Reviewed, UniProtKB/Swiss-Prot Q5TYW8 (PRAM3_HUMAN)

Names and origin

Protein names

Recommended name:
PRAME family member 3

Gene names

Name:

PRAMEF3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the PRAME family. Contains 3 LRR (leucine-rich) repeats.

Ontologies

Keywords
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	PRAME family member 3		PRO_0000156977
Regions
	Repeat	15 – 38	24	LRR 1
	Repeat	319 – 342	24	LRR 2
	Repeat	348 – 375	28	LRR 3

Sequences

	Sequence		Length	Mass (Da)
	Q5TYW8-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: A6CAEB3D889FBB9B	FASTA	479	55,198
	10 20 30 40 50 60 MSLQAPRRLL ELAGQSLLGD QALAISILDE LPRELFPPLF VEAFTSRRCE VLKVMVQAWP 70 80 90 100 110 120 FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRRKL QVLELRDVDE NFWTIWSGAR 130 140 150 160 170 180 PLSCSPEAMS KRQTVEDCPR TGEKQPLKVF MDVCLKEKFM DEDLSFFSGW VQHRRGSVHL 190 200 210 220 230 240 CCTKVVNYSM SILNFRNILE TVYPDSIQVL EIWNMCWPCM IVEFIRYLSQ MRNLRKLFIS 250 260 270 280 290 300 DGCRYLLSSD SQEQLVAEFS SVLLRLEYLQ MLYVRRVCFF RGHLDQLIRC LRSPLETLAL 310 320 330 340 350 360 TYGFLEKVDL KCLPRYPSLS QLKQLNLSHG ALRFIRLEPL RALLEKVAAT LQTLFLVDCG 370 380 390 400 410 420 IRDSKLRVIL PALSCCSNLT TFCFHGNDTS MDGLKDLLRH TGRLSNLSLE TYPAPRESLD 430 440 450 460 470 DRGRVISELL TPLQAELMRI LREVREPKRI FFGPVSCPCC GTSPTEQLEF NFCLWGRPA

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX649449 Genomic DNA. Translation: CAH71686.1.
IPI	IPI00607831.
UniGene	Hs.558935
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q5TYW8.
Genome annotation databases
Ensembl	ENST00000353410; ENSP00000334892; ENSG00000204503; Homo sapiens. [Genome view] ENST00000376173; ENSP00000365343; ENSG00000204503; Homo sapiens. [Genome view]
UCSC	uc001aut.1. human.
Organism-specific databases
GeneCards	GC01M013200.
HGNC	HGNC:14087. PRAMEF3.
PharmGKB	PA142671140.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13767.
HOGENOM	HBG506079.
HOVERGEN	HBG006326.
InParanoid	Q5TYW8.
Gene expression databases
CleanEx	HS_PRAMEF3.
Genevestigator	Q5TYW8.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	107203.

Entry information

Entry name

PRAM3_HUMAN

Accession

Primary (citable) accession number: Q5TYW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 7, 2004
Last modified:	March 2, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.