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Protein
Submitted name:

Death receptor 6

Gene

tnfrsf21

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • establishment of endothelial blood-brain barrier Source: ZFIN
  • signal transduction Source: InterPro
  • sprouting angiogenesis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Death receptor 6Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:tnfrsf21Imported
Synonyms:dr6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030131-5971. tnfrsf21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 637614Sequence analysisPRO_5007706605Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108459.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 11842TNFR-CysInterPro annotationAdd
BLAST
Domaini402 – 48584DeathInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
HOVERGENiHBG054218.
OMAiFSRPEHM.
OrthoDBiEOG786H2Q.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01971. TNFACTORR21.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TYN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKMSLIWS LTLLLTVVGD VLTHTLTPIP TTEKPLSPRH YHHIDPATGN
60 70 80 90 100
KLVCDKCPAG TYVSSHCTEA SVRECSPCPD GTFTRGENGV QQCHRCQRRC
110 120 130 140 150
QAPFIEKTPC TSTTDRLCVC PPGSFSQDGK CQRHSSCLPG WGVRKRGSET
160 170 180 190 200
EDVRCQPCQR GTFSAITSDS LRCQTHTDCP ALGLTLLIKG TKKTDNVCGP
210 220 230 240 250
NPASSVPVLL GEASVSTVSS TESAYRASTA VLPAADIQDE AEPVFSSTDM
260 270 280 290 300
ALGAQNFPTT TAYPEAIDKD GGLLIAATQD LPKSKLKLTL SRDLQLSNHQ
310 320 330 340 350
GVESMSESKA QGLGYRPIRR GAPRPSSHKH FDINEHLPWM IVLLLLLVLV
360 370 380 390 400
VIVVCSVKRS SRVLKKGPRQ DPSSIMEKAI HKKPSSPAQT KERWIYYSNG
410 420 430 440 450
QGVDILKLVA AQIGSQWIDL YKSLASATER EVAAFSNGYT ADHERAYAAL
460 470 480 490 500
QHWTIRDSDA NLAKLINALH RQRRIDVVDK IRSVMEDNPQ VDLNKLMTAV
510 520 530 540 550
NVSHCLSPSH KPLESPGVAV EQSPMERSRG FFPDESEPLL RCDSTSSKDS
560 570 580 590 600
ALSRTGSFIT KEKKDTVLRQ VRLDPCDLQP IFDDMLHILN PDELHVIEEI
610 620 630
PMAEDKLDRL FEIAGVKSQE ASQTLLDSVY SHLPDLL
Length:637
Mass (Da):70,000
Last modified:December 7, 2004 - v1
Checksum:i4B6F42D04A95479E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511269 Genomic DNA. No translation available.
BX842240 Genomic DNA. No translation available.
CR385023 Genomic DNA. No translation available.
DQ812118 mRNA. Translation: ABG91568.1.
UniGeneiDr.108925.

Genome annotation databases

EnsembliENSDART00000037855; ENSDARP00000036002; ENSDARG00000001807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511269 Genomic DNA. No translation available.
BX842240 Genomic DNA. No translation available.
CR385023 Genomic DNA. No translation available.
DQ812118 mRNA. Translation: ABG91568.1.
UniGeneiDr.108925.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000037855; ENSDARP00000036002; ENSDARG00000001807.

Organism-specific databases

ZFINiZDB-GENE-030131-5971. tnfrsf21.

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
HOVERGENiHBG054218.
OMAiFSRPEHM.
OrthoDBiEOG786H2Q.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01971. TNFACTORR21.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Delineation of the cell-extrinsic apoptosis pathway in the zebrafish."
    Eimon P.M., Kratz E., Varfolomeev E., Hymowitz S.G., Stern H., Zha J., Ashkenazi A.
    Cell Death Differ. 13:1619-1630(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TubingenImported.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  3. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ5TYN2_DANRE
AccessioniPrimary (citable) accession number: Q5TYN2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.