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Q5TLG6

- Q5TLG6_9CNID

UniProt

Q5TLG6 - Q5TLG6_9CNID

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Protein
Submitted name: Fluorescent protein Dronpa
Gene
Dronpa
Organism
Echinophyllia sp. SC22
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Potassium; via carbonyl oxygenImported
Metal bindingi136 – 1361Potassium; via carbonyl oxygenImported
Metal bindingi164 – 1641PotassiumImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. bioluminescence Source: InterPro
  2. generation of precursor metabolites and energy Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, PotassiumImported

Names & Taxonomyi

Protein namesi
Submitted name:
Fluorescent protein DronpaImported
Gene namesi
Name:DronpaImported
OrganismiEchinophyllia sp. SC22Imported
Taxonomic identifieri301887 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaScleractiniaFaviinaLobophylliidaeEchinophyllia

Interactioni

Protein-protein interaction databases

DIPiDIP-46137N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GX0X-ray1.90A/B/C/D2-224[»]
2GX2X-ray1.80A/B/C/D/E/F/G/H/I/J/K/L2-224[»]
2IE2X-ray1.70A/B/C/D/E/F1-224[»]
2IOVX-ray1.80A/B/C/D1-224[»]
2POXX-ray1.95A/B/C/D1-224[»]
2Z1OX-ray1.75A/B/C/D1-224[»]
2Z6XX-ray2.30A/B/C/D/E/F/G/H1-224[»]
2Z6YX-ray2.00A/B/C/D1-224[»]
2Z6ZX-ray1.80A/B/C/D/E/F1-224[»]
3ZUFX-ray2.20A/B/C/D/E/F142-218[»]
A/B/C/D/E/F2-93[»]
A/B/C/D/E/F95-140[»]
3ZUJX-ray2.34A/B/C/D/E/F142-217[»]
A/B/C/D/E/F2-93[»]
A/B/C/D/E/F95-140[»]
3ZULX-ray2.30A/B/C/D/E/F142-224[»]
A/B/C/D/E/F2-93[»]
A/B/C/D/E/F95-140[»]
4EMQX-ray1.95A/B/C/D/E/F1-224[»]
4HQ8X-ray1.95A/B/C/D/E/F1-101[»]
A/B/C/D/E/F103-224[»]
4HQ9X-ray2.07A/B/C/D/E/F1-101[»]
A/B/C/D/E/F103-224[»]
4HQCX-ray2.05A/B/C/D/E/F1-101[»]
A/B/C/D/E/F103-224[»]
4IZNX-ray2.15A/B/C/D/E/F/G/H/I/J/K/L1-101[»]
A/B/C/D/E/F/G/H/I/J/K/L103-224[»]
ProteinModelPortaliQ5TLG6.

Miscellaneous databases

EvolutionaryTraceiQ5TLG6.

Family & Domainsi

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
InterProiIPR009017. GFP.
IPR011584. GFP-related.
IPR023413. GFP_like.
IPR000786. Green_fluorescent_prot.
[Graphical view]
PfamiPF01353. GFP. 1 hit.
[Graphical view]
PRINTSiPR01229. GFLUORESCENT.
SUPFAMiSSF54511. SSF54511. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TLG6-1 [UniParc]FASTAAdd to Basket

« Hide

MSVIKPDMKI KLRMEGAVNG HPFAIEGVGL GKPFEGKQSM DLKVKEGGPL    50
PFAYDILTTV FCYGNRVFAK YPENIVDYFK QSFPEGYSWE RSMNYEDGGI 100
CNATNDITLD GDCYIYEIRF DGVNFPANGP VMQKRTVKWE PSTEKLYVRD 150
GVLKGDVNMA LSLEGGGHYR CDFKTTYKAK KVVQLPDYHF VDHHIEIKSH 200
DKDYSNVNLH EHAEAHSELP RQAK 224
Length:224
Mass (Da):25,481
Last modified:December 21, 2004 - v1
Checksum:i9091A477C9A99D98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB180726 Genomic DNA. Translation: BAD72874.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB180726 Genomic DNA. Translation: BAD72874.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GX0 X-ray 1.90 A/B/C/D 2-224 [» ]
2GX2 X-ray 1.80 A/B/C/D/E/F/G/H/I/J/K/L 2-224 [» ]
2IE2 X-ray 1.70 A/B/C/D/E/F 1-224 [» ]
2IOV X-ray 1.80 A/B/C/D 1-224 [» ]
2POX X-ray 1.95 A/B/C/D 1-224 [» ]
2Z1O X-ray 1.75 A/B/C/D 1-224 [» ]
2Z6X X-ray 2.30 A/B/C/D/E/F/G/H 1-224 [» ]
2Z6Y X-ray 2.00 A/B/C/D 1-224 [» ]
2Z6Z X-ray 1.80 A/B/C/D/E/F 1-224 [» ]
3ZUF X-ray 2.20 A/B/C/D/E/F 142-218 [» ]
A/B/C/D/E/F 2-93 [» ]
A/B/C/D/E/F 95-140 [» ]
3ZUJ X-ray 2.34 A/B/C/D/E/F 142-217 [» ]
A/B/C/D/E/F 2-93 [» ]
A/B/C/D/E/F 95-140 [» ]
3ZUL X-ray 2.30 A/B/C/D/E/F 142-224 [» ]
A/B/C/D/E/F 2-93 [» ]
A/B/C/D/E/F 95-140 [» ]
4EMQ X-ray 1.95 A/B/C/D/E/F 1-224 [» ]
4HQ8 X-ray 1.95 A/B/C/D/E/F 1-101 [» ]
A/B/C/D/E/F 103-224 [» ]
4HQ9 X-ray 2.07 A/B/C/D/E/F 1-101 [» ]
A/B/C/D/E/F 103-224 [» ]
4HQC X-ray 2.05 A/B/C/D/E/F 1-101 [» ]
A/B/C/D/E/F 103-224 [» ]
4IZN X-ray 2.15 A/B/C/D/E/F/G/H/I/J/K/L 1-101 [» ]
A/B/C/D/E/F/G/H/I/J/K/L 103-224 [» ]
ProteinModelPortali Q5TLG6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46137N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q5TLG6.

Family and domain databases

Gene3Di 2.40.155.10. 1 hit.
InterProi IPR009017. GFP.
IPR011584. GFP-related.
IPR023413. GFP_like.
IPR000786. Green_fluorescent_prot.
[Graphical view ]
Pfami PF01353. GFP. 1 hit.
[Graphical view ]
PRINTSi PR01229. GFLUORESCENT.
SUPFAMi SSF54511. SSF54511. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting."
    Ando R., Mizuno H., Miyawaki A.
    Science 306:1370-1373(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SC22Imported.
  2. "The 1.7 A crystal structure of Dronpa: a photoswitchable green fluorescent protein."
    Wilmann P.G., Turcic K., Battad J.M., Wilce M.C., Devenish R.J., Prescott M., Rossjohn J.
    J. Mol. Biol. 364:213-224(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
  3. "Structural characterization of the photoswitchable fluorescent protein Dronpa-C62S."
    Nam K.H., Kwon O.Y., Sugiyama K., Lee W.H., Kim Y.K., Song H.K., Kim E.E., Park S.Y., Jeon H., Hwang K.Y.
    Biochem. Biophys. Res. Commun. 354:962-967(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-224.
  4. "1.8 A bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants."
    Stiel A.C., Trowitzsch S., Weber G., Andresen M., Eggeling C., Hell S.W., Jakobs S., Wahl M.C.
    Biochem. J. 402:35-42(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
  6. "Light-dependent regulation of structural flexibility in a photochromic fluorescent protein."
    Mizuno H., Mal T.K., Walchli M., Kikuchi A., Fukano T., Ando R., Jeyakanthan J., Taka J., Shiro Y., Ikura M., Miyawaki A.
    Proc. Natl. Acad. Sci. U.S.A. 105:9227-9232(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).
  7. "Low-temperature chromophore isomerization reveals the photoswitching mechanism of the fluorescent protein Padron."
    Faro A.R., Carpentier P., Jonasson G., Pompidor G., Arcizet D., Demachy I., Bourgeois D.
    J. Am. Chem. Soc. 133:16362-16365(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 142-218; 2-93 AND 95-140.
  8. "Structural basis for the influence of a single mutation K145N on the oligomerization and photoswitching rate of Dronpa."
    Nguyen Bich N., Moeyaert B., Van Hecke K., Dedecker P., Mizuno H., Hofkens J., Van Meervelt L.
    Acta Crystallogr. D 68:1653-1659(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
  9. "Green-to-red photoconvertible Dronpa mutant for multimodal super-resolution fluorescence microscopy."
    Moeyaert B., Nguyen Bich N., De Zitter E., Rocha S., Clays K., Mizuno H., van Meervelt L., Hofkens J., Dedecker P.
    ACS Nano 8:1664-1673(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-101 AND 103-224 IN COMPLEX WITH POTASSIUM.

Entry informationi

Entry nameiQ5TLG6_9CNID
AccessioniPrimary (citable) accession number: Q5TLG6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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