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Protein

Ankyrin repeat domain-containing protein 20A1

Gene

ANKRD20A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 20A1
Gene namesi
Name:ANKRD20A1
Synonyms:ANKRD20A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23665. ANKRD20A1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953648.

Polymorphism and mutation databases

BioMutaiANKRD20A1.
DMDMi74746676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 823823Ankyrin repeat domain-containing protein 20A1PRO_0000240834Add
BLAST

Proteomic databases

PaxDbiQ5TYW2.
PRIDEiQ5TYW2.

PTM databases

iPTMnetiQ5TYW2.
PhosphoSiteiQ5TYW2.

Expressioni

Gene expression databases

BgeeiENSG00000196774.
CleanExiHS_ANKRD20A1.
ExpressionAtlasiQ5TYW2. baseline.
GenevisibleiQ5TYW2. HS.

Organism-specific databases

HPAiHPA043239.
HPA047112.
HPA047167.
HPA047766.
HPA051753.

Interactioni

Protein-protein interaction databases

BioGridi123947. 1 interaction.
IntActiQ5TYW2. 1 interaction.
MINTiMINT-2817167.
STRINGi9606.ENSP00000366697.

Structurei

3D structure databases

ProteinModelPortaliQ5TYW2.
SMRiQ5TYW2. Positions 28-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati66 – 9530ANK 1Add
BLAST
Repeati99 – 12830ANK 2Add
BLAST
Repeati132 – 16130ANK 3Add
BLAST
Repeati165 – 19430ANK 4Add
BLAST
Repeati198 – 22730ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili431 – 48050Sequence analysisAdd
BLAST
Coiled coili565 – 724160Sequence analysisAdd
BLAST
Coiled coili776 – 80530Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000230851.
HOVERGENiHBG079958.
InParanoidiQ5TYW2.
KOiK17299.
OMAiTILLHER.
OrthoDBiEOG091G077A.
PhylomeDBiQ5TYW2.
TreeFamiTF333496.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TYW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE
60 70 80 90 100
RCLARRSGDL DALDKQHRTA LHLACTSGHV QVVTLLVNRK CQIDVCDKEN
110 120 130 140 150
RTPLIQAVHC QEEACAVILL EHGANPNLKD IYGNTALHYA VYSESTSLAE
160 170 180 190 200
KLLSHGAHIE ALDKDNNTPL LFAIICKKEK MVEFLLKKKA SSHAVDRLRR
210 220 230 240 250
SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI SHHLTKIQQQ
260 270 280 290 300
ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC
310 320 330 340 350
VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV
360 370 380 390 400
QRKNVQTLRA EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS
410 420 430 440 450
ENICDSTSSA AAGRLTQQRK IGKTYPQQFP KKLKEEHDRC TLKQENEEKT
460 470 480 490 500
NVNMLYKKNR EELERKEKQY KKEVEAKQLE PTVQSLEMKS KTARNTPNWD
510 520 530 540 550
FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN KYLKDIKIVK
560 570 580 590 600
ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
610 620 630 640 650
RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI
660 670 680 690 700
SKVKAENEFL TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS
710 720 730 740 750
QTQQQTQEMK EMYQNAEAKV NNSTGKWNCV EERICHLQRE NAWLVQQLDD
760 770 780 790 800
VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE KSKKLMNECD HLKESLFQYE
810 820
REKTEGVVSI KEDKYFQTSR KTI
Length:823
Mass (Da):94,048
Last modified:December 7, 2004 - v1
Checksum:i0AE8585829E6E91B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761T → A in CAB66727 (PubMed:11230166).Curated
Sequence conflicti128 – 1281L → F in CAB66727 (PubMed:11230166).Curated
Sequence conflicti499 – 4991W → R in CAB66727 (PubMed:11230166).Curated
Sequence conflicti679 – 6791R → C in CAB66727 (PubMed:11230166).Curated
Sequence conflicti772 – 7721G → E in CAB66727 (PubMed:11230166).Curated
Sequence conflicti805 – 8051E → G in CAB66727 (PubMed:11230166).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136793 mRNA. Translation: CAB66727.1.
BX649567 Genomic DNA. Translation: CAH71137.1.
CCDSiCCDS6620.1.
RefSeqiNP_115626.2. NM_032250.3.
UniGeneiHs.632671.

Genome annotation databases

EnsembliENST00000562196; ENSP00000477695; ENSG00000260691.
GeneIDi84210.
KEGGihsa:84210.
UCSCiuc004aeu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136793 mRNA. Translation: CAB66727.1.
BX649567 Genomic DNA. Translation: CAH71137.1.
CCDSiCCDS6620.1.
RefSeqiNP_115626.2. NM_032250.3.
UniGeneiHs.632671.

3D structure databases

ProteinModelPortaliQ5TYW2.
SMRiQ5TYW2. Positions 28-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123947. 1 interaction.
IntActiQ5TYW2. 1 interaction.
MINTiMINT-2817167.
STRINGi9606.ENSP00000366697.

PTM databases

iPTMnetiQ5TYW2.
PhosphoSiteiQ5TYW2.

Polymorphism and mutation databases

BioMutaiANKRD20A1.
DMDMi74746676.

Proteomic databases

PaxDbiQ5TYW2.
PRIDEiQ5TYW2.

Protocols and materials databases

DNASUi84210.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000562196; ENSP00000477695; ENSG00000260691.
GeneIDi84210.
KEGGihsa:84210.
UCSCiuc004aeu.4. human.

Organism-specific databases

CTDi84210.
GeneCardsiANKRD20A1.
H-InvDBHIX0008066.
HIX0019279.
HIX0031746.
HIX0032459.
HIX0034914.
HIX0035212.
HIX0040875.
HIX0060080.
HIX0169086.
HGNCiHGNC:23665. ANKRD20A1.
HPAiHPA043239.
HPA047112.
HPA047167.
HPA047766.
HPA051753.
neXtProtiNX_Q5TYW2.
PharmGKBiPA134953648.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000230851.
HOVERGENiHBG079958.
InParanoidiQ5TYW2.
KOiK17299.
OMAiTILLHER.
OrthoDBiEOG091G077A.
PhylomeDBiQ5TYW2.
TreeFamiTF333496.

Miscellaneous databases

GenomeRNAii84210.
PROiQ5TYW2.

Gene expression databases

BgeeiENSG00000196774.
CleanExiHS_ANKRD20A1.
ExpressionAtlasiQ5TYW2. baseline.
GenevisibleiQ5TYW2. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA20A1_HUMAN
AccessioniPrimary (citable) accession number: Q5TYW2
Secondary accession number(s): Q9H0H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.