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Protein

Zinc finger protein 658

Gene

ZNF658

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri325 – 34723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37524C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40626C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri602 – 62423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri630 – 65223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri658 – 68023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri686 – 70823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri742 – 76423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri798 – 82023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri826 – 84823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri854 – 87623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri882 – 90423C2H2-type 19; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri910 – 93223C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri938 – 96023C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri966 – 98823C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri994 – 101623C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1022 – 104524C2H2-type 24PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular response to zinc ion Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • ribosome biogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Ribosome biogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 658
Gene namesi
Name:ZNF658
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25226. ZNF658.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907871.

Polymorphism and mutation databases

BioMutaiZNF658.
DMDMi134035376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Zinc finger protein 658PRO_0000280433Add
BLAST

Proteomic databases

MaxQBiQ5TYW1.
PaxDbiQ5TYW1.
PeptideAtlasiQ5TYW1.
PRIDEiQ5TYW1.

PTM databases

iPTMnetiQ5TYW1.
PhosphoSiteiQ5TYW1.

Expressioni

Gene expression databases

BgeeiENSG00000196409.
CleanExiHS_ZNF658.
ExpressionAtlasiQ5TYW1. baseline and differential.
GenevisibleiQ5TYW1. HS.

Organism-specific databases

HPAiHPA047730.
HPA048668.

Interactioni

Protein-protein interaction databases

BioGridi117580. 1 interaction.
STRINGi9606.ENSP00000366853.

Structurei

3D structure databases

ProteinModelPortaliQ5TYW1.
SMRiQ5TYW1. Positions 257-1051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 24 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri325 – 34723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37524C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40626C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri602 – 62423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri630 – 65223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri658 – 68023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri686 – 70823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri742 – 76423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri798 – 82023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri826 – 84823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri854 – 87623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri882 – 90423C2H2-type 19; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri910 – 93223C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri938 – 96023C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri966 – 98823C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri994 – 101623C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1022 – 104524C2H2-type 24PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5TYW1.
KOiK09228.
OMAiYNKVHMA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5TYW1.
TreeFamiTF350905.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TYW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNMSQASVSF QDVTVEFTRE EWQHLGPVER TLYRDVMLEN YSHLISVGYC
60 70 80 90 100
ITKPKVISKL EKGEEPWSLE DEFLNQRYPG YFKVDHIKGI REKQEKPLWQ
110 120 130 140 150
EIFISDADKT LSKEGQKVLE KPFNLEIAPE LSEKISCKCD SHRMNLPVAS
160 170 180 190 200
QLIISERKYS RKKTEYMNVC EKLQLDIKHE KAHAEEKSYE HGENAKAFSY
210 220 230 240 250
KKDQHWKFQT LEESFECDGS GQGLYDKTIC ITPQSFLTGE KSCKDDEFRK
260 270 280 290 300
NFDKITLFNH MRTDTRGKCS DLNEYGTSCD KTTAVEYNKV HMAMTHYECN
310 320 330 340 350
ERGINFSRKS PLTQSQRTIT GWSAFESNKC EENFSQSSAH IVHQKTQAGD
360 370 380 390 400
KFGEHNECTD ALYQKLDFTA HQRIHTEDKF YLSDEHGKCR KSFYRKAHLI
410 420 430 440 450
QHQRPHSGEK TYQYEECAKS FCSSSHPIQH PGTYVGFKLY ECNECGKAFC
460 470 480 490 500
QNSNLSKHLR IHTKEKPCDN NGCGRSYKSP LIGHQKTDAE MELCGGSEYG
510 520 530 540 550
KTSHLKGHQR ILMGEKPYEC IECGKTFSKT SHLRAHQRIH TGEKPYECVE
560 570 580 590 600
CEKTFSHKTH LSVHQRVHTG EKPYECNDCG KSFTYNSALR AHQRIHTGEK
610 620 630 640 650
PYECSDCEKT FAHNSALRAH HRIHTGEKPY ECNECGRSFA HISVLKAHQR
660 670 680 690 700
IHTGEKPYEC NECGRSFTYN SALRAHQRIH TGRKPYECSD CEKTFAHNSA
710 720 730 740 750
LKIHQRIHTG EKPYECNECE KTFAHNSALR AHQNIHTGEK LYECSECGKT
760 770 780 790 800
FFQKTRLSTH RRIHTGEKPY ECSKCGKTFS QKSYLSGHER IHTGEKPYEC
810 820 830 840 850
NVCGKTFVYK AALIVHQRIH TGEKPYECNQ CGKTFSQRTH LCAHQRIHTG
860 870 880 890 900
EKPYECNECG KTFADNSALR AHHRIHTGEK PYECNDCGKT FSKTSHLRAH
910 920 930 940 950
LRTRSGEKPY ECSECGKTFS EKSYVSAHQR VHTGEKPYEC NVCGKPFAHN
960 970 980 990 1000
STLRVHQRIH TGEKSYECND CGKTFSQKSH LSAHQRIHTG EKPYECNECG
1010 1020 1030 1040 1050
KAFAQNSTLR VHQRIHTGEK PYECDECGKT FVRKAALRVH HTRMHTREKT

LACNGFGKS
Length:1,059
Mass (Da):122,274
Last modified:February 20, 2007 - v2
Checksum:i3007C61F09413440
GO
Isoform 2 (identifier: Q5TYW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-617: EKPYECSDCEKTFAHNSAL → LAVCHVGILMATKSLFHQS
     618-1059: Missing.

