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Q5TM57

- RPP21_MACMU

UniProt

Q5TM57 - RPP21_MACMU

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Protein
Ribonuclease P protein subunit p21
Gene
RPP21
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Zinc By similarity
Metal bindingi65 – 651Zinc By similarity
Metal bindingi92 – 921Zinc By similarity
Metal bindingi95 – 951Zinc By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p21 (EC:3.1.26.5)
Short name:
RNaseP protein p21
Gene namesi
Name:RPP21
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 154153Ribonuclease P protein subunit p21
PRO_0000236682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5TM57.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG055987.
KOiK03540.

Family and domain databases

InterProiIPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5TM57-1 [UniParc]FASTAAdd to Basket

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MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCH TERTIAKRLV    50
LRRDPSVKRT LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR 100
FLNDPGHLLW GDRPEAQLGN QADSKPLQPL PNTAHSISDH LPEEKMQIQG 150
SSDQ 154
Length:154
Mass (Da):17,565
Last modified:December 21, 2004 - v1
Checksum:i49B3E9F2E88509EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB128049 Genomic DNA. Translation: BAD69769.1.
RefSeqiNP_001040603.1. NM_001047138.1.
UniGeneiMmu.10856.

Genome annotation databases

GeneIDi713056.
KEGGimcc:713056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB128049 Genomic DNA. Translation: BAD69769.1 .
RefSeqi NP_001040603.1. NM_001047138.1.
UniGenei Mmu.10856.

3D structure databases

ProteinModelPortali Q5TM57.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 713056.
KEGGi mcc:713056.

Organism-specific databases

CTDi 79897.

Phylogenomic databases

HOVERGENi HBG055987.
KOi K03540.

Miscellaneous databases

NextBioi 19980212.

Family and domain databases

InterProi IPR007175. Rpr2.
[Graphical view ]
PANTHERi PTHR14742. PTHR14742. 1 hit.
Pfami PF04032. Rpr2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complex."
    Kulski J.K., Anzai T., Shiina T., Inoko H.
    Mol. Biol. Evol. 21:2079-2091(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRPP21_MACMU
AccessioniPrimary (citable) accession number: Q5TM57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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