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Protein
Submitted name:

CDC42 binding protein kinase beta (DMPK-like)

Gene

cdc42bpb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
CDC42 binding protein kinase beta (DMPK-like)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:cdc42bpbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030131-3647. cdc42bpb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000049436.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 342267Protein kinaseInterPro annotationAdd
BLAST
Domaini343 – 41371AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini1021 – 107151Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini1091 – 1210120PHInterPro annotationAdd
BLAST
Domaini1236 – 1509274CNHInterPro annotationAdd
BLAST
Domaini1580 – 159314CRIBInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili436 – 46328Sequence analysisAdd
BLAST
Coiled coili483 – 51028Sequence analysisAdd
BLAST
Coiled coili517 – 642126Sequence analysisAdd
BLAST
Coiled coili695 – 77682Sequence analysisAdd
BLAST
Coiled coili784 – 81431Sequence analysisAdd
BLAST
Coiled coili901 – 93535Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.SAAS annotation
Contains AGC-kinase C-terminal domain.SAAS annotation
Contains PH domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410IT51. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000294133.
HOVERGENiHBG055933.
KOiK16307.
OMAiSCFSDRG.
OrthoDBiEOG7F511X.
TreeFamiTF313551.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR001180. CNH_dom.
IPR000095. CRIB_dom.
IPR031597. KELK.
IPR011009. Kinase-like_dom.
IPR014930. Myotonic_dystrophy_kinase_coil.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00780. CNH. 1 hit.
PF08826. DMPK_coil. 1 hit.
PF15796. KELK. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
ProDomiPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00285. PBD. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50108. CRIB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TZ42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKVRLKKL EQLLLDGHQK NDKSLSVETL LDILICLYNE CSNSPLKREK
60 70 80 90 100
HVTDFLEWVK PFTTTVKEMR LHRDDFEMLK VIGRGAFGEV AVVKMKHTER
110 120 130 140 150
VYAMKILNKW EMLKRAETAC FREERNVLVN GDCQWITTLH YAFQDDNYLY
160 170 180 190 200
LVMDYYVGGD LLTLLSKFED RLPEDMAKFY VAEMVLAIHS IHQQRYVHRD
210 220 230 240 250
IKPDNVLLDM NGHIRLADFG SCLKMMQDGT VQSSVAVGTP DYISPEILQA
260 270 280 290 300
MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF
310 320 330 340 350
QFPSHITDVS EDAKDLIQRL ICSRERRLGQ HGIEEFRKHA FFSGIDWENI
360 370 380 390 400
RNMEAPYIPD VSSPSDTSNF DVDDDVLKNP DIAPPVSHTG FTGQHLPFVG
410 420 430 440 450
FTYTTESCFS DGGSMRGVAL SDGGTGEDLQ DGGMQVEAFE KRIRCLEQEK
460 470 480 490 500
LELNRKLQES TQAVQSLHGS GRGAGTLGRD KEIKKLNEEI DRLKKKLADS
510 520 530 540 550
DRLEHQLEEA VTLRQDFESS STKLKALDKQ VKALKLEKED IHKQLVESLD
560 570 580 590 600
RLKSQTKELK DAHQQRKLAM QEFSEVNERM AELRSQKQRL SRQLRDKEEE
610 620 630 640 650
MEVVMQKIDA MRQDIRKTEK ARKELESQLE DARAEASKER KLREHSEVYS
660 670 680 690 700
KQLESELETL KVKQGAGRAS GLGAETQQEL TKLKSELDKK GLYYEEELVR
710 720 730 740 750
REASHTTEMK NLRKELQDSE GQQLSLHKEL LALKEKLEKA KRERQIEMEE
760 770 780 790 800
AINALKEQYE RERNLMSEDN RKLTAETDRL CSFVDKLTAQ NRQLEDELQE
810 820 830 840 850
LASKKESVAH WEAQIAEIIQ WVSDEKDARG YLQALASKMT EELESLRSSS
860 870 880 890 900
LGSRTLDPLW KVRRSQKLDM SARLELQSAL EAEIRAKQLV HDELRKVKAA
910 920 930 940 950
NISFESKLKD TEAKNRELEE QLENMKKEME ESRSRSDKGL KLPDFQDSIF
960 970 980 990 1000
DYFNTSPLAH ELTFRTSSVG DVDVAPQKTD IPPSSPSAAT EQDEAVKPQA
1010 1020 1030 1040 1050
TTPATPSPMY QPTLTAPKPK AHQLSIKTFS SPTQCTHCTS LMVGQMRQGY
1060 1070 1080 1090 1100
ACEVCSFICH VSCKDNAPQL CPIPPEQTKR PLGIDVQRGI GTAYKGFVRI
1110 1120 1130 1140 1150
PKPTGVKKGW QRAYAVVCDC KLFLYEVPEG KSTQPVVMAS QVLDLRDEEF
1160 1170 1180 1190 1200
SVSSVLASDV IHANHKDVPC IFRVTSSALK SSIRPVPLLI LAESEAEKRK
1210 1220 1230 1240 1250
WVGILEGLQS ILAKNRLKNR VVHVLHEAYD SSLPAIKTTL SAAIVDRERI
1260 1270 1280 1290 1300
VLGTEDGLFV VEITRDVIVR AADCKKVCQI ELIPKEKMVA LLSGRNRHVH
1310 1320 1330 1340 1350
LYPWAALEGA EGGFDAKLTD TRGCQAMTIG NLRPGGPACL FAGVKRQVFC
1360 1370 1380 1390 1400
YEITRAKPHH RKLWEVQAPG VVQWLGIIRE RICVGYPSGF ALLAMQGESS
1410 1420 1430 1440 1450
PVSLVSPGDP SLAFLAQQPL DALHAMEVGS NELLLCFSQL GVYVDATGRR
1460 1470 1480 1490 1500
SRTQELMWPS TPLACSSNSN CLTVYSDYGV DVFDVHTMEW VQTISLRKIR
1510 1520 1530 1540 1550
PLNVEGSLNL LSIEQPHLIY FSNNSSDGCD LAIPETSDNS KKLMVRTRSK
1560 1570 1580 1590 1600
RKFLFKVPEE ERLQQRREML RDPEMRSKLI SHPTNFNHVA HMGPGDGMQV
1610 1620 1630 1640 1650
LMDLPLSVMP SSQDDLSKDK PRPLSSISRQ QRSKTHITRT ASGGGDFGGA
1660 1670 1680 1690 1700
GSSRSISDQD QDYEREPDSD STKHSTPSNS SNPSSPPSPN SPHRSQLTLD

SLDQSLDG
Length:1,708
Mass (Da):193,138
Last modified:December 7, 2004 - v1
Checksum:iCE13DF712E06E5CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510992 Genomic DNA. No translation available.
BC163554 mRNA. Translation: AAI63554.1.
RefSeqiNP_001038590.1. NM_001045125.2.
UniGeneiDr.67361.

Genome annotation databases

EnsembliENSDART00000049437; ENSDARP00000049436; ENSDARG00000019383.
GeneIDi567039.
KEGGidre:567039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510992 Genomic DNA. No translation available.
BC163554 mRNA. Translation: AAI63554.1.
RefSeqiNP_001038590.1. NM_001045125.2.
UniGeneiDr.67361.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000049436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000049437; ENSDARP00000049436; ENSDARG00000019383.
GeneIDi567039.
KEGGidre:567039.

Organism-specific databases

CTDi9578.
ZFINiZDB-GENE-030131-3647. cdc42bpb.

Phylogenomic databases

eggNOGiENOG410IT51. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000294133.
HOVERGENiHBG055933.
KOiK16307.
OMAiSCFSDRG.
OrthoDBiEOG7F511X.
TreeFamiTF313551.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR001180. CNH_dom.
IPR000095. CRIB_dom.
IPR031597. KELK.
IPR011009. Kinase-like_dom.
IPR014930. Myotonic_dystrophy_kinase_coil.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00780. CNH. 1 hit.
PF08826. DMPK_coil. 1 hit.
PF15796. KELK. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
ProDomiPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00285. PBD. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50108. CRIB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  3. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ5TZ42_DANRE
AccessioniPrimary (citable) accession number: Q5TZ42
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.