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UniProtKB - Q5TZ42 (Q5TZ42_DANRE)

UniProt

Q5TZ42 - Q5TZ42_DANRE

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Protein
Submitted name:

CDC42 binding protein kinase beta (DMPK-like)

Gene

cdc42bpb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
CDC42 binding protein kinase beta (DMPK-like)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:cdc42bpbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030131-3647. cdc42bpb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSDARG00000019383.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000049436.

Structurei

3D structure databases

SMRiQ5TZ42. Positions 37-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 342267Protein kinaseInterPro annotationAdd
BLAST
Domaini343 – 41371AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini1021 – 107151Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini1091 – 1210120PHInterPro annotationAdd
BLAST
Domaini1236 – 1509274CNHInterPro annotationAdd
BLAST
Domaini1580 – 159314CRIBInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili436 – 46328Sequence analysisAdd
BLAST
Coiled coili483 – 51028Sequence analysisAdd
BLAST
Coiled coili517 – 642126Sequence analysisAdd
BLAST
Coiled coili695 – 77682Sequence analysisAdd
BLAST
Coiled coili784 – 81431Sequence analysisAdd
BLAST
Coiled coili901 – 93535Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.SAAS annotation
Contains AGC-kinase C-terminal domain.SAAS annotation
Contains PH domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410IT51. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000294133.
HOVERGENiHBG055933.
KOiK16307.
OMAiSCFSDRG.
OrthoDBiEOG091G09EX.
PhylomeDBiQ5TZ42.
TreeFamiTF313551.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR001180. CNH_dom.
IPR000095. CRIB_dom.
IPR031597. KELK.
IPR011009. Kinase-like_dom.
IPR014930. Myotonic_dystrophy_kinase_coil.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00780. CNH. 1 hit.
PF08826. DMPK_coil. 1 hit.
PF15796. KELK. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
ProDomiPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00285. PBD. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50108. CRIB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TZ42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKVRLKKL EQLLLDGHQK NDKSLSVETL LDILICLYNE CSNSPLKREK 
        60         70         80         90        100
HVTDFLEWVK PFTTTVKEMR LHRDDFEMLK VIGRGAFGEV AVVKMKHTER 
       110        120        130        140        150
VYAMKILNKW EMLKRAETAC FREERNVLVN GDCQWITTLH YAFQDDNYLY 
       160        170        180        190        200
LVMDYYVGGD LLTLLSKFED RLPEDMAKFY VAEMVLAIHS IHQQRYVHRD 
       210        220        230        240        250
IKPDNVLLDM NGHIRLADFG SCLKMMQDGT VQSSVAVGTP DYISPEILQA 
       260        270        280        290        300
MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 
       310        320        330        340        350
QFPSHITDVS EDAKDLIQRL ICSRERRLGQ HGIEEFRKHA FFSGIDWENI 
       360        370        380        390        400
RNMEAPYIPD VSSPSDTSNF DVDDDVLKNP DIAPPVSHTG FTGQHLPFVG 
       410        420        430        440        450
FTYTTESCFS DGGSMRGVAL SDGGTGEDLQ DGGMQVEAFE KRIRCLEQEK 
       460        470        480        490        500
LELNRKLQES TQAVQSLHGS GRGAGTLGRD KEIKKLNEEI DRLKKKLADS 
       510        520        530        540        550
DRLEHQLEEA VTLRQDFESS STKLKALDKQ VKALKLEKED IHKQLVESLD 
       560        570        580        590        600
RLKSQTKELK DAHQQRKLAM QEFSEVNERM AELRSQKQRL SRQLRDKEEE 
       610        620        630        640        650
MEVVMQKIDA MRQDIRKTEK ARKELESQLE DARAEASKER KLREHSEVYS 
       660        670        680        690        700
KQLESELETL KVKQGAGRAS GLGAETQQEL TKLKSELDKK GLYYEEELVR 
       710        720        730        740        750
REASHTTEMK NLRKELQDSE GQQLSLHKEL LALKEKLEKA KRERQIEMEE 
       760        770        780        790        800
AINALKEQYE RERNLMSEDN RKLTAETDRL CSFVDKLTAQ NRQLEDELQE 
       810        820        830        840        850
LASKKESVAH WEAQIAEIIQ WVSDEKDARG YLQALASKMT EELESLRSSS 
       860        870        880        890        900
LGSRTLDPLW KVRRSQKLDM SARLELQSAL EAEIRAKQLV HDELRKVKAA 
       910        920        930        940        950
NISFESKLKD TEAKNRELEE QLENMKKEME ESRSRSDKGL KLPDFQDSIF 
       960        970        980        990       1000
DYFNTSPLAH ELTFRTSSVG DVDVAPQKTD IPPSSPSAAT EQDEAVKPQA 
      1010       1020       1030       1040       1050
TTPATPSPMY QPTLTAPKPK AHQLSIKTFS SPTQCTHCTS LMVGQMRQGY 
      1060       1070       1080       1090       1100
ACEVCSFICH VSCKDNAPQL CPIPPEQTKR PLGIDVQRGI GTAYKGFVRI 
      1110       1120       1130       1140       1150
PKPTGVKKGW QRAYAVVCDC KLFLYEVPEG KSTQPVVMAS QVLDLRDEEF 
      1160       1170       1180       1190       1200
SVSSVLASDV IHANHKDVPC IFRVTSSALK SSIRPVPLLI LAESEAEKRK 
      1210       1220       1230       1240       1250
WVGILEGLQS ILAKNRLKNR VVHVLHEAYD SSLPAIKTTL SAAIVDRERI 
      1260       1270       1280       1290       1300
VLGTEDGLFV VEITRDVIVR AADCKKVCQI ELIPKEKMVA LLSGRNRHVH 
      1310       1320       1330       1340       1350
LYPWAALEGA EGGFDAKLTD TRGCQAMTIG NLRPGGPACL FAGVKRQVFC 
      1360       1370       1380       1390       1400
YEITRAKPHH RKLWEVQAPG VVQWLGIIRE RICVGYPSGF ALLAMQGESS 
      1410       1420       1430       1440       1450
PVSLVSPGDP SLAFLAQQPL DALHAMEVGS NELLLCFSQL GVYVDATGRR 
      1460       1470       1480       1490       1500
SRTQELMWPS TPLACSSNSN CLTVYSDYGV DVFDVHTMEW VQTISLRKIR 
      1510       1520       1530       1540       1550
PLNVEGSLNL LSIEQPHLIY FSNNSSDGCD LAIPETSDNS KKLMVRTRSK 
      1560       1570       1580       1590       1600
RKFLFKVPEE ERLQQRREML RDPEMRSKLI SHPTNFNHVA HMGPGDGMQV 
      1610       1620       1630       1640       1650
LMDLPLSVMP SSQDDLSKDK PRPLSSISRQ QRSKTHITRT ASGGGDFGGA 
      1660       1670       1680       1690       1700
GSSRSISDQD QDYEREPDSD STKHSTPSNS SNPSSPPSPN SPHRSQLTLD 

