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Protein

Beta-1,3-galactosyltransferase 4

Gene

B3GALT4

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in GM1/GD1B/GA1 ganglioside biosynthesis.By similarity

Catalytic activityi

UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 4 (EC:2.4.1.62)
Short name:
Beta-1,3-GalTase 4
Short name:
Beta3Gal-T4
Short name:
Beta3GalT4
Short name:
GalT4
Short name:
b3Gal-T4
Alternative name(s):
Gal-T2
Ganglioside galactosyltransferase
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
Gene namesi
Name:B3GALT4
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Topological domaini30 – 383354LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Beta-1,3-galactosyltransferase 4PRO_0000219159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5TJE8.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000037824.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOVERGENiHBG050651.
InParanoidiQ5TJE8.
KOiK00715.
OMAiPFCSWLQ.
OrthoDBiEOG76MK8S.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TJE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSLFRRLL LAALLLVIIW TLFGPSGIGE ELLSLSLASL SPAPASPGPP
60 70 80 90 100
LALPRLLIPN EKACGGPGSP PFLLILVCTA PENLNQRNAI RASWGGLREA
110 120 130 140 150
QGFRVQILFL LGEPSLWHPT KEPHDIDLVR EAAAQGDILQ AAFRDSYRNL
160 170 180 190 200
TLKTLSGLNW ADKHCSMARY ILKTDDDVFV NVPELVSELI RRGGHWEQWE
210 220 230 240 250
KGKEPPRAVK AGDKEWEERP ILKSQPMPLL YLGRVHWRVH PSRTPGSKHQ
260 270 280 290 300
ISEEQWPPTW GPFPPYASGT GYVLSASAVQ LILKVASRAP PLPLEDVFVG
310 320 330 340 350
VSARRGGLTP THCVKLAGAT HYPLDRCCYG KFLLTSHKLD PWKMQEAWKL
360 370 380
VGGSDGERTA PFCSWLQEVL GILRCRVIAW LHS
Length:383
Mass (Da):42,465
Last modified:December 21, 2004 - v1
Checksum:i8CEBC3C3E3D3DAC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ630366 Genomic DNA. Translation: CAI11440.1.
RefSeqiNP_001074191.1. NM_001080722.1.
XP_005627127.1. XM_005627070.2.
XP_013973519.1. XM_014118044.1.
UniGeneiCfa.43935.

Genome annotation databases

EnsembliENSCAFT00000001474; ENSCAFP00000037824; ENSCAFG00000000952.
GeneIDi481737.
KEGGicfa:481737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ630366 Genomic DNA. Translation: CAI11440.1.
RefSeqiNP_001074191.1. NM_001080722.1.
XP_005627127.1. XM_005627070.2.
XP_013973519.1. XM_014118044.1.
UniGeneiCfa.43935.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000037824.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

PaxDbiQ5TJE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000001474; ENSCAFP00000037824; ENSCAFG00000000952.
GeneIDi481737.
KEGGicfa:481737.

Organism-specific databases

CTDi8705.

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOVERGENiHBG050651.
InParanoidiQ5TJE8.
KOiK00715.
OMAiPFCSWLQ.
OrthoDBiEOG76MK8S.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

NextBioi20856479.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the class II region of the canine MHC: comparison with the MHC of other mammalian species."
    Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A., Ollier W.E.R., Binns M.M.
    Genomics 85:48-59(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Doberman pinscher.

Entry informationi

Entry nameiB3GT4_CANLF
AccessioniPrimary (citable) accession number: Q5TJE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.