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Q5TM57

- RPP21_MACMU

UniProt

Q5TM57 - RPP21_MACMU

Protein

Ribonuclease P protein subunit p21

Gene

RPP21

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621ZincBy similarity
    Metal bindingi65 – 651ZincBy similarity
    Metal bindingi92 – 921ZincBy similarity
    Metal bindingi95 – 951ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p21 (EC:3.1.26.5)
    Short name:
    RNaseP protein p21
    Gene namesi
    Name:RPP21
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 154153Ribonuclease P protein subunit p21PRO_0000236682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TM57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG055987.
    KOiK03540.

    Family and domain databases

    InterProiIPR007175. Rpr2.
    [Graphical view]
    PANTHERiPTHR14742. PTHR14742. 1 hit.
    PfamiPF04032. Rpr2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5TM57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCH TERTIAKRLV    50
    LRRDPSVKRT LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR 100
    FLNDPGHLLW GDRPEAQLGN QADSKPLQPL PNTAHSISDH LPEEKMQIQG 150
    SSDQ 154
    Length:154
    Mass (Da):17,565
    Last modified:December 21, 2004 - v1
    Checksum:i49B3E9F2E88509EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB128049 Genomic DNA. Translation: BAD69769.1.
    RefSeqiNP_001040603.1. NM_001047138.1.
    UniGeneiMmu.10856.

    Genome annotation databases

    GeneIDi713056.
    KEGGimcc:713056.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB128049 Genomic DNA. Translation: BAD69769.1 .
    RefSeqi NP_001040603.1. NM_001047138.1.
    UniGenei Mmu.10856.

    3D structure databases

    ProteinModelPortali Q5TM57.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 713056.
    KEGGi mcc:713056.

    Organism-specific databases

    CTDi 79897.

    Phylogenomic databases

    HOVERGENi HBG055987.
    KOi K03540.

    Miscellaneous databases

    NextBioi 19980212.

    Family and domain databases

    InterProi IPR007175. Rpr2.
    [Graphical view ]
    PANTHERi PTHR14742. PTHR14742. 1 hit.
    Pfami PF04032. Rpr2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complex."
      Kulski J.K., Anzai T., Shiina T., Inoko H.
      Mol. Biol. Evol. 21:2079-2091(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRPP21_MACMU
    AccessioniPrimary (citable) accession number: Q5TM57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3