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Protein

Zinc transporter SLC39A7

Gene

SLC39A7

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter SLC39A7
Alternative name(s):
Histidine-rich membrane protein Ke4
Solute carrier family 39 member 7
Zrt-, Irt-like protein 7
Short name:
ZIP7
Gene namesi
Name:SLC39A7Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136871 – 469Zinc transporter SLC39A7Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5TJF6.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001312.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 263His-richSequence analysisAdd BLAST236
Compositional biasi277 – 282Poly-GluSequence analysis6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
HOGENOMiHOG000185308.
HOVERGENiHBG001037.
InParanoidiQ5TJF6.
KOiK14713.

Family and domain databases

InterProiView protein in InterPro
IPR003689. ZIP.
PfamiView protein in Pfam
PF02535. Zip. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TJF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLGAPHW VAVGLLTWAA LGLLVAGHGG HGDLHEDLHE DFHGHSHRRS
60 70 80 90 100
HEDFHHGHSY AHGHGHTHES IWHGHTHGHE HGHAHEDLHH GHSHGQSHES
110 120 130 140 150
LYHRGHGHDH EHSHGGYGES GAPGIKQDLD TVTLWAYALG ATVLISAAPF
160 170 180 190 200
FVLFLIPVES NSPRHRSLLQ ILLSFASGGL LGDAFLHLIP HALEPHSHHP
210 220 230 240 250
LEQPGHGHSH SGQGPILSVG LWVLSGIVAF LVVEKFVRHV KGGHGHSHGH
260 270 280 290 300
GHTHGHTQGS HGHGTQKYPS KEKQSSEEEE KEANGSRKRK GGSTRLKDGP
310 320 330 340 350
LRPQNSEEEK TGSDLRVSGY LNLAADLAHN FTDGLAIGAS FRGGRGLGIL
360 370 380 390 400
TTMTVLLHEV PHEVGDFAIL VQSGCSKKQA MRLQLLTAIG ALAGTACALL
410 420 430 440 450
TEGGAVGSEV AGGTGSGWVL PFTAGGFIYV ATVSVLPELL REASPLQSLL
460
EVLGLLGGVV MMVLIAHLE
Length:469
Mass (Da):49,916
Last modified:December 21, 2004 - v1
Checksum:i8266CA42D94D4024
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ630366 Genomic DNA. Translation: CAI11432.1.
RefSeqiNP_001041565.1. NM_001048100.1.
UniGeneiCfa.18787.

Genome annotation databases

GeneIDi481736.
KEGGicfa:481736.

Similar proteinsi

Entry informationi

Entry nameiS39A7_CANLF
AccessioniPrimary (citable) accession number: Q5TJF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families