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Protein

Allograft inflammatory factor 1

Gene

AIF1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi58 – 691PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1052PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1
Short name:
AIF-1
Gene namesi
Name:AIF1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projectionruffle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cell projectionphagocytic cup By similarity

  • Note: Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000738662 – 147Allograft inflammatory factor 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei11N6-acetyllysineBy similarity1
Modified residuei39PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000005296.
ExpressionAtlasiQ5TM25. differential.

Interactioni

Subunit structurei

Homodimer (Potential). Monomer. Interacts with LCP1 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000007001.

Structurei

3D structure databases

ProteinModelPortaliQ5TM25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 115EF-hand 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCUI. Eukaryota.
ENOG411206J. LUCA.
GeneTreeiENSGT00390000013846.
HOGENOMiHOG000231928.
HOVERGENiHBG004002.
InParanoidiQ5TM25.
KOiK18617.
OMAiAFKKKYM.
OrthoDBiEOG091G0ZI9.
TreeFamiTF320736.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5TM25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLLSKLEGF
60 70 80 90 100
KEKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET
110 120 130 140
FSYPDFLRMM LGKRSAILKM ILMYEEKARE KEKPTGPPAK KAISELP
Length:147
Mass (Da):16,719
Last modified:December 21, 2004 - v1
Checksum:i70B2179D24C6E29E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA. Translation: BAD69720.1.
RefSeqiNP_001040583.1. NM_001047118.1.
UniGeneiMmu.3528.

Genome annotation databases

EnsembliENSMMUT00000075966; ENSMMUP00000042853; ENSMMUG00000039582.
GeneIDi574115.
KEGGimcc:574115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA. Translation: BAD69720.1.
RefSeqiNP_001040583.1. NM_001047118.1.
UniGeneiMmu.3528.

3D structure databases

ProteinModelPortaliQ5TM25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000007001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000075966; ENSMMUP00000042853; ENSMMUG00000039582.
GeneIDi574115.
KEGGimcc:574115.

Organism-specific databases

CTDi199.

Phylogenomic databases

eggNOGiENOG410KCUI. Eukaryota.
ENOG411206J. LUCA.
GeneTreeiENSGT00390000013846.
HOGENOMiHOG000231928.
HOVERGENiHBG004002.
InParanoidiQ5TM25.
KOiK18617.
OMAiAFKKKYM.
OrthoDBiEOG091G0ZI9.
TreeFamiTF320736.

Gene expression databases

BgeeiENSMMUG00000005296.
ExpressionAtlasiQ5TM25. differential.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIF1_MACMU
AccessioniPrimary (citable) accession number: Q5TM25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.