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Protein

Corneodesmosin

Gene

CDSN

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Important for the epidermal barrier integrity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Corneodesmosin
Gene namesi
Name:CDSN
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

  • Secreted

  • Note: Found in corneodesmosomes, the intercellular structures that are involved in desquamation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 534502CorneodesmosinPRO_0000020913Add
BLAST

Interactioni

GO - Molecular functioni

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 469408Ser-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IENZ. Eukaryota.
ENOG41118PZ. LUCA.
HOGENOMiHOG000168434.
HOVERGENiHBG081074.
InParanoidiQ5TM45.

Family and domain databases

InterProiIPR026087. Corneodesmosin.
[Graphical view]
PANTHERiPTHR23207. PTHR23207. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5TM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSRAPWMG RVGGRGMMAL LLAGLLLPGT LAKSIGTFSD PCKDPTRITS
60 70 80 90 100
PNDPCLTGKG GSSGFSSYSG SSGSGSSISS ASGSGGGSSG SSVAQGGSAG
110 120 130 140 150
SFKPGTGYSQ VSYSSGSGSS LQGASSSSQL GGSGSQPGSS GSQPGSSGSH
160 170 180 190 200
SGSSGSNTGS SSSHSSSSST FQFSSSSSQV GSGSALPTSD NAYRGILNPS
210 220 230 240 250
QLGQSSSFSQ TSGQRVSSNQ RPCSSDIPDS PCSGGPIISH SGPYIPSSHS
260 270 280 290 300
VSGGQRPVVV VVEQHGSGGP GVVQGLPCSN GGLPGKPCPP ITSVDKSYGG
310 320 330 340 350
YEVVGGSSDS YLVPGMTYSK GKIYPVGYFT KDNPVKGSPG VPSFAAGPPI
360 370 380 390 400
SEGKYFSSNP IIPSQSGASS VIAFQPVGTG GVQLCGGGST GSKGPCSPFS
410 420 430 440 450
SRVHSSSSIS SSSGSPYHPC GSTSQSPCSP PGTGSFSSSS SSQSSGKIIL
460 470 480 490 500
QPCGSKSSSS GHPCMSVSSL TLTGDPDGSP HPDPSAGAKP CGSGSAGKIP
510 520 530
CRSIRDILAQ VKPLGPQLAD PEVFLPQGEL LDSP
Length:534
Mass (Da):51,983
Last modified:December 21, 2004 - v1
Checksum:iCB6A9DF256C32874
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA. Translation: BAD69749.1.
RefSeqiNP_001098639.1. NM_001105169.1.
UniGeneiMmu.17307.

Genome annotation databases

GeneIDi714553.
KEGGimcc:714553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA. Translation: BAD69749.1.
RefSeqiNP_001098639.1. NM_001105169.1.
UniGeneiMmu.17307.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi714553.
KEGGimcc:714553.

Organism-specific databases

CTDi1041.

Phylogenomic databases

eggNOGiENOG410IENZ. Eukaryota.
ENOG41118PZ. LUCA.
HOGENOMiHOG000168434.
HOVERGENiHBG081074.
InParanoidiQ5TM45.

Family and domain databases

InterProiIPR026087. Corneodesmosin.
[Graphical view]
PANTHERiPTHR23207. PTHR23207. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complex."
    Kulski J.K., Anzai T., Shiina T., Inoko H.
    Mol. Biol. Evol. 21:2079-2091(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCDSN_MACMU
AccessioniPrimary (citable) accession number: Q5TM45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.