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Q5TLG6

- Q5TLG6_9CNID

UniProt

Q5TLG6 - Q5TLG6_9CNID

Protein
Submitted name:

Fluorescent protein Dronpa

Gene

Dronpa

Organism
Echinophyllia sp. SC22
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi134 – 1341Potassium; via carbonyl oxygenImported
    Metal bindingi136 – 1361Potassium; via carbonyl oxygenImported
    Metal bindingi164 – 1641PotassiumImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. bioluminescence Source: InterPro
    2. generation of precursor metabolites and energy Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fluorescent protein DronpaImported
    Gene namesi
    Name:DronpaImported
    OrganismiEchinophyllia sp. SC22Imported
    Taxonomic identifieri301887 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaScleractiniaFaviinaLobophylliidaeEchinophyllia

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-46137N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GX0X-ray1.90A/B/C/D2-224[»]
    2GX2X-ray1.80A/B/C/D/E/F/G/H/I/J/K/L2-224[»]
    2IE2X-ray1.70A/B/C/D/E/F1-224[»]
    2IOVX-ray1.80A/B/C/D1-224[»]
    2POXX-ray1.95A/B/C/D1-224[»]
    2Z1OX-ray1.75A/B/C/D1-224[»]
    2Z6XX-ray2.30A/B/C/D/E/F/G/H1-224[»]
    2Z6YX-ray2.00A/B/C/D1-224[»]
    2Z6ZX-ray1.80A/B/C/D/E/F1-224[»]
    3ZUFX-ray2.20A/B/C/D/E/F142-218[»]
    A/B/C/D/E/F2-93[»]
    A/B/C/D/E/F95-140[»]
    3ZUJX-ray2.34A/B/C/D/E/F142-217[»]
    A/B/C/D/E/F2-93[»]
    A/B/C/D/E/F95-140[»]
    3ZULX-ray2.30A/B/C/D/E/F142-224[»]
    A/B/C/D/E/F2-93[»]
    A/B/C/D/E/F95-140[»]
    4EMQX-ray1.95A/B/C/D/E/F1-224[»]
    4HQ8X-ray1.95A/B/C/D/E/F1-101[»]
    A/B/C/D/E/F103-224[»]
    4HQ9X-ray2.07A/B/C/D/E/F1-101[»]
    A/B/C/D/E/F103-224[»]
    4HQCX-ray2.05A/B/C/D/E/F1-101[»]
    A/B/C/D/E/F103-224[»]
    4IZNX-ray2.15A/B/C/D/E/F/G/H/I/J/K/L1-101[»]
    A/B/C/D/E/F/G/H/I/J/K/L103-224[»]
    ProteinModelPortaliQ5TLG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5TLG6.

    Family & Domainsi

    Family and domain databases

    Gene3Di2.40.155.10. 1 hit.
    InterProiIPR009017. GFP.
    IPR011584. GFP-related.
    IPR023413. GFP_like.
    IPR000786. Green_fluorescent_prot.
    [Graphical view]
    PfamiPF01353. GFP. 1 hit.
    [Graphical view]
    PRINTSiPR01229. GFLUORESCENT.
    SUPFAMiSSF54511. SSF54511. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5TLG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVIKPDMKI KLRMEGAVNG HPFAIEGVGL GKPFEGKQSM DLKVKEGGPL    50
    PFAYDILTTV FCYGNRVFAK YPENIVDYFK QSFPEGYSWE RSMNYEDGGI 100
    CNATNDITLD GDCYIYEIRF DGVNFPANGP VMQKRTVKWE PSTEKLYVRD 150
    GVLKGDVNMA LSLEGGGHYR CDFKTTYKAK KVVQLPDYHF VDHHIEIKSH 200
    DKDYSNVNLH EHAEAHSELP RQAK 224
    Length:224
    Mass (Da):25,481
    Last modified:December 21, 2004 - v1
    Checksum:i9091A477C9A99D98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB180726 Genomic DNA. Translation: BAD72874.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB180726 Genomic DNA. Translation: BAD72874.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GX0 X-ray 1.90 A/B/C/D 2-224 [» ]
    2GX2 X-ray 1.80 A/B/C/D/E/F/G/H/I/J/K/L 2-224 [» ]
    2IE2 X-ray 1.70 A/B/C/D/E/F 1-224 [» ]
    2IOV X-ray 1.80 A/B/C/D 1-224 [» ]
    2POX X-ray 1.95 A/B/C/D 1-224 [» ]
    2Z1O X-ray 1.75 A/B/C/D 1-224 [» ]
    2Z6X X-ray 2.30 A/B/C/D/E/F/G/H 1-224 [» ]
    2Z6Y X-ray 2.00 A/B/C/D 1-224 [» ]
    2Z6Z X-ray 1.80 A/B/C/D/E/F 1-224 [» ]
    3ZUF X-ray 2.20 A/B/C/D/E/F 142-218 [» ]
    A/B/C/D/E/F 2-93 [» ]
    A/B/C/D/E/F 95-140 [» ]
    3ZUJ X-ray 2.34 A/B/C/D/E/F 142-217 [» ]
    A/B/C/D/E/F 2-93 [» ]
    A/B/C/D/E/F 95-140 [» ]
    3ZUL X-ray 2.30 A/B/C/D/E/F 142-224 [» ]
    A/B/C/D/E/F 2-93 [» ]
    A/B/C/D/E/F 95-140 [» ]
    4EMQ X-ray 1.95 A/B/C/D/E/F 1-224 [» ]
    4HQ8 X-ray 1.95 A/B/C/D/E/F 1-101 [» ]
    A/B/C/D/E/F 103-224 [» ]
    4HQ9 X-ray 2.07 A/B/C/D/E/F 1-101 [» ]
    A/B/C/D/E/F 103-224 [» ]
    4HQC X-ray 2.05 A/B/C/D/E/F 1-101 [» ]
    A/B/C/D/E/F 103-224 [» ]
    4IZN X-ray 2.15 A/B/C/D/E/F/G/H/I/J/K/L 1-101 [» ]
    A/B/C/D/E/F/G/H/I/J/K/L 103-224 [» ]
    ProteinModelPortali Q5TLG6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46137N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q5TLG6.

    Family and domain databases

    Gene3Di 2.40.155.10. 1 hit.
    InterProi IPR009017. GFP.
    IPR011584. GFP-related.
    IPR023413. GFP_like.
    IPR000786. Green_fluorescent_prot.
    [Graphical view ]
    Pfami PF01353. GFP. 1 hit.
    [Graphical view ]
    PRINTSi PR01229. GFLUORESCENT.
    SUPFAMi SSF54511. SSF54511. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting."
      Ando R., Mizuno H., Miyawaki A.
      Science 306:1370-1373(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SC22Imported.
    2. "The 1.7 A crystal structure of Dronpa: a photoswitchable green fluorescent protein."
      Wilmann P.G., Turcic K., Battad J.M., Wilce M.C., Devenish R.J., Prescott M., Rossjohn J.
      J. Mol. Biol. 364:213-224(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
    3. "Structural characterization of the photoswitchable fluorescent protein Dronpa-C62S."
      Nam K.H., Kwon O.Y., Sugiyama K., Lee W.H., Kim Y.K., Song H.K., Kim E.E., Park S.Y., Jeon H., Hwang K.Y.
      Biochem. Biophys. Res. Commun. 354:962-967(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-224.
    4. "1.8 A bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants."
      Stiel A.C., Trowitzsch S., Weber G., Andresen M., Eggeling C., Hell S.W., Jakobs S., Wahl M.C.
      Biochem. J. 402:35-42(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
    5. Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
    6. "Light-dependent regulation of structural flexibility in a photochromic fluorescent protein."
      Mizuno H., Mal T.K., Walchli M., Kikuchi A., Fukano T., Ando R., Jeyakanthan J., Taka J., Shiro Y., Ikura M., Miyawaki A.
      Proc. Natl. Acad. Sci. U.S.A. 105:9227-9232(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).
    7. "Low-temperature chromophore isomerization reveals the photoswitching mechanism of the fluorescent protein Padron."
      Faro A.R., Carpentier P., Jonasson G., Pompidor G., Arcizet D., Demachy I., Bourgeois D.
      J. Am. Chem. Soc. 133:16362-16365(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 142-218; 2-93 AND 95-140.
    8. "Structural basis for the influence of a single mutation K145N on the oligomerization and photoswitching rate of Dronpa."
      Nguyen Bich N., Moeyaert B., Van Hecke K., Dedecker P., Mizuno H., Hofkens J., Van Meervelt L.
      Acta Crystallogr. D 68:1653-1659(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
    9. "Green-to-red photoconvertible Dronpa mutant for multimodal super-resolution fluorescence microscopy."
      Moeyaert B., Nguyen Bich N., De Zitter E., Rocha S., Clays K., Mizuno H., van Meervelt L., Hofkens J., Dedecker P.
      ACS Nano 8:1664-1673(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-101 AND 103-224.

    Entry informationi

    Entry nameiQ5TLG6_9CNID
    AccessioniPrimary (citable) accession number: Q5TLG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3