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Protein

Coiled-coil domain-containing protein 181

Gene

CCDC181

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 181
Gene namesi
Name:CCDC181
Synonyms:C1orf114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28051. CCDC181.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672498.

Polymorphism and mutation databases

BioMutaiCCDC181.
DMDMi74746645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Coiled-coil domain-containing protein 181PRO_0000279465Add
BLAST

Proteomic databases

PaxDbiQ5TID7.
PRIDEiQ5TID7.

PTM databases

iPTMnetiQ5TID7.
PhosphoSiteiQ5TID7.

Expressioni

Gene expression databases

BgeeiQ5TID7.
CleanExiHS_C1orf114.
ExpressionAtlasiQ5TID7. baseline and differential.
GenevisibleiQ5TID7. HS.

Organism-specific databases

HPAiHPA027189.
HPA027275.
HPA027281.
HPA027312.

Interactioni

Protein-protein interaction databases

BioGridi121780. 1 interaction.
IntActiQ5TID7. 1 interaction.
MINTiMINT-1193587.
STRINGi9606.ENSP00000356779.

Structurei

3D structure databases

ProteinModelPortaliQ5TID7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili335 – 37541Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi116 – 1227Poly-Glu

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHZS. Eukaryota.
ENOG410Z2JI. LUCA.
GeneTreeiENSGT00390000018244.
HOGENOMiHOG000111245.
HOVERGENiHBG080967.
InParanoidiQ5TID7.
OMAiKQEECLF.
OrthoDBiEOG7PP57Q.
PhylomeDBiQ5TID7.
TreeFamiTF331115.

Family and domain databases

InterProiIPR026687. UPF_C1orf114.
[Graphical view]
PANTHERiPTHR14320. PTHR14320. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TID7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNENKDTDSK KSEEYEDDFE KDLEWLINEN EKSDASIIEM ACEKEENINQ
60 70 80 90 100
DLKENETVME HTKRHSDPDK SLQDEVSPRR NDIISVPGIQ PLDPISDSDS
110 120 130 140 150
ENSFQESKLE SQKDLEEEED EEVRRYIMEK IVQANKLLQN QEPVNDKRER
160 170 180 190 200
KLKFKDQLVD LEVPPLEDTT TFKNYFENER NMFGKLSQLC ISNDFGQEDV
210 220 230 240 250
LLSLTNGSCE ENKDRTILVE RDGKFELLNL QDIASQGFLP PINNANSTEN
260 270 280 290 300
DPQQLLPRSS NSSVSGTKKE DSTAKIHAVT HSSTGEPLAY IAQPPLNRKT
310 320 330 340 350
CPSSAVNSDR SKGNGKSNHR TQSAHISPVT STYCLSPRQK ELQKQLEEKR
360 370 380 390 400
EKLKREEERR KIEEEKEKKR ENDIVFKAWL QKKREQVLEM RRIQRAKEIE
410 420 430 440 450
DMNSRQENRD PQQAFRLWLK KKHEEQMKER QTEELRKQEE CLFFLKGTEG
460 470 480 490 500
RERAFKQWLR RKRMEKMAEQ QAVRERTRQL RLEAKRSKQL QHHLYMSEAK

PFRFTDHYN
Length:509
Mass (Da):60,103
Last modified:December 21, 2004 - v1
Checksum:iF3FE11900539F24E
GO
Isoform 2 (identifier: Q5TID7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-509: QENRDPQQAF...KPFRFTDHYN → VSKTSLKNKFIQI

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):48,475
Checksum:iE022B5FB8C3097D7
GO
Isoform 3 (identifier: Q5TID7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-406: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):59,975
Checksum:i2523846316F81294
GO

Sequence cautioni

The sequence AAH26073.1 differs from that shown. Reason: Frameshift at position 370. Curated
The sequence CAI19784.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101R → Q in BAD97074 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721F → S.2 Publications
Corresponds to variant rs3820059 [ dbSNP | Ensembl ].
VAR_030907
Natural varianti238 – 2381F → I.1 Publication
Corresponds to variant rs35107735 [ dbSNP | Ensembl ].
VAR_056764
Natural varianti323 – 3231S → C.
Corresponds to variant rs35287513 [ dbSNP | Ensembl ].
VAR_056765

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei406 – 509104QENRD…TDHYN → VSKTSLKNKFIQI in isoform 2. 1 PublicationVSP_023448Add
BLAST
Alternative sequencei406 – 4061Missing in isoform 3. 1 PublicationVSP_023449

