Q5TYM5 (FA72A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM72A

Alternative name(s):
Latent membrane protein 1-induced protein
Short name=LMP1-induced protein
Short name=LMPIP

Gene names

Name:	FAM72A
Synonyms:	UGENE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. Ref.4
Subunit structure	Interacts with UNG. Ref.3
Subcellular location	Cytoplasm. Mitochondrion. Note: A V5 epitope-tagged construct has been shown to localize to the nucleus (Ref.3). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (Ref.4). Ref.3 Ref.4
Tissue specificity	May be up-regulated in malignant colon cancers, compared to normal colon and colon adenomas. Expression is also elevated in other common cancer types, including breast, lung, uterus, and ovary. Ref.3
Induction	Up-regulated in peripheral blood mononuclear cells following Epstein-Barr virus (EBV) infection or following transfection with EBV LMP1 protein. Ref.4
Miscellaneous	Highly homologous to GCUD2 but localized to a distinct locus.
Sequence similarities	Belongs to the FAM72 family.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5TYM5-1)

Also known as: Ugene-p;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5TYM5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     11-51: RCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTN → S

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	Protein FAM72A		PRO_0000340256
Natural variations
	Alternative sequence	11 – 51	41	RCVSI…IPPTN → S in isoform 2.		VSP_034205
Experimental info
	Mutagenesis	125	1	W → R: Loss of UNG-binding. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Ugene-p) [UniParc]. Last modified December 7, 2004. Version 1. Checksum: EB55B1921DED9EBB	FASTA	149	16,619
	10 20 30 40 50 60 MSTNICSFKD RCVSILCCKF CKQVLSSRGM KAVLLADTEI DLFSTDIPPT NAVDFTGRCY 70 80 90 100 110 120 FTKICKCKLK DIACLKCGNI VGYHVIVPCS SCLLSCNNGH FWMFHSQAVY DINRLDSTGV 130 140 NVLLWGNLPE IEESTDEDVL NISAEECIR
	Isoform 2 [UniParc]. Checksum: 0672B138D822F6FD	FASTA	109	12,207
	10 20 30 40 50 60 MSTNICSFKD SAVDFTGRCY FTKICKCKLK DIACLKCGNI VGYHVIVPCS SCLLSCNNGH 70 80 90 100 FWMFHSQAVY DINRLDSTGV NVLLWGNLPE IEESTDEDVL NISAEECIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[3]	"Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase." Guo C., Zhang X., Fink S.P., Platzer P., Wilson K., Willson J.K., Wang Z., Markowitz S.D. Cancer Res. 68:6118-6126(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UNG, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF TRP-125.
[4]	"Functional interaction of Ugene and EBV infection mediates tumorigenic effects." Wang L.T., Lin C.S., Chai C.Y., Liu K.Y., Chen J.Y., Hsu S.H. Oncogene 30:2921-2932(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY EBV INFECTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR407567 Genomic DNA. Translation: CAH72365.1. CR407567 Genomic DNA. Translation: CAH72366.1. BC035696 mRNA. Translation: AAH35696.1. BC146978 mRNA. Translation: AAI46979.1. BC146992 mRNA. Translation: AAI46993.1.
IPI	IPI00329150. IPI00647785.
RefSeq	NP_001116640.1. NM_001123168.1.
UniGene	Hs.661924.
3D structure databases
ProteinModelPortal	Q5TYM5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000356096.
Polymorphism databases
DMDM	74746671.
Proteomic databases
PaxDb	Q5TYM5.
PRIDE	Q5TYM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341209; ENSP00000340661; ENSG00000196550. ENST00000367128; ENSP00000356096; ENSG00000196550. ENST00000583602; ENSP00000463023; ENSG00000263687. ENST00000584006; ENSP00000462095; ENSG00000263687.
GeneID	729533.
KEGG	hsa:729533.
UCSC	uc001hdr.4. human.
Organism-specific databases
CTD	729533.
GeneCards	GC01P206136.
HGNC	HGNC:24044. FAM72A.
HPA	HPA043271.
MIM	614710. gene.
neXtProt	NX_Q5TYM5.
PharmGKB	PA142671833.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42824.
HOGENOM	HOG000031184.
HOVERGEN	HBG055076.
OMA	CKPCLLS.
OrthoDB	EOG4QVCDB.
Gene expression databases
ArrayExpress	Q5TYM5.
Bgee	Q5TYM5.
Genevestigator	Q5TYM5.
Family and domain databases
InterPro	IPR026768. FAM72. [Graphical view]
PANTHER	PTHR31841. PTHR31841. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	FAM72A. human.
GenomeRNAi	729533.
NextBio	130571.
SOURCE	Search...

Entry information

Entry name

FA72A_HUMAN

Accession

Primary (citable) accession number: Q5TYM5
Secondary accession number(s): B2RV15, Q5TYM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.