ID MEI1_HUMAN Reviewed; 1274 AA. AC Q5TIA1; B7Z745; Q1XAP1; Q1XAP2; Q8IYJ5; Q8N5K5; Q8N9H3; Q8TC68; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 08-APR-2008, sequence version 2. DT 24-JAN-2024, entry version 111. DE RecName: Full=Meiosis inhibitor protein 1; DE AltName: Full=Meiosis defective protein 1; GN Name=MEI1 {ECO:0000312|HGNC:HGNC:28613}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAY27427.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, AND RP POSSIBLE INVOLVEMENT IN AZOOSPERMIA. RX PubMed=16683055; DOI=10.1007/s10038-006-0394-5; RA Sato H., Miyamoto T., Yogev L., Namiki M., Koh E., Hayashi H., Sasaki Y., RA Ishikawa M., Lamb D.J., Matsumoto N., Birk O.S., Niikawa N., Sengoku K.; RT "Polymorphic alleles of the human MEI1 gene are associated with human RT azoospermia by meiotic arrest."; RL J. Hum. Genet. 51:533-540(2006). RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC04361.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5). RC TISSUE=Cerebellum {ECO:0000312|EMBL:BAC04361.1}, and Synovial cell; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] {ECO:0000312|EMBL:Z83840} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [4] {ECO:0000305, ECO:0000312|EMBL:AAH25400.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 6 AND 7). RC TISSUE=Leukocyte {ECO:0000312|EMBL:AAH32248.1}, Ovary RC {ECO:0000312|EMBL:AAH35720.1}, and Testis RC {ECO:0000312|EMBL:AAH25400.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP VARIANT ARG-408, AND POSSIBLE INVOLVEMENT IN AZOOSPERMIA. RX PubMed=28718531; DOI=10.1111/andr.12378; RA Nakamura S., Miyado M., Saito K., Katsumi M., Nakamura A., Kobori Y., RA Tanaka Y., Ishikawa H., Yoshida A., Okada H., Hata K., Nakabayashi K., RA Okamura K., Ogata H., Matsubara Y., Ogata T., Nakai H., Fukami M.; RT "Next-generation sequencing for patients with non-obstructive azoospermia: RT implications for significant roles of monogenic/oligogenic mutations."; RL Andrology 5:824-831(2017). RN [6] RP VARIANT HYDM3 1151-TRP--ASN-1274 DEL, INVOLVEMENT IN HYDM3, AND TISSUE RP SPECIFICITY. RX PubMed=30388401; DOI=10.1016/j.ajhg.2018.10.007; RA Nguyen N.M.P., Ge Z.J., Reddy R., Fahiminiya S., Sauthier P., Bagga R., RA Sahin F.I., Mahadevan S., Osmond M., Breguet M., Rahimi K., Lapensee L., RA Hovanes K., Srinivasan R., Van den Veyver I.B., Sahoo T., Ao A., RA Majewski J., Taketo T., Slim R.; RT "Causative mutations and mechanism of androgenetic hydatidiform moles."; RL Am. J. Hum. Genet. 103:740-751(2018). RN [7] RP VARIANTS PHE-309 AND MET-363. RX PubMed=32741963; DOI=10.1038/s41436-020-0907-1; RA Krausz C., Riera-Escamilla A., Moreno-Mendoza D., Holleman K., Cioppi F., RA Algaba F., Pybus M., Friedrich C., Wyrwoll M.J., Casamonti E., RA Pietroforte S., Nagirnaja L., Lopes A.M., Kliesch S., Pilatz A., RA Carrell D.T., Conrad D.F., Ars E., Ruiz-Castane E., Aston K.I., RA Baarends W.M., Tuettelmann F.; RT "Genetic dissection of spermatogenic arrest through exome analysis: RT clinical implications for the management of azoospermic men."; RL Genet. Med. 22:1956-1966(2020). CC -!- FUNCTION: Required for normal meiotic chromosome synapsis. May be CC