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Protein

Lymphotoxin-beta

Gene

LTB

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-beta
Short name:
LT-beta
Alternative name(s):
Tumor necrosis factor C
Short name:
TNF-C
Tumor necrosis factor ligand superfamily member 3
Gene namesi
Name:LTB
Synonyms:TNFC, TNFSF3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST30
Topological domaini49 – 244ExtracellularSequence analysisAdd BLAST196

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854881 – 244Lymphotoxin-betaAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000008849.
ExpressionAtlasiQ5TM22. baseline.

Interactioni

Subunit structurei

Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000011600.

Structurei

3D structure databases

ProteinModelPortaliQ5TM22.
SMRiQ5TM22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJP9. Eukaryota.
ENOG410ZHBF. LUCA.
GeneTreeiENSGT00390000007066.
HOGENOMiHOG000273916.
HOVERGENiHBG000209.
InParanoidiQ5TM22.
KOiK03157.
OMAiYCHVGYR.
OrthoDBiEOG091G0J9M.
TreeFamiTF337780.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR006053. TNF.
IPR002961. TNF_C.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
PRINTSiPR01234. TNECROSISFCT.
PR01237. TNFC.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TM22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD
60 70 80 90 100
QGGLVTDTAD PGAQAQQGLG FQKLPEEEPE ADLSPGLPAA HLIGAPLKGQ
110 120 130 140 150
GLGWEATKEQ AFLTSGTQFS DADGLALPQD GLYYLYCLVG YRGRAPPGGA
160 170 180 190 200
EPRGRSVTLR SSLYRAGGAY GPGTPELLLE GAETVTPVLD PAGRQGYGPL
210 220 230 240
WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA VMVG
Length:244
Mass (Da):25,259
Last modified:December 21, 2004 - v1
Checksum:i46AA5DEEE255B6C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128049 Genomic DNA. Translation: BAD69723.1.
RefSeqiNP_001040615.1. NM_001047150.1.
UniGeneiMmu.10858.

Genome annotation databases

EnsembliENSMMUT00000012368; ENSMMUP00000011600; ENSMMUG00000008849.
GeneIDi715518.
KEGGimcc:715518.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTNFC_MACMU
AccessioniPrimary (citable) accession number: Q5TM22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families