Note: No experimental confirmation available.
Show »
Length:617
Mass (Da):71,378
Checksum:i090B60267A1DDFD3
GO

Sequence cautioni

The sequence AAH31626 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14145 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB53677 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681S → Y.
Corresponds to variant rs2065444 [ dbSNP | Ensembl ].
VAR_052888

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei599 – 61719EKPYE…HNSAL → LAVCHVGILMATKSLFHQS in isoform 2. 1 PublicationVSP_023671Add
BLAST
Alternative sequencei618 – 1059442Missing in isoform 2. 1 PublicationVSP_023672Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022636 mRNA. Translation: BAB14145.1. Different initiation.
AK057375 mRNA. Translation: BAB71457.1. Different termination.
BX664608, AL353770 Genomic DNA. Translation: CAH70029.2.
AL353770, BX664608 Genomic DNA. Translation: CAM18525.1.
BC031626 mRNA. Translation: AAH31626.1. Different initiation.
AL110217 mRNA. Translation: CAB53677.2. Different initiation.
CCDSiCCDS75846.1. [Q5TYW1-1]
PIRiT14757.
RefSeqiNP_001304845.1. NM_001317916.1. [Q5TYW1-1]
NP_149350.3. NM_033160.6. [Q5TYW1-1]
XP_005272572.1. XM_005272515.4. [Q5TYW1-1]
XP_011543981.1. XM_011545679.2. [Q5TYW1-1]
UniGeneiHs.522147.

Genome annotation databases

EnsembliENST00000612867; ENSP00000482540; ENSG00000274349. [Q5TYW1-1]
ENST00000621410; ENSP00000482447; ENSG00000274349. [Q5TYW1-1]
ENST00000622180; ENSP00000480919; ENSG00000274349. [Q5TYW1-2]
GeneIDi26149.
KEGGihsa:26149.
UCSCiuc004abs.2. human. [Q5TYW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022636 mRNA. Translation: BAB14145.1. Different initiation.
AK057375 mRNA. Translation: BAB71457.1. Different termination.
BX664608, AL353770 Genomic DNA. Translation: CAH70029.2.
AL353770, BX664608 Genomic DNA. Translation: CAM18525.1.
BC031626 mRNA. Translation: AAH31626.1. Different initiation.
AL110217 mRNA. Translation: CAB53677.2. Different initiation.
CCDSiCCDS75846.1. [Q5TYW1-1]
PIRiT14757.
RefSeqiNP_001304845.1. NM_001317916.1. [Q5TYW1-1]
NP_149350.3. NM_033160.6. [Q5TYW1-1]
XP_005272572.1. XM_005272515.4. [Q5TYW1-1]
XP_011543981.1. XM_011545679.2. [Q5TYW1-1]
UniGeneiHs.522147.

3D structure databases

ProteinModelPortaliQ5TYW1.
SMRiQ5TYW1. Positions 257-1051.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117580. 1 interaction.
STRINGi9606.ENSP00000366853.

PTM databases

iPTMnetiQ5TYW1.
PhosphoSiteiQ5TYW1.

Polymorphism and mutation databases

BioMutaiZNF658.
DMDMi134035376.

Proteomic databases

MaxQBiQ5TYW1.
PaxDbiQ5TYW1.
PeptideAtlasiQ5TYW1.
PRIDEiQ5TYW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612867; ENSP00000482540; ENSG00000274349. [Q5TYW1-1]
ENST00000621410; ENSP00000482447; ENSG00000274349. [Q5TYW1-1]
ENST00000622180; ENSP00000480919; ENSG00000274349. [Q5TYW1-2]
GeneIDi26149.
KEGGihsa:26149.
UCSCiuc004abs.2. human. [Q5TYW1-1]

Organism-specific databases

CTDi26149.
GeneCardsiZNF658.
HGNCiHGNC:25226. ZNF658.
HPAiHPA047730.
HPA048668.
MIMi616290. gene.
neXtProtiNX_Q5TYW1.
PharmGKBiPA134907871.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5TYW1.
KOiK09228.
OMAiYNKVHMA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5TYW1.
TreeFamiTF350905.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii26149.
PROiQ5TYW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196409.
CleanExiHS_ZNF658.
ExpressionAtlasiQ5TYW1. baseline and differential.
GenevisibleiQ5TYW1. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN658_HUMAN
AccessioniPrimary (citable) accession number: Q5TYW1
Secondary accession number(s): Q6PIP3
, Q96M55, Q9H9S6, Q9UG02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.