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Q5TZA2

- CROCC_HUMAN

UniProt

Q5TZA2 - CROCC_HUMAN

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Protein

Rootletin

Gene

CROCC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.By similarity1 Publication

GO - Molecular functioni

  1. kinesin binding Source: UniProtKB
  2. structural molecule activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell projection organization Source: UniProtKB-KW
  3. centriole-centriole cohesion Source: UniProtKB
  4. centrosome organization Source: UniProtKB
  5. protein localization Source: UniProtKB
  6. protein localization to organelle Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Rootletin
Alternative name(s):
Ciliary rootlet coiled-coil protein
Gene namesi
Name:CROCCImported
Synonyms:KIAA0445Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:21299. CROCC.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 1 Publication
Note: In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. centriole Source: UniProtKB
  3. centrosome Source: UniProtKB
  4. ciliary rootlet Source: UniProtKB
  5. cytoplasm Source: HPA
  6. extracellular vesicular exosome Source: UniProt
  7. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20172017RootletinPRO_0000239943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1460 – 14601Phosphoserine1 Publication
Modified residuei1660 – 16601Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by NEK2 which may regulate its association with centrosomes.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5TZA2.
PaxDbiQ5TZA2.
PRIDEiQ5TZA2.

PTM databases

PhosphoSiteiQ5TZA2.

Expressioni

Gene expression databases

BgeeiQ5TZA2.
CleanExiHS_CROCC.
GenevestigatoriQ5TZA2.

Organism-specific databases

HPAiHPA021191.
HPA021762.

Interactioni

Subunit structurei

Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.1 Publication

Protein-protein interaction databases

BioGridi115048. 7 interactions.
IntActiQ5TZA2. 4 interactions.
MINTiMINT-2807877.
STRINGi9606.ENSP00000364691.

Structurei

3D structure databases

ProteinModelPortaliQ5TZA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 262193Sequence AnalysisAdd
BLAST
Coiled coili318 – 444127Sequence AnalysisAdd
BLAST
Coiled coili546 – 1058513Sequence AnalysisAdd
BLAST
Coiled coili1091 – 1438348Sequence AnalysisAdd
BLAST
Coiled coili1505 – 1704200Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1921 – 199979Gln-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the rootletin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000110800.
HOGENOMiHOG000231187.
HOVERGENiHBG080162.
InParanoidiQ5TZA2.
OMAiYKKRCSE.
OrthoDBiEOG7W6WJX.
PhylomeDBiQ5TZA2.
TreeFamiTF101138.

