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Protein

Protein lin-9 homolog

Gene

LIN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.2 Publications

GO - Biological processi

Keywordsi

Biological processCell cycle, DNA synthesis

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SIGNORiQ5TKA1

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-9 homolog
Short name:
HuLin-9
Short name:
hLin-9
Alternative name(s):
Beta subunit-associated regulator of apoptosis
TUDOR gene similar protein
Type I interferon receptor beta chain-associated protein
pRB-associated protein
Gene namesi
Name:LIN9
Synonyms:BARA, TGS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183814.15
HGNCiHGNC:30830 LIN9
MIMi609375 gene
neXtProtiNX_Q5TKA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi286826
OpenTargetsiENSG00000183814
PharmGKBiPA134970771

Polymorphism and mutation databases

BioMutaiLIN9
DMDMi74708186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002495462 – 542Protein lin-9 homologAdd BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei65PhosphoserineCombined sources1
Modified residuei95PhosphoserineBy similarity1
Modified residuei96PhosphothreonineCombined sources1
Modified residuei304PhosphothreonineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5TKA1
MaxQBiQ5TKA1
PaxDbiQ5TKA1
PeptideAtlasiQ5TKA1
PRIDEiQ5TKA1

PTM databases

iPTMnetiQ5TKA1
PhosphoSitePlusiQ5TKA1

Expressioni

Tissue specificityi

Expressed in thymus and testis.1 Publication

Gene expression databases

BgeeiENSG00000183814
CleanExiHS_LIN9
ExpressionAtlasiQ5TKA1 baseline and differential
GenevisibleiQ5TKA1 HS

Organism-specific databases

HPAiHPA030241

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130420, 34 interactors
CORUMiQ5TKA1
IntActiQ5TKA1, 17 interactors
MINTiQ5TKA1
STRINGi9606.ENSP00000329102

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 296Sufficient for interaction with RB11 PublicationAdd BLAST295

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili354 – 413Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the lin-9 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1019 Eukaryota
ENOG410YA1T LUCA
GeneTreeiENSGT00390000003188
HOGENOMiHOG000007517
HOVERGENiHBG057743
InParanoidiQ5TKA1
KOiK21773
PhylomeDBiQ5TKA1
TreeFamiTF314315

Family and domain databases

InterProiView protein in InterPro
IPR033471 DIRP
IPR010561 LIN-9/ALY1
PANTHERiPTHR21689 PTHR21689, 1 hit
PfamiView protein in Pfam
PF06584 DIRP, 1 hit
SMARTiView protein in SMART
SM01135 DIRP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TKA1-1) [UniParc]FASTAAdd to basket
Also known as: Lin9-L, Long form

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDQLPDE SSSAKALVSL KEGSLSNTWN EKYSSLQKTP VWKGRNTSSA
60 70 80 90 100
VEMPFRNSKR SRLFSDEDDR QINTRSPKRN QRVAMVPQKF TATMSTPDKK
110 120 130 140 150
ASQKIGFRLR NLLKLPKAHK WCIYEWFYSN IDKPLFEGDN DFCVCLKESF
160 170 180 190 200
PNLKTRKLTR VEWGKIRRLM GKPRRCSSAF FEEERSALKQ KRQKIRLLQQ
210 220 230 240 250
RKVADVSQFK DLPDEIPLPL VIGTKVTARL RGVHDGLFTG QIDAVDTLNA
260 270 280 290 300
TYRVTFDRTG LGTHTIPDYE VLSNEPHETM PIAAFGQKQR PSRFFMTPPR
310 320 330 340 350
LHYTPPLQSP IIDNDPLLGQ SPWRSKISGS DTETLGGFPV EFLIQVTRLS
360 370 380 390 400
KILMIKKEHI KKLREMNTEA EKLKSYSMPI SIEFQRRYAT IVLELEQLNK
410 420 430 440 450
DLNKVLHKVQ QYCYELAPDQ GLQPADQPTD MRRRCEEEAQ EIVRHANSST
460 470 480 490 500
GQPCVENENL TDLISRLTAI LLQIKCLAEG GDLNSFEFKS LTDSLNDIKS
510 520 530 540
TIDASNISCF QNNVEIHVAH IQSGLSQMGN LHAFAANNTN RD
Length:542
Mass (Da):61,946
Last modified:December 21, 2004 - v1
Checksum:i1107865E6FF33037
GO
Isoform 2 (identifier: Q5TKA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHRGGQPLKKRRGSFKM

Show »
Length:558
Mass (Da):63,811
Checksum:i90ECE86266AF02CE
GO
Isoform 3 (identifier: Q5TKA1-3) [UniParc]FASTAAdd to basket
Also known as: Lin9-S, Short form

The sequence of this isoform differs from the canonical sequence as follows:
     54-88: Missing.

Show »
Length:507
Mass (Da):57,733
Checksum:iB657E9DD7A2882F0
GO

Sequence cautioni

The sequence AAH43444 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD97871 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436E → V in AAH43444 (PubMed:15489334).Curated1
Sequence conflicti508S → R in AAV41873 (PubMed:15538385).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0205091M → MHRGGQPLKKRRGSFKM in isoform 2. 1 Publication1
Alternative sequenceiVSP_02051054 – 88Missing in isoform 3. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY786184 mRNA Translation: AAV41873.1
AF190323 mRNA Translation: AAQ13710.1
AF190324 mRNA Translation: AAQ13711.1
AK126177 mRNA Translation: BAC86475.1
BX537869 mRNA Translation: CAD97871.1 Different initiation.
BC043444 mRNA Translation: AAH43444.1 Different initiation.
BC045625 mRNA Translation: AAH45625.1
CCDSiCCDS1553.1 [Q5TKA1-2]
RefSeqiNP_001257338.1, NM_001270409.1
NP_001257339.1, NM_001270410.1
NP_775106.2, NM_173083.3 [Q5TKA1-2]
UniGeneiHs.120817

Genome annotation databases

EnsembliENST00000328205; ENSP00000329102; ENSG00000183814 [Q5TKA1-2]
GeneIDi286826
KEGGihsa:286826
UCSCiuc001hqa.4 human [Q5TKA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLIN9_HUMAN
AccessioniPrimary (citable) accession number: Q5TKA1
Secondary accession number(s): Q5U5L8
, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health