SLDQSLDG
Length:1,708
Mass (Da):193,138
Last modified:December 7, 2004 - v1
Checksum:iCE13DF712E06E5CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510992 Genomic DNA. No translation available.
BC163554 mRNA. Translation: AAI63554.1.
RefSeqiNP_001038590.1. NM_001045125.2.
UniGeneiDr.67361.

Genome annotation databases

EnsembliENSDART00000049437; ENSDARP00000049436; ENSDARG00000019383.
GeneIDi567039.
KEGGidre:567039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510992 Genomic DNA. No translation available.
BC163554 mRNA. Translation: AAI63554.1.
RefSeqiNP_001038590.1. NM_001045125.2.
UniGeneiDr.67361.

3D structure databases

SMRiQ5TZ42. Positions 37-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000049436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000049437; ENSDARP00000049436; ENSDARG00000019383.
GeneIDi567039.
KEGGidre:567039.

Organism-specific databases

CTDi9578.
ZFINiZDB-GENE-030131-3647. cdc42bpb.

Phylogenomic databases

eggNOGiENOG410IT51. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000294133.
HOVERGENiHBG055933.
KOiK16307.
OMAiSCFSDRG.
OrthoDBiEOG091G09EX.
PhylomeDBiQ5TZ42.
TreeFamiTF313551.

Gene expression databases

BgeeiENSDARG00000019383.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR001180. CNH_dom.
IPR000095. CRIB_dom.
IPR031597. KELK.
IPR011009. Kinase-like_dom.
IPR014930. Myotonic_dystrophy_kinase_coil.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00780. CNH. 1 hit.
PF08826. DMPK_coil. 1 hit.
PF15796. KELK. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
ProDomiPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00285. PBD. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50108. CRIB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TZ42_DANRE
AccessioniPrimary (citable) accession number: Q5TZ42
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.