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Q5TM57 (RPP21_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit p21

Short name=RNaseP protein p21
EC=3.1.26.5
Gene names
Name:RPP21
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40 By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 4 family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentNucleus
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 154153Ribonuclease P protein subunit p21
PRO_0000236682

Sites

Metal binding621Zinc By similarity
Metal binding651Zinc By similarity
Metal binding921Zinc By similarity
Metal binding951Zinc By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5TM57 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 49B3E9F2E88509EB

FASTA15417,565
        10         20         30         40         50         60 
MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCH TERTIAKRLV LRRDPSVKRT 

        70         80         90        100        110        120 
LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR FLNDPGHLLW GDRPEAQLGN 

       130        140        150 
QADSKPLQPL PNTAHSISDH LPEEKMQIQG SSDQ 

« Hide

References

[1]"Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complex."
Kulski J.K., Anzai T., Shiina T., Inoko H.
Mol. Biol. Evol. 21:2079-2091(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB128049 Genomic DNA. Translation: BAD69769.1.
RefSeqNP_001040603.1. NM_001047138.1.
UniGeneMmu.10856.

3D structure databases

ProteinModelPortalQ5TM57.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID713056.
KEGGmcc:713056.

Organism-specific databases

CTD79897.

Phylogenomic databases

HOVERGENHBG055987.
KOK03540.

Family and domain databases

InterProIPR007175. Rpr2.
[Graphical view]
PANTHERPTHR14742. PTHR14742. 1 hit.
PfamPF04032. Rpr2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19980212.

Entry information

Entry nameRPP21_MACMU
AccessionPrimary (citable) accession number: Q5TM57
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families