Family and domain databases

InterProiIPR026733. Rootletin.
[Graphical view]
PANTHERiPTHR23159:SF11. PTHR23159:SF11. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q5TZA2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLGLARAQE VELTLETVIQ TLESSVLCQE KGLGARDLAQ DAQITSLPAL
60 70 80 90 100
IREIVTRNLS QPESPVLLPA TEMASLLSLQ EENQLLQQEL SRVEDLLAQS
110 120 130 140 150
RAERDELAIK YNAVSERLEQ ALRLEPGELE TQEPRGLVRQ SVELRRQLQE
160 170 180 190 200
EQASYRRKLQ AYQEGQQRQA QLVQRLQGKI LQYKKRCSEL EQQLLERSGE
210 220 230 240 250
LEQQRLRDTE HSQDLESALI RLEEEQQRSA SLAQVNAMLR EQLDQAGSAN
260 270 280 290 300
QALSEDIRKV TNDWTRCRKE LEHREAAWRR EEESFNAYFS NEHSRLLLLW
310 320 330 340 350
RQVVGFRRLV SEVKMFTERD LLQLGGELAR TSRAVQEAGL GLSTGLRLAE
360 370 380 390 400
SRAEAALEKQ ALLQAQLEEQ LRDKVLREKD LAQQQMQSDL DKADLSARVT
410 420 430 440 450
ELGLAVKRLE KQNLEKDQVN KDLTEKLEAL ESLRLQEQAA LETEDGEGLQ
460 470 480 490 500
QTLRDLAQAV LSDSESGVQL SGSERTADAS NGSLRGLSGQ RTPSPPRRSS
510 520 530 540 550
PGRGRSPRRG PSPACSDSST LALIHSALHK RQLQVQDMRG RYEASQDLLG
560 570 580 590 600
TLRKQLSDSE SERRALEEQL QRLRDKTDGA MQAHEDAQRE VQRLRSANEL
610 620 630 640 650
LSREKSNLAH SLQVAQQQAE ELRQEREKLQ AAQEELRRQR DRLEEEQEDA
660 670 680 690 700
VQDGARVRRE LERSHRQLEQ LEGKRSVLAK ELVEVREALS RATLQRDMLQ
710 720 730 740 750
AEKAEVAEAL TKAEAGRVEL ELSMTKLRAE EASLQDSLSK LSALNESLAQ
760 770 780 790 800
DKLDLNRLVA QLEEEKSALQ GRQRQAEQEA TVAREEQERL EELRLEQEVA
810 820 830 840 850
RQGLEGSLRV AEQAQEALEQ QLPTLRHERS QLQEQLAQLS RQLSGREQEL
860 870 880 890 900
EQARREAQRQ VEALERAARE KEALAKEHAG LAVQLVAAER EGRTLSEEAT
910 920 930 940 950
RLRLEKEALE GSLFEVQRQL AQLEARREQL EAEGQALLLA KETLTGELAG
960 970 980 990 1000
LRQQIIATQE KASLDKELMA QKLVQAEREA QASLREQRAA HEEDLQRLQR
1010 1020 1030 1040 1050
EKEAAWRELE AERAQLQSQL QREQEELLAR LEAEKEELSE EIAALQQERD
1060 1070 1080 1090 1100
EGLLLAESEK QQALSLKESE KTALSEKLMG TRHSLATISL EMERQKRDAQ
1110 1120 1130 1140 1150
SRQEQDRSTV NALTSELRDL RAQREEAAAA HAQEVRRLQE QARDLGKQRD
1160 1170 1180 1190 1200
SCLREAEELR TQLRLLEDAR DGLRRELLEA QRKLRESQEG REVQRQEAGE
1210 1220 1230 1240 1250
LRRSLGEGAK EREALRRSNE ELRSAVKKAE SERISLKLAN EDKEQKLALL
1260 1270 1280 1290 1300
EEARTAVGKE AGELRTGLQE VERSRLEARR ELQELRRQMK MLDSENTRLG
1310 1320 1330 1340 1350
RELAELQGRL ALGERAEKES RRETLGLRQR LLKGEASLEV MRQELQVAQR
1360 1370 1380 1390 1400
KLQEQEGEFR TRERRLLGSL EEARGTEKQQ LDHARGLELK LEAARAEAAE
1410 1420 1430 1440 1450
LGLRLSAAEG RAQGLEAELA RVEVQRRAAE AQLGGLRSAL RRGLGLGRAP
1460 1470 1480 1490 1500
SPAPRPVPGS PARDAPAEGS GEGLNSPSTL ECSPGSQPPS PGPATSPASP
1510 1520 1530 1540 1550
DLDPEAVRGA LREFLQELRS AQRERDELRT QTSALNRQLA EMEAERDSAT
1560 1570 1580 1590 1600
SRARQLQKAV AESEEARRSV DGRLSGVQAE LALQEESVRR SERERRATLD
1610 1620 1630 1640 1650
QVATLERSLQ ATESELRASQ EKISKMKANE TKLEGDKRRL KEVLDASESR
1660 1670 1680 1690 1700
TVKLELQRRS LEGELQRSRL GLSDREAQAQ ALQDRVDSLQ RQVADSEVKA
1710 1720 1730 1740 1750
GTLQLTVERL NGALAKVEES EGALRDKVRG LTEALAQSSA SLNSTRDKNL
1760 1770 1780 1790 1800
HLQKALTACE HDRQVLQERL DAARQALSEA RKQSSSLGEQ VQTLRGEVAD
1810 1820 1830 1840 1850
LELQRVEAEG QLQQLREVLR QRQEGEAAAL NTVQKLQDER RLLQERLGSL
1860 1870 1880 1890 1900
QRALAQLEAE KREVERSALR LEKDRVALRR TLDKVEREKL RSHEDTVRLS
1910 1920 1930 1940 1950
AEKGRLDRTL TGAELELAEA QRQIQQLEAQ VVVLEQSHSP AQLEVDAQQQ
1960 1970 1980 1990 2000
QLELQQEVER LRSAQAQTER TLEARERAHR QRVRGLEEQV STLKGQLQQE
2010
LRRSSAPFSP PSGPPEK
Length:2,017
Mass (Da):228,523
Last modified:December 7, 2004 - v1
Checksum:i9711AC13AD9D7C07
GO
Isoform 21 Publication (identifier: Q5TZA2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-697: Missing.
     1984-1990: Missing.

Show »
Length:1,313
Mass (Da):148,256
Checksum:i00DC42FDE419EED1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → G.
Corresponds to variant rs6586566 [ dbSNP | Ensembl ].
VAR_061626
Natural varianti372 – 3721R → Q.
Corresponds to variant rs57442576 [ dbSNP | Ensembl ].
VAR_061627
Natural varianti439 – 4391A → V.
Corresponds to variant rs4463721 [ dbSNP | Ensembl ].
VAR_059628
Natural varianti586 – 5861D → H.
Corresponds to variant rs9435714 [ dbSNP | Ensembl ].
VAR_059629
Natural varianti1097 – 10971R → P.
Corresponds to variant rs6669627 [ dbSNP | Ensembl ].
VAR_059630

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 697697Missing in isoform 2. 2 PublicationsVSP_052069Add
BLAST
Alternative sequencei1984 – 19907Missing in isoform 2. 2 PublicationsVSP_052070

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ139275 mRNA. Translation: ABA43896.1.
BX284668, AL049569 Genomic DNA. Translation: CAH70055.1.
AL049569, BX284668 Genomic DNA. Translation: CAI20363.1.
AB007914 mRNA. Translation: BAA32290.2.
AF527734 mRNA. Translation: AAP85633.1.
BK005505 mRNA. Translation: DAA05505.1.
CCDSiCCDS30616.1. [Q5TZA2-1]
RefSeqiNP_055490.4. NM_014675.4.
UniGeneiHs.309403.

Genome annotation databases

EnsembliENST00000375541; ENSP00000364691; ENSG00000058453.
GeneIDi9696.
UCSCiuc001azt.2. human. [Q5TZA2-1]
uc001azu.2. human. [Q5TZA2-2]

Polymorphism databases

DMDMi74746681.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ139275 mRNA. Translation: ABA43896.1 .
BX284668 , AL049569 Genomic DNA. Translation: CAH70055.1 .
AL049569 , BX284668 Genomic DNA. Translation: CAI20363.1 .
AB007914 mRNA. Translation: BAA32290.2 .
AF527734 mRNA. Translation: AAP85633.1 .
BK005505 mRNA. Translation: DAA05505.1 .
CCDSi CCDS30616.1. [Q5TZA2-1 ]
RefSeqi NP_055490.4. NM_014675.4.
UniGenei Hs.309403.

3D structure databases

ProteinModelPortali Q5TZA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115048. 7 interactions.
IntActi Q5TZA2. 4 interactions.
MINTi MINT-2807877.
STRINGi 9606.ENSP00000364691.

PTM databases

PhosphoSitei Q5TZA2.

Polymorphism databases

DMDMi 74746681.

Proteomic databases

MaxQBi Q5TZA2.
PaxDbi Q5TZA2.
PRIDEi Q5TZA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375541 ; ENSP00000364691 ; ENSG00000058453 .
GeneIDi 9696.
UCSCi uc001azt.2. human. [Q5TZA2-1 ]
uc001azu.2. human. [Q5TZA2-2 ]

Organism-specific databases

CTDi 9696.
GeneCardsi GC01P017099.
H-InvDB HIX0000171.
HIX0000176.
HGNCi HGNC:21299. CROCC.
HPAi HPA021191.
HPA021762.
MIMi 615776. gene.
neXtProti NX_Q5TZA2.
PharmGKBi PA134911945.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000110800.
HOGENOMi HOG000231187.
HOVERGENi HBG080162.
InParanoidi Q5TZA2.
OMAi YKKRCSE.
OrthoDBi EOG7W6WJX.
PhylomeDBi Q5TZA2.
TreeFami TF101138.

Miscellaneous databases

ChiTaRSi CROCC. human.
GeneWikii Rootletin.
GenomeRNAii 9696.
NextBioi 36431.
PROi Q5TZA2.
SOURCEi Search...

Gene expression databases

Bgeei Q5TZA2.
CleanExi HS_CROCC.
Genevestigatori Q5TZA2.

Family and domain databases

InterProi IPR026733. Rootletin.
[Graphical view ]
PANTHERi PTHR23159:SF11. PTHR23159:SF11. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A centrosomal target of human T-cell leukemia virus type 1 oncoprotein Tax."
    Ching Y.-P., Chan S.-F., Jeang K.-T., Jin D.-Y.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-2017 (ISOFORM 1).
    Tissue: BrainImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1572-2017 (ISOFORM 2).
    Tissue: MedulloblastomaImported.
  5. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  6. "Rootletin forms centriole-associated filaments and functions in centrosome cohesion."
    Bahe S., Stierhof Y.-D., Wilkinson C.J., Leiss F., Nigg E.A.
    J. Cell Biol. 171:27-33(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CEP250 AND NEK2, PHOSPHORYLATION.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1460 AND SER-1660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCROCC_HUMAN
AccessioniPrimary (citable) accession number: Q5TZA2
Secondary accession number(s): Q2VHY3
, Q66GT7, Q7Z2L4, Q7Z5D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3