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049687 mRNA. Translation: CAB41258.1.
AK223354 mRNA. Translation: BAD97074.1.
AL021068 Genomic DNA. Translation: CAA15927.1.
AL021068 Genomic DNA. Translation: CAI19784.1. Sequence problems.
AL021068 Genomic DNA. Translation: CAI19785.1.
BC026073 mRNA. Translation: AAH26073.1. Frameshift.
CCDSiCCDS1279.1. [Q5TID7-3]
CCDS72979.1. [Q5TID7-1]
RefSeqiNP_001287897.1. NM_001300968.1. [Q5TID7-3]
NP_001287898.1. NM_001300969.1. [Q5TID7-1]
NP_067002.1. NM_021179.2. [Q5TID7-3]
XP_005245440.1. XM_005245383.1. [Q5TID7-1]
XP_011508129.1. XM_011509827.1. [Q5TID7-1]
UniGeneiHs.567557.
Hs.708673.

Genome annotation databases

EnsembliENST00000367805; ENSP00000356779; ENSG00000117477. [Q5TID7-3]
ENST00000367806; ENSP00000356780; ENSG00000117477. [Q5TID7-1]
ENST00000491570; ENSP00000479042; ENSG00000117477. [Q5TID7-2]
ENST00000545005; ENSP00000442297; ENSG00000117477. [Q5TID7-3]
GeneIDi57821.
KEGGihsa:57821.
UCSCiuc001gfz.2. human. [Q5TID7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049687 mRNA. Translation: CAB41258.1.
AK223354 mRNA. Translation: BAD97074.1.
AL021068 Genomic DNA. Translation: CAA15927.1.
AL021068 Genomic DNA. Translation: CAI19784.1. Sequence problems.
AL021068 Genomic DNA. Translation: CAI19785.1.
BC026073 mRNA. Translation: AAH26073.1. Frameshift.
CCDSiCCDS1279.1. [Q5TID7-3]
CCDS72979.1. [Q5TID7-1]
RefSeqiNP_001287897.1. NM_001300968.1. [Q5TID7-3]
NP_001287898.1. NM_001300969.1. [Q5TID7-1]
NP_067002.1. NM_021179.2. [Q5TID7-3]
XP_005245440.1. XM_005245383.1. [Q5TID7-1]
XP_011508129.1. XM_011509827.1. [Q5TID7-1]
UniGeneiHs.567557.
Hs.708673.

3D structure databases

ProteinModelPortaliQ5TID7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121780. 1 interaction.
IntActiQ5TID7. 1 interaction.
MINTiMINT-1193587.
STRINGi9606.ENSP00000356779.

PTM databases

iPTMnetiQ5TID7.
PhosphoSiteiQ5TID7.

Polymorphism and mutation databases

BioMutaiCCDC181.
DMDMi74746645.

Proteomic databases

PaxDbiQ5TID7.
PRIDEiQ5TID7.

Protocols and materials databases

DNASUi57821.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367805; ENSP00000356779; ENSG00000117477. [Q5TID7-3]
ENST00000367806; ENSP00000356780; ENSG00000117477. [Q5TID7-1]
ENST00000491570; ENSP00000479042; ENSG00000117477. [Q5TID7-2]
ENST00000545005; ENSP00000442297; ENSG00000117477. [Q5TID7-3]
GeneIDi57821.
KEGGihsa:57821.
UCSCiuc001gfz.2. human. [Q5TID7-1]

Organism-specific databases

CTDi57821.
GeneCardsiCCDC181.
HGNCiHGNC:28051. CCDC181.
HPAiHPA027189.
HPA027275.
HPA027281.
HPA027312.
neXtProtiNX_Q5TID7.
PharmGKBiPA142672498.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHZS. Eukaryota.
ENOG410Z2JI. LUCA.
GeneTreeiENSGT00390000018244.
HOGENOMiHOG000111245.
HOVERGENiHBG080967.
InParanoidiQ5TID7.
OMAiKQEECLF.
OrthoDBiEOG7PP57Q.
PhylomeDBiQ5TID7.
TreeFamiTF331115.

Miscellaneous databases

ChiTaRSiCCDC181. human.
GenomeRNAii57821.
NextBioi64786.
PROiQ5TID7.

Gene expression databases

BgeeiQ5TID7.
CleanExiHS_C1orf114.
ExpressionAtlasiQ5TID7. baseline and differential.
GenevisibleiQ5TID7. HS.

Family and domain databases

InterProiIPR026687. UPF_C1orf114.
[Graphical view]
PANTHERiPTHR14320. PTHR14320. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Rhodes S., Huckle E.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-172 AND ILE-238.
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-172.
    Tissue: Testis.

Entry informationi

Entry nameiCC181_HUMAN
AccessioniPrimary (citable) accession number: Q5TID7
Secondary accession number(s): O60780
, Q53FD5, Q5TID9, Q8TC48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.