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Reviewed, UniProtKB/Swiss-Prot Q5TJF5 (DHB8_CANFA)

Last modified November 4, 2008. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Estradiol 17-beta-dehydrogenase 8
    EC=1.1.1.62
Alternative name(s):
    Testosterone 17-beta-dehydrogenase 8
    EC=1.1.1.63
    17-beta-hydroxysteroid dehydrogenase 8
      Short name=17-beta-HSD 8
Gene names
Name: HSD17B8
OrganismCanis familiaris (Dog)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Uses estradiol as its preferred substrate By similarity.

Catalytic activity

Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.

Testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH.

Pathway

Steroid biosynthesis; estrogen biosynthesis.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Estradiol 17-beta-dehydrogenase 8
PRO_0000054597

Regions

Nucleotide binding13 – 3725NAD By similarity

Sites

Active site1671Proton acceptor By similarity
Binding site1541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5TJF5-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 40AA25885DE5E197

FASTA25926,712
        10         20         30         40         50         60 
MASPLRLRSA LALVTGAGSG IGRAVSVRLA KEGATVAACD LDRAAACETV WLLGGQGSEK 

        70         80         90        100        110        120 
VAPGGAHTAF QADVSEAGAV RRLLEQVQAC FSRPPSVVVS CAGLTRDEFL LRMSEDDWDR 

       130        140        150        160        170        180 
VIAVNLKGIF LVTQAAAQAL VSSGCRGSII NISSIVGKVG NVGQTNYAAS KAGVIGLTQT 

       190        200        210        220        230        240 
AARELGRHGI RCNSVLPGFI TTPMTQKVPQ KVLDKVIGMI PMGHLGDPED VADAVTFLAS 

       250 
EDSGYITGAS VEVTGGLYM 

« Hide

References

[1]"Genomic sequence of the class II region of the canine MHC: comparison with the MHC of other mammalian species."
Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A., Ollier W.E.R., Binns M.M.
Genomics 85:48-59(2005) [PubMed: 15607421] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Doberman pinscher.

Cross-references

Sequence databases

AJ630366 Genomic DNA. Translation: CAI11433.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSCAFG00000000927. Canis familiaris. [Contig view]

Phylogenomic databases

HOVERGENQ5TJF5.

Family and domain databases

InterProIPR002198. DHase_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DHase.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Entry information

Entry nameDHB8_CANFA
AccessionPrimary (citable) accession number: Q5TJF5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 21, 2004
Last modified: November 4, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents