Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phostensin

Gene

PPP1R18

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May target protein phosphatase 1 to F-actin cytoskeleton.By similarity

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phostensin
Alternative name(s):
Protein phosphatase 1 F-actin cytoskeleton-targeting subunit
Protein phosphatase 1 regulatory subunit 18
Gene namesi
Name:PPP1R18
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508081 – 613PhostensinAdd BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei175PhosphoserineBy similarity1
Modified residuei195PhosphoserineBy similarity1
Modified residuei199PhosphothreonineBy similarity1
Modified residuei224PhosphoserineBy similarity1
Modified residuei368PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei457N6-acetyllysineBy similarity1
Modified residuei490PhosphoserineBy similarity1
Modified residuei530PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Interacts with Protein phosphatase 1 (PP1).By similarity

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 103Poly-Gln8

Phylogenomic databases

eggNOGiENOG410IJQY. Eukaryota.
ENOG410ZUB8. LUCA.
HOVERGENiHBG080180.
InParanoidiQ5TM66.
KOiK17559.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TM66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIPDWKLQ LLARRRQEEA SVRGREKAER ERLSQMPAWK RGLLERRRAK
60 70 80 90 100
LGLSPGEPSP VPGTAEAGPP DPDESSVLLE AIGPVHQNRF IRQERQQQQQ
110 120 130 140 150
QQQRSEELLA ERKPVPLEAR ERRPSPGEMR DQSPKGRESR EERLSPRETR
160 170 180 190 200
ERRLGIGGAQ ESSLRPLEAR DWRQSPGEVG DRSSRLSEPW KWRLSPGETP
210 220 230 240 250
ERSLRLAESR EQSPRRKEVE SRLSPGESAY QKLGLTEAHK WRPDSRESQE
260 270 280 290 300
QSLVQLEATE WRLRSGEERQ GYSEKCGRKE EWPVPGVAPE ETTELSETLT
310 320 330 340 350
REAQGSSSTG MEAAEQRPVE DGERGMKPAE GWKWTLNSGK AREWTPRDIE
360 370 380 390 400
AQTQKPEPSE SAEKRLESPS VEAGEGEAEK EEAGAQGRPL RALQNCCSVP
410 420 430 440 450
SPLPPEDAGT GGLRQQEEEA VELQPPPPAP LSPPPPAPTA PQPPGDPLMS
460 470 480 490 500
RLFYGVKAGP GVGAPRRSGH TFTVNPRRSV PPTTPATPTS PATADAAVPG
510 520 530 540 550
AGKKRYPTAE EILVLGGYLR LSRSCLAKGS PERHHKQLKI SFSETALETT
560 570 580 590 600
YQYPSESSVL EELGPEPEVP SAPNPPAAQP DDEEDEEELL LLQPELQGGL
610
RTKALIVDES CRR
Length:613
Mass (Da):67,999
Last modified:December 21, 2004 - v1
Checksum:iAD54CFC5CE6DB6C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA. Translation: BAD69760.1.
RefSeqiNP_001098634.1. NM_001105164.1.
XP_014991336.1. XM_015135850.1.
UniGeneiMmu.12119.

Genome annotation databases

GeneIDi712176.
KEGGimcc:712176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA. Translation: BAD69760.1.
RefSeqiNP_001098634.1. NM_001105164.1.
XP_014991336.1. XM_015135850.1.
UniGeneiMmu.12119.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi712176.
KEGGimcc:712176.

Organism-specific databases

CTDi170954.

Phylogenomic databases

eggNOGiENOG410IJQY. Eukaryota.
ENOG410ZUB8. LUCA.
HOVERGENiHBG080180.
InParanoidiQ5TM66.
KOiK17559.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR18_MACMU
AccessioniPrimary (citable) accession number: Q5TM66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.