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Protein

DNA repair protein RAD51 homolog

Gene

rad51

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-5685938. HDR through Single Strand Annealing (SSA).
R-DRE-5685942. HDR through Homologous Recombination (HRR).
R-DRE-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-DRE-5693579. Homologous DNA Pairing and Strand Exchange.
R-DRE-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homologUniRule annotation
Gene namesi
Name:rad51Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-040426-2286. rad51.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ5TYR1.

Expressioni

Gene expression databases

BgeeiENSDARG00000041411.
ExpressionAtlasiQ5TYR1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060705.

Structurei

3D structure databases

ProteinModelPortaliQ5TYR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 270RECA_2InterPro annotationAdd BLAST172
Domaini277 – 340RECA_3InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1433. Eukaryota.
COG0468. LUCA.
GeneTreeiENSGT00890000139508.
HOGENOMiHOG000227426.
HOVERGENiHBG001504.
InParanoidiQ5TYR1.
OMAiVGHTATF.
OrthoDBiEOG091G09QY.
PhylomeDBiQ5TYR1.
TreeFamiTF101218.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011941. DNA_recomb/repair_Rad51.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
PfamiView protein in Pfam
PF08423. Rad51. 1 hit.
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02239. recomb_RAD51. 1 hit.
PROSITEiView protein in PROSITE
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TYR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRNASRVE VEAEVEEEEN FGPQPVSRLE QSGISSSDIK KLEDGGFHTV
60 70 80 90 100
EAVAYAPKKE LLNIKGISEA KADKILTEAA KMVPMGFTTA TEFHQRRAEI
110 120 130 140 150
IQISTGSKEL DKLLQGGIET GSITEMFGEF RTGKTQLCHT LAVTCQLPID
160 170 180 190 200
QGGGEGKAMY IDTEGTFRPE RLLAVAERYG LVGSDVLDNV AYARAFNTDH
210 220 230 240 250
QTQLLYQASA MMTESRYALL IVDSATALYR TDYSGRGELS ARQGHLGRFL
260 270 280 290 300
RMLLRLADEF GVAVVITNQV VAQVDGAAMF SADPKKPIGG NILAHASTTR
310 320 330 340
LYLRKGRGET RICKIYDSPC LPEAEAMFAI NADGVGDAKD
Length:340
Mass (Da):37,024
Last modified:December 7, 2004 - v1
Checksum:i60F8589E55B0443A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936455 Genomic DNA. No translation available.
RefSeqiNP_998371.2. NM_213206.2.
UniGeneiDr.1514.

Genome annotation databases

EnsembliENSDART00000060706; ENSDARP00000060705; ENSDARG00000041411.
GeneIDi406487.

Similar proteinsi

Entry informationi

Entry nameiQ5TYR1_DANRE
AccessioniPrimary (citable) accession number: Q5TYR1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: January 31, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported