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Protein
Submitted name:

E3 ubiquitin-protein ligase MYLIP

Gene

MYLIP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase MYLIPImported
Submitted name:
Myosin regulatory light chain interacting protein, isoform CRA_bImported
Gene namesi
Name:MYLIPImported
ORF Names:hCG_37431Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000007944.14
HGNCiHGNC:21155 MYLIP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007944

Expressioni

Gene expression databases

BgeeiENSG00000007944

Structurei

3D structure databases

SMRiQ5TIA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 98FERMInterPro annotationAdd BLAST98
Domaini206 – 241RING-typeInterPro annotationAdd BLAST36

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IG7I Eukaryota
ENOG410XRZN LUCA
GeneTreeiENSGT00890000139341
HOGENOMiHOG000007353
HOVERGENiHBG052549

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000299 FERM_domain
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
SMARTiView protein in SMART
SM01196 FERM_C, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TIA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYGIEWHS VRDSEGQKLL IGVGPEGISI CKDDFSPINR IAYPVVQMAT
60 70 80 90 100
QSGKNVYLTV TKESGNSIVL LFKMISTRAA SGLYRAITET HAFYRCDTVT
110 120 130 140 150
SAVMMQYSRD LKGHLASLFL NENINLGKKY VFDIKRTSKE VYDHARRALY
160 170 180 190 200
NAGVVDLVSR NNQSPSHSPL KSSESSMNCS SCEGLSCQQT RVLQEKLRKL
210 220 230 240 250
KEAMLCMVCC EEEINSTFCP CGHTVCCESC AAQLQSCPVC RSRVEHVQHV
260
YLPTHTSLLN LTVI
Length:264
Mass (Da):29,463
Last modified:February 20, 2007 - v2
Checksum:i50DDE3EC4DCC6A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021407 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55367.1
RefSeqiXP_005249090.1, XM_005249033.2
UniGeneiHs.484738

Genome annotation databases

EnsembliENST00000349606; ENSP00000008686; ENSG00000007944
GeneIDi29116
UCSCiuc003nbr.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5TIA5_HUMAN
AccessioniPrimary (citable) accession number: Q5TIA5
Secondary accession number(s): A6NHZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: February 20, 2007
Last modified: April 25, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health