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Protein

Olfactory receptor 2G6

Gene

OR2G6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2G6
Gene namesi
Name:OR2G6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27019. OR2G6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31624CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671228.

Polymorphism and mutation databases

BioMutaiOR2G6.
DMDMi74762248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 2G6PRO_0000150478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5TZ20.
PRIDEiQ5TZ20.

PTM databases

iPTMnetiQ5TZ20.
PhosphoSiteiQ5TZ20.

Expressioni

Gene expression databases

CleanExiHS_OR2G6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341291.

Structurei

3D structure databases

ProteinModelPortaliQ5TZ20.
SMRiQ5TZ20. Positions 1-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ5TZ20.
KOiK04257.
OMAiKNMSYGG.
OrthoDBiEOG751NFX.
PhylomeDBiQ5TZ20.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TZ20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEETNNSSEK GFLLLGFSDQ PQLERFLFAI ILYFYVLSLL GNTALILVCC
60 70 80 90 100
LDSRLHTPMY FFLSNLSCVD ICFTTSVAPQ LLVTMNKKDK TMSYGGCVAQ
110 120 130 140 150
LYVAMGLGSS ECILLAVMAY DRYAAVCRPL RYIAIMHPRF CASLAGGAWL
160 170 180 190 200
SGLITSLIQC SLTVQLPLCG HRTLDHIFCE VPVLIKLACV DTTFNEAELF
210 220 230 240 250
VASVVFLIVP VLLILVSYGF ITQAVLRIKS AAGRQKAFGT CSSHLVVVII
260 270 280 290 300
FYGTIIFMYL QPANRRSKNQ GKFVSLFYTI VTPLLNPIIY TLRNKDVKGA
310
LRTLILGSAA GQSHKD
Length:316
Mass (Da):34,890
Last modified:December 7, 2004 - v1
Checksum:i2702925101A6CA34
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591M → V.
Corresponds to variant rs58955396 [ dbSNP | Ensembl ].
VAR_062020
Natural varianti258 – 2581M → L.
Corresponds to variant rs9330305 [ dbSNP | Ensembl ].
VAR_053142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537158 Genomic DNA. Translation: CAH71962.1.
CH471148 Genomic DNA. Translation: EAW77231.1.
BC137245 mRNA. Translation: AAI37246.1.
BC137266 mRNA. Translation: AAI37267.1.
CCDSiCCDS31119.1.
RefSeqiNP_001013373.1. NM_001013355.1.
UniGeneiHs.553784.

Genome annotation databases

EnsembliENST00000343414; ENSP00000341291; ENSG00000188558.
GeneIDi391211.
KEGGihsa:391211.
UCSCiuc001ien.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537158 Genomic DNA. Translation: CAH71962.1.
CH471148 Genomic DNA. Translation: EAW77231.1.
BC137245 mRNA. Translation: AAI37246.1.
BC137266 mRNA. Translation: AAI37267.1.
CCDSiCCDS31119.1.
RefSeqiNP_001013373.1. NM_001013355.1.
UniGeneiHs.553784.

3D structure databases

ProteinModelPortaliQ5TZ20.
SMRiQ5TZ20. Positions 1-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341291.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ5TZ20.
PhosphoSiteiQ5TZ20.

Polymorphism and mutation databases

BioMutaiOR2G6.
DMDMi74762248.

Proteomic databases

PaxDbiQ5TZ20.
PRIDEiQ5TZ20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343414; ENSP00000341291; ENSG00000188558.
GeneIDi391211.
KEGGihsa:391211.
UCSCiuc001ien.1. human.

Organism-specific databases

CTDi391211.
GeneCardsiOR2G6.
HGNCiHGNC:27019. OR2G6.
neXtProtiNX_Q5TZ20.
PharmGKBiPA142671228.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ5TZ20.
KOiK04257.
OMAiKNMSYGG.
OrthoDBiEOG751NFX.
PhylomeDBiQ5TZ20.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2G6.
GenomeRNAii391211.
PROiQ5TZ20.

Gene expression databases

CleanExiHS_OR2G6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOR2G6_HUMAN
AccessioniPrimary (citable) accession number: Q5TZ20
Secondary accession number(s): B2RP33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.