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Protein
Submitted name:

BRF1, RNA polymerase III transcription initiation factor b

Gene

brf1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 32TFIIB-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

  • cerebellum development Source: ZFIN
  • DNA-templated transcriptional preinitiation complex assembly Source: InterPro
  • thrombocyte differentiation Source: ZFIN
  • transcription from RNA polymerase III promoter Source: InterPro

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-DRE-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Submitted name:
BRF1, RNA polymerase III transcription initiation factor bImported
Gene namesi
Name:brf1bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030131-6248. brf1b.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ5TZ89.

Expressioni

Gene expression databases

BgeeiENSDARG00000005002.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000038308.

Structurei

3D structure databases

ProteinModelPortaliQ5TZ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 32TFIIB-typeInterPro annotationAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili295 – 333Sequence analysisAdd BLAST39

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 32TFIIB-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1598. Eukaryota.
COG1405. LUCA.
GeneTreeiENSGT00390000010349.
HOGENOMiHOG000198688.
HOVERGENiHBG023540.
InParanoidiQ5TZ89.
OMAiHDPPSFY.
OrthoDBiEOG091G0Q88.
TreeFamiTF324046.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR029529. Brf1.
IPR011665. BRF1_TBP-bd_dom.
IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
PANTHERiPTHR11618. PTHR11618. 1 hit.
PTHR11618:SF36. PTHR11618:SF36. 1 hit.
PfamiView protein in Pfam
PF07741. BRF1. 1 hit.
PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
PRINTSiPR00685. TIFACTORIIB.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS51134. ZF_TFIIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TZ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQCKNCGG SDIDTDPARG SAVCTACGSV LEDNIIVSEV QFVENSGGVS
60 70 80 90 100
SAVGQFVSAD GTSKAPVLGS GFHTSLGKES RAQTLQNGKR QIHNLGSQLQ
110 120 130 140 150
LNQHCLDTAF NFFKMVVSKH LTRGRKMTHV IAACLYLVCR TEGTPHMLLD
160 170 180 190 200
LSDLLQVNVY ILGKTFLLLA RELCINAPAV DPCLYIPRFA HMLEFGEKTH
210 220 230 240 250
EVSMTALRLL QRMKRDWMHT GRRPSGLCGA ALLVAARMHE FRRTVKEVIS
260 270 280 290 300
VVKVCEATLR KRLTEFEETP TSSLTIDEFM RVDLEKECDP PSFVAGQKKV
310 320 330 340 350
KMQQLEQELV KKLEEYQGEI DSYRDEIETQ LAGSSRTKMK GIYASYARED
360 370 380 390 400
DDSLSLASGL AGDEDAEDEE MEAAAKHLNQ EFISQVLNRR DQGGKKDLDG
410 420 430 440 450
RKNTVPLPNQ SKHVPLTALL GPLPSAASLG LTDSIRQCIT ETTNVEEKSD
460 470 480 490 500
SGELDLDGID EDEIEKYILN EIEVEAKTEL WMKQNEEYLR EQKEKEERIA
510 520 530 540 550
KEKEQGTYKE KPKKPSKKRE PILASTAGEA IEKMLEQKKI SSKINYDVLR
560 570 580 590 600
DLNSKGSASS STQQAEDVPT SGSGRKRLTR RKKQPNKSNL GLAKPASLMG
610 620 630 640 650
KRLRPLISSV PKKMRTAAAL FTPSMTMMLP PAAPEPPPAP TPPPVLESGP
660 670 680 690
VAYDEPAEEE EEIEEEAEES CVSAMELIGG NEYGCEAEEE EVF
Length:693
Mass (Da):76,757
Last modified:December 7, 2004 - v1
Checksum:i5FAAF218348D3638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255905 Genomic DNA. No translation available.
BX296516 Genomic DNA. No translation available.
BX530065 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSDART00000035827; ENSDARP00000038308; ENSDARG00000005002.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ5TZ89_DANRE
AccessioniPrimary (citable) accession number: Q5TZ89
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported