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Protein
Submitted name:

AGAP012069-PA

Gene

AgaP_AGAP012069

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
AGAP012069-PAImported
Gene namesi
ORF Names:AgaP_AGAP012069Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 3L

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ5TMZ6.

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP012069-PA.

Structurei

3D structure databases

ProteinModelPortaliQ5TMZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 369309Calpain catalyticInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOGENOMiHOG000232036.
InParanoidiQ5TMZ6.
OMAiARYPREM.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ5TMZ6.

Family and domain databases

InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TMZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFISWWLGS AEDGSDHDRS SSSIASESDC RSNTDLDAFE NQPTVKDFQA
60 70 80 90 100
LRDRCLAEGT LFEDPEFPAN NFSIYHSNPP KKGEREFEWK RPGEIVPSPK
110 120 130 140 150
FVTEGFSRFD VRQGIIGNCW FISSCSALTS HQELFERVVP LDNGQFEADH
160 170 180 190 200
YAGLFHFRFW QYGQWVEVIV DDRLPVGKNN QLLFISSSEK DEFWGALLEK
210 220 230 240 250
AYAKLHGSYE ALDSGTGREG MVDLTGGITE FYQLKGNEPD DLFERLESNL
260 270 280 290 300
ARRSLITAGI NGNERERVQS VNLVPQHEYS VTKVTRLDAT LHMLDFGAGN
310 320 330 340 350
AVDVRLICVR NPWGRGEWSG AWGDHSLEWI MVRDEKMEEL NIVKEDGEFW
360 370 380 390 400
MNFEDFVHHF DDVSVCYQCP GDMGKELRAR YPREMVSEMG EWKRSATAGG
410 420 430 440 450
SDENSFWSNP QYVLKLAHHE GYEADSRISV TIGLMQKHHR AKGTSFLSLR
460 470 480 490 500
LLVFPIPNHV LTGNRFLPKS FFDNVIPVET EANFETTREV VGRYKLPPGR
510 520 530
YVVVPHTWKP QQEAEFMLRI FAEGSVTKLC YCAGDVIG
Length:538
Mass (Da):61,418
Last modified:January 9, 2007 - v2
Checksum:i8C7328F04B31AFD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008986 Genomic DNA. Translation: EAL38766.2.
RefSeqiXP_552135.2. XM_552135.2.

Genome annotation databases

EnsemblMetazoaiAGAP012069-RA; AGAP012069-PA; AGAP012069.
GeneIDi3291503.
KEGGiaga:AgaP_AGAP012069.
VectorBaseiAGAP012069. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008986 Genomic DNA. Translation: EAL38766.2.
RefSeqiXP_552135.2. XM_552135.2.

3D structure databases

ProteinModelPortaliQ5TMZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP012069-PA.

Proteomic databases

PaxDbiQ5TMZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP012069-RA; AGAP012069-PA; AGAP012069.
GeneIDi3291503.
KEGGiaga:AgaP_AGAP012069.
VectorBaseiAGAP012069. Anopheles gambiae.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOGENOMiHOG000232036.
InParanoidiQ5TMZ6.
OMAiARYPREM.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ5TMZ6.

Family and domain databases

InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PESTImported.

Entry informationi

Entry nameiQ5TMZ6_ANOGA
AccessioniPrimary (citable) accession number: Q5TMZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.