SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5TZA2

- CROCC_HUMAN

UniProt

Q5TZA2 - CROCC_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Rootletin

Gene
CROCC, KIAA0445
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.By similarity1 Publication

GO - Molecular functioni

  1. kinesin binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. structural molecule activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell projection organization Source: UniProtKB-KW
  3. centrosome organization Source: UniProtKB
  4. protein localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Rootletin
Alternative name(s):
Ciliary rootlet coiled-coil protein
Gene namesi
Name:CROCC
Synonyms:KIAA0445
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:21299. CROCC.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole
Note: In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.1 Publication

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. centriole Source: UniProtKB
  3. centrosome Source: UniProtKB
  4. ciliary rootlet Source: UniProtKB
  5. cytoplasm Source: HPA
  6. extracellular vesicular exosome Source: UniProt
  7. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20172017RootletinPRO_0000239943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1460 – 14601Phosphoserine1 Publication
Modified residuei1660 – 16601Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by NEK2 which may regulate its association with centrosomes.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5TZA2.
PaxDbiQ5TZA2.
PRIDEiQ5TZA2.

PTM databases

PhosphoSiteiQ5TZA2.

Expressioni

Gene expression databases

BgeeiQ5TZA2.
CleanExiHS_CROCC.
GenevestigatoriQ5TZA2.

Organism-specific databases

HPAiHPA021191.
HPA021762.

Interactioni

Subunit structurei

Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.By similarity1 Publication

Protein-protein interaction databases

BioGridi115048. 4 interactions.
IntActiQ5TZA2. 4 interactions.
MINTiMINT-2807877.
STRINGi9606.ENSP00000364691.

Structurei

3D structure databases

ProteinModelPortaliQ5TZA2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 262193 Reviewed predictionAdd
BLAST
Coiled coili318 – 444127 Reviewed predictionAdd
BLAST
Coiled coili546 – 1058513 Reviewed predictionAdd
BLAST
Coiled coili1091 – 1438348 Reviewed predictionAdd
BLAST
Coiled coili1505 – 1704200 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1921 – 199979Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the rootletin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000231187.
HOVERGENiHBG080162.
InParanoidiQ5TZA2.
KOiK16469.
OMAiYKKRCSE.
OrthoDBiEOG7W6WJX.
PhylomeDBiQ5TZA2.
TreeFamiTF101138.

Family and domain databases

InterProiIPR026733. Rootletin.
[Graphical view]
PANTHERiPTHR23159:SF11. PTHR23159:SF11. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q5TZA2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLGLARAQE VELTLETVIQ TLESSVLCQE KGLGARDLAQ DAQITSLPAL     50
IREIVTRNLS QPESPVLLPA TEMASLLSLQ EENQLLQQEL SRVEDLLAQS 100
RAERDELAIK YNAVSERLEQ ALRLEPGELE TQEPRGLVRQ SVELRRQLQE 150
EQASYRRKLQ AYQEGQQRQA QLVQRLQGKI LQYKKRCSEL EQQLLERSGE 200
LEQQRLRDTE HSQDLESALI RLEEEQQRSA SLAQVNAMLR EQLDQAGSAN 250
QALSEDIRKV TNDWTRCRKE LEHREAAWRR EEESFNAYFS NEHSRLLLLW 300
RQVVGFRRLV SEVKMFTERD LLQLGGELAR TSRAVQEAGL GLSTGLRLAE 350
SRAEAALEKQ ALLQAQLEEQ LRDKVLREKD LAQQQMQSDL DKADLSARVT 400
ELGLAVKRLE KQNLEKDQVN KDLTEKLEAL ESLRLQEQAA LETEDGEGLQ 450
QTLRDLAQAV LSDSESGVQL SGSERTADAS NGSLRGLSGQ RTPSPPRRSS 500
PGRGRSPRRG PSPACSDSST LALIHSALHK RQLQVQDMRG RYEASQDLLG 550
TLRKQLSDSE SERRALEEQL QRLRDKTDGA MQAHEDAQRE VQRLRSANEL 600
LSREKSNLAH SLQVAQQQAE ELRQEREKLQ AAQEELRRQR DRLEEEQEDA 650
VQDGARVRRE LERSHRQLEQ LEGKRSVLAK ELVEVREALS RATLQRDMLQ 700
AEKAEVAEAL TKAEAGRVEL ELSMTKLRAE EASLQDSLSK LSALNESLAQ 750
DKLDLNRLVA QLEEEKSALQ GRQRQAEQEA TVAREEQERL EELRLEQEVA 800
RQGLEGSLRV AEQAQEALEQ QLPTLRHERS QLQEQLAQLS RQLSGREQEL 850
EQARREAQRQ VEALERAARE KEALAKEHAG LAVQLVAAER EGRTLSEEAT 900
RLRLEKEALE GSLFEVQRQL AQLEARREQL EAEGQALLLA KETLTGELAG 950
LRQQIIATQE KASLDKELMA QKLVQAEREA QASLREQRAA HEEDLQRLQR 1000
EKEAAWRELE AERAQLQSQL QREQEELLAR LEAEKEELSE EIAALQQERD 1050
EGLLLAESEK QQALSLKESE KTALSEKLMG TRHSLATISL EMERQKRDAQ 1100
SRQEQDRSTV NALTSELRDL RAQREEAAAA HAQEVRRLQE QARDLGKQRD 1150
SCLREAEELR TQLRLLEDAR DGLRRELLEA QRKLRESQEG REVQRQEAGE 1200
LRRSLGEGAK EREALRRSNE ELRSAVKKAE SERISLKLAN EDKEQKLALL 1250
EEARTAVGKE AGELRTGLQE VERSRLEARR ELQELRRQMK MLDSENTRLG 1300
RELAELQGRL ALGERAEKES RRETLGLRQR LLKGEASLEV MRQELQVAQR 1350
KLQEQEGEFR TRERRLLGSL EEARGTEKQQ LDHARGLELK LEAARAEAAE 1400
LGLRLSAAEG RAQGLEAELA RVEVQRRAAE AQLGGLRSAL RRGLGLGRAP 1450
SPAPRPVPGS PARDAPAEGS GEGLNSPSTL ECSPGSQPPS PGPATSPASP 1500
DLDPEAVRGA LREFLQELRS AQRERDELRT QTSALNRQLA EMEAERDSAT 1550
SRARQLQKAV AESEEARRSV DGRLSGVQAE LALQEESVRR SERERRATLD 1600
QVATLERSLQ ATESELRASQ EKISKMKANE TKLEGDKRRL KEVLDASESR 1650
TVKLELQRRS LEGELQRSRL GLSDREAQAQ ALQDRVDSLQ RQVADSEVKA 1700
GTLQLTVERL NGALAKVEES EGALRDKVRG LTEALAQSSA SLNSTRDKNL 1750
HLQKALTACE HDRQVLQERL DAARQALSEA RKQSSSLGEQ VQTLRGEVAD 1800
LELQRVEAEG QLQQLREVLR QRQEGEAAAL NTVQKLQDER RLLQERLGSL 1850
QRALAQLEAE KREVERSALR LEKDRVALRR TLDKVEREKL RSHEDTVRLS 1900
AEKGRLDRTL TGAELELAEA QRQIQQLEAQ VVVLEQSHSP AQLEVDAQQQ 1950
QLELQQEVER LRSAQAQTER TLEARERAHR QRVRGLEEQV STLKGQLQQE 2000
LRRSSAPFSP PSGPPEK 2017
Length:2,017
Mass (Da):228,523
Last modified:December 7, 2004 - v1
Checksum:i9711AC13AD9D7C07
GO
Isoform 21 Publication (identifier: Q5TZA2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-697: Missing.
     1984-1990: Missing.

Show »
Length:1,313
Mass (Da):148,256
Checksum:i00DC42FDE419EED1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → G.
Corresponds to variant rs6586566 [ dbSNP | Ensembl ].
VAR_061626
Natural varianti372 – 3721R → Q.
Corresponds to variant rs57442576 [ dbSNP | Ensembl ].
VAR_061627
Natural varianti439 – 4391A → V.
Corresponds to variant rs4463721 [ dbSNP | Ensembl ].
VAR_059628
Natural varianti586 – 5861D → H.
Corresponds to variant rs9435714 [ dbSNP | Ensembl ].
VAR_059629
Natural varianti1097 – 10971R → P.
Corresponds to variant rs6669627 [ dbSNP | Ensembl ].
VAR_059630

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 697697Missing in isoform 2. 1 PublicationVSP_052069Add
BLAST
Alternative sequencei1984 – 19907Missing in isoform 2. 1 PublicationVSP_052070

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ139275 mRNA. Translation: ABA43896.1.
BX284668, AL049569 Genomic DNA. Translation: CAH70055.1.
AL049569, BX284668 Genomic DNA. Translation: CAI20363.1.
AB007914 mRNA. Translation: BAA32290.2.
AF527734 mRNA. Translation: AAP85633.1.
BK005505 mRNA. Translation: DAA05505.1.
CCDSiCCDS30616.1. [Q5TZA2-1]
RefSeqiNP_055490.4. NM_014675.4.
UniGeneiHs.309403.

Genome annotation databases

EnsembliENST00000375541; ENSP00000364691; ENSG00000058453. [Q5TZA2-1]
GeneIDi9696.
KEGGihsa:9696.
UCSCiuc001azt.2. human. [Q5TZA2-1]
uc001azu.2. human. [Q5TZA2-2]

Polymorphism databases

DMDMi74746681.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ139275 mRNA. Translation: ABA43896.1 .
BX284668 , AL049569 Genomic DNA. Translation: CAH70055.1 .
AL049569 , BX284668 Genomic DNA. Translation: CAI20363.1 .
AB007914 mRNA. Translation: BAA32290.2 .
AF527734 mRNA. Translation: AAP85633.1 .
BK005505 mRNA. Translation: DAA05505.1 .
CCDSi CCDS30616.1. [Q5TZA2-1 ]
RefSeqi NP_055490.4. NM_014675.4.
UniGenei Hs.309403.

3D structure databases

ProteinModelPortali Q5TZA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115048. 4 interactions.
IntActi Q5TZA2. 4 interactions.
MINTi MINT-2807877.
STRINGi 9606.ENSP00000364691.

PTM databases

PhosphoSitei Q5TZA2.

Polymorphism databases

DMDMi 74746681.

Proteomic databases

MaxQBi Q5TZA2.
PaxDbi Q5TZA2.
PRIDEi Q5TZA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375541 ; ENSP00000364691 ; ENSG00000058453 . [Q5TZA2-1 ]
GeneIDi 9696.
KEGGi hsa:9696.
UCSCi uc001azt.2. human. [Q5TZA2-1 ]
uc001azu.2. human. [Q5TZA2-2 ]

Organism-specific databases

CTDi 9696.
GeneCardsi GC01P017093.
H-InvDB HIX0000171.
HIX0000176.
HGNCi HGNC:21299. CROCC.
HPAi HPA021191.
HPA021762.
MIMi 615776. gene.
neXtProti NX_Q5TZA2.
PharmGKBi PA134911945.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000231187.
HOVERGENi HBG080162.
InParanoidi Q5TZA2.
KOi K16469.
OMAi YKKRCSE.
OrthoDBi EOG7W6WJX.
PhylomeDBi Q5TZA2.
TreeFami TF101138.

Miscellaneous databases

ChiTaRSi CROCC. human.
GeneWikii Rootletin.
GenomeRNAii 9696.
NextBioi 36431.
PROi Q5TZA2.
SOURCEi Search...

Gene expression databases

Bgeei Q5TZA2.
CleanExi HS_CROCC.
Genevestigatori Q5TZA2.

Family and domain databases

InterProi IPR026733. Rootletin.
[Graphical view ]
PANTHERi PTHR23159:SF11. PTHR23159:SF11. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A centrosomal target of human T-cell leukemia virus type 1 oncoprotein Tax."
    Ching Y.-P., Chan S.-F., Jeang K.-T., Jin D.-Y.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-2017 (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1572-2017 (ISOFORM 2).
    Tissue: Medulloblastoma.
  5. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  6. "Rootletin forms centriole-associated filaments and functions in centrosome cohesion."
    Bahe S., Stierhof Y.-D., Wilkinson C.J., Leiss F., Nigg E.A.
    J. Cell Biol. 171:27-33(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CEP250 AND NEK2, PHOSPHORYLATION.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1460 AND SER-1660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCROCC_HUMAN
AccessioniPrimary (citable) accession number: Q5TZA2
Secondary accession number(s): Q2VHY3
, Q66GT7, Q7Z2L4, Q7Z5D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi