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Protein
Submitted name:

Death receptor 6

Gene

tnfrsf21

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • apoptotic signaling pathway Source: GO_Central
  • establishment of endothelial blood-brain barrier Source: ZFIN
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • sprouting angiogenesis Source: ZFIN

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Death receptor 6Imported
Submitted name:
Tumor necrosis factor receptor superfamily, member 21Imported
Gene namesi
Name:tnfrsf21Imported
Synonyms:dr6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030131-5971. tnfrsf21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500971262424 – 637Sequence analysisAdd BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 93PROSITE-ProRule annotation
Disulfide bondi100 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000001807.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108459.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 118TNFR-CysInterPro annotationAdd BLAST42
Repeati77 – 118TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini402 – 485DeathInterPro annotationAdd BLAST84

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
HOVERGENiHBG054218.
OMAiFSRPEHM.
OrthoDBiEOG091G03XW.

Family and domain databases

CDDicd08778. Death_TNFRSF21. 1 hit.
cd10583. TNFRSF21. 1 hit.
Gene3Di1.10.533.10. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR034037. TNFRSF21_death.
IPR034034. TNFRSF21_N.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
PRINTSiPR01971. TNFACTORR21.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TYN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKMSLIWS LTLLLTVVGD VLTHTLTPIP TTEKPLSPRH YHHIDPATGN
60 70 80 90 100
KLVCDKCPAG TYVSSHCTEA SVRECSPCPD GTFTRGENGV QQCHRCQRRC
110 120 130 140 150
QAPFIEKTPC TSTTDRLCVC PPGSFSQDGK CQRHSSCLPG WGVRKRGSET
160 170 180 190 200
EDVRCQPCQR GTFSAITSDS LRCQTHTDCP ALGLTLLIKG TKKTDNVCGP
210 220 230 240 250
NPASSVPVLL GEASVSTVSS TESAYRASTA VLPAADIQDE AEPVFSSTDM
260 270 280 290 300
ALGAQNFPTT TAYPEAIDKD GGLLIAATQD LPKSKLKLTL SRDLQLSNHQ
310 320 330 340 350
GVESMSESKA QGLGYRPIRR GAPRPSSHKH FDINEHLPWM IVLLLLLVLV
360 370 380 390 400
VIVVCSVKRS SRVLKKGPRQ DPSSIMEKAI HKKPSSPAQT KERWIYYSNG
410 420 430 440 450
QGVDILKLVA AQIGSQWIDL YKSLASATER EVAAFSNGYT ADHERAYAAL
460 470 480 490 500
QHWTIRDSDA NLAKLINALH RQRRIDVVDK IRSVMEDNPQ VDLNKLMTAV
510 520 530 540 550
NVSHCLSPSH KPLESPGVAV EQSPMERSRG FFPDESEPLL RCDSTSSKDS
560 570 580 590 600
ALSRTGSFIT KEKKDTVLRQ VRLDPCDLQP IFDDMLHILN PDELHVIEEI
610 620 630
PMAEDKLDRL FEIAGVKSQE ASQTLLDSVY SHLPDLL
Length:637
Mass (Da):70,000
Last modified:December 7, 2004 - v1
Checksum:i4B6F42D04A95479E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511269 Genomic DNA. No translation available.
BX842240 Genomic DNA. No translation available.
CR385023 Genomic DNA. No translation available.
DQ812118 mRNA. Translation: ABG91568.1.
UniGeneiDr.108925.

Genome annotation databases

EnsembliENSDART00000037855; ENSDARP00000036002; ENSDARG00000001807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511269 Genomic DNA. No translation available.
BX842240 Genomic DNA. No translation available.
CR385023 Genomic DNA. No translation available.
DQ812118 mRNA. Translation: ABG91568.1.
UniGeneiDr.108925.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000037855; ENSDARP00000036002; ENSDARG00000001807.

Organism-specific databases

ZFINiZDB-GENE-030131-5971. tnfrsf21.

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
HOVERGENiHBG054218.
OMAiFSRPEHM.
OrthoDBiEOG091G03XW.

Gene expression databases

BgeeiENSDARG00000001807.

Family and domain databases

CDDicd08778. Death_TNFRSF21. 1 hit.
cd10583. TNFRSF21. 1 hit.
Gene3Di1.10.533.10. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR034037. TNFRSF21_death.
IPR034034. TNFRSF21_N.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
PRINTSiPR01971. TNFACTORR21.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TYN2_DANRE
AccessioniPrimary (citable) accession number: Q5TYN2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 15, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.