-2]
GeneIDi339416.
KEGGihsa:339416.
UCSCiuc001gja.1. human. [Q5TZF3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127170 mRNA. Translation: BAC86865.1.
BX248409, AL139142 Genomic DNA. Translation: CAH72999.1.
AL139142, BX248409 Genomic DNA. Translation: CAI20937.1.
CH471067 Genomic DNA. Translation: EAW90950.1.
BC126353 mRNA. Translation: AAI26354.1.
BC126355 mRNA. Translation: AAI26356.1.
CCDSiCCDS1309.1. [Q5TZF3-2]
RefSeqiNP_940895.1. NM_198493.2. [Q5TZF3-2]
UniGeneiHs.130054.

3D structure databases

ProteinModelPortaliQ5TZF3.
SMRiQ5TZF3. Positions 57-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130881. 2 interactions.
IntActiQ5TZF3. 1 interaction.
STRINGi9606.ENSP00000331268.

Polymorphism and mutation databases

BioMutaiANKRD45.
DMDMi74756674.

Proteomic databases

MaxQBiQ5TZF3.
PaxDbiQ5TZF3.
PRIDEiQ5TZF3.

Protocols and materials databases

DNASUi339416.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333279; ENSP00000331268; ENSG00000183831. [Q5TZF3-2]
GeneIDi339416.
KEGGihsa:339416.
UCSCiuc001gja.1. human. [Q5TZF3-1]

Organism-specific databases

CTDi339416.
GeneCardsiGC01M173577.
HGNCiHGNC:24786. ANKRD45.
HPAiHPA031655.
HPA031656.
HPA031657.
neXtProtiNX_Q5TZF3.
PharmGKBiPA142672612.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG292903.
GeneTreeiENSGT00390000008829.
HOGENOMiHOG000115657.
HOVERGENiHBG056753.
InParanoidiQ5TZF3.
OMAiRYSQTEC.
OrthoDBiEOG7K0ZD6.
PhylomeDBiQ5TZF3.
TreeFamiTF329503.

Miscellaneous databases

GenomeRNAii339416.
NextBioi97390.
PROiQ5TZF3.

Gene expression databases

BgeeiQ5TZF3.
CleanExiHS_ANKRD45.
GenevisibleiQ5TZF3. HS.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR029048. HSP70_C.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF100934. SSF100934. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Caudate nucleus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiANR45_HUMAN
AccessioniPrimary (citable) accession number: Q5TZF3
Secondary accession number(s): A1A4G2, Q6ZST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.