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Q5TYW2 (A20A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 20A1
Gene names
Name:ANKRD20A1
Synonyms:ANKRD20A
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length823 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
   DomainANK repeat
Coiled coil
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentplasma membrane

Inferred from direct assay. Source: LIFEdb

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 823823Ankyrin repeat domain-containing protein 20A1
PRO_0000240834

Regions

Repeat66 – 9530ANK 1
Repeat99 – 12830ANK 2
Repeat132 – 16130ANK 3
Repeat165 – 19430ANK 4
Repeat198 – 22730ANK 5
Coiled coil431 – 48050 Potential
Coiled coil565 – 724160 Potential
Coiled coil776 – 80530 Potential

Amino acid modifications

Modified residue2971Phosphothreonine Ref.3

Experimental info

Sequence conflict761T → A in CAB66727. Ref.1
Sequence conflict1281L → F in CAB66727. Ref.1
Sequence conflict4991W → R in CAB66727. Ref.1
Sequence conflict6791R → C in CAB66727. Ref.1
Sequence conflict7721G → E in CAB66727. Ref.1
Sequence conflict8051E → G in CAB66727. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q5TYW2 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 0AE8585829E6E91B

FASTA82394,048
        10         20         30         40         50         60 
MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL 

        70         80         90        100        110        120 
DALDKQHRTA LHLACTSGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL 

       130        140        150        160        170        180 
EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK 

       190        200        210        220        230        240 
MVEFLLKKKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI 

       250        260        270        280        290        300 
SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC 

       310        320        330        340        350        360 
VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA 

       370        380        390        400        410        420 
EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK 

       430        440        450        460        470        480 
IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE 

       490        500        510        520        530        540 
PTVQSLEMKS KTARNTPNWD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN 

       550        560        570        580        590        600 
KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK 

       610        620        630        640        650        660 
RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI SKVKAENEFL 

       670        680        690        700        710        720 
TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS QTQQQTQEMK EMYQNAEAKV 

       730        740        750        760        770        780 
NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE 

       790        800        810        820 
KSKKLMNECD HLKESLFQYE REKTEGVVSI KEDKYFQTSR KTI

« Hide

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-297, MASS SPECTROMETRY.
Tissue: Leukemic T-cell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL136793 mRNA. Translation: CAB66727.1.
BX649567 Genomic DNA. Translation: CAH71137.1.
IPIIPI00020265.
RefSeqNP_115626.2. NM_032250.3.
UniGeneHs.632671.

3D structure databases

ProteinModelPortalQ5TYW2.
SMRQ5TYW2. Positions 6-255.
ModBaseSearch...

PTM databases

PhosphoSiteQ5TYW2.

Polymorphism databases

DMDM74746676.

Proteomic databases

PRIDEQ5TYW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377477; ENSP00000366697; ENSG00000196774.
GeneID84210.
KEGGhsa:84210.
UCSCuc004aeu.1. human.

Organism-specific databases

CTD84210.
GeneCardsGC09P067926.
HGNCHGNC:23665. ANKRD20A1.
neXtProtNX_Q5TYW2.
PharmGKBPA134953648.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG12549.
GeneTreeENSGT00560000076605.
HOGENOMHBG100718.
HOVERGENHBG079958.
InParanoidQ5TYW2.
OrthoDBEOG4CNQQH.
PhylomeDBQ5TYW2.

Gene expression databases

BgeeQ5TYW2.
CleanExHS_ANKRD20A1.
GenevestigatorQ5TYW2.
GermOnlineENSG00000196774. Homo sapiens.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMSSF48403. ANK. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio73621.

Entry information

Entry nameA20A1_HUMAN
AccessionPrimary (citable) accession number: Q5TYW2
Secondary accession number(s): Q9H0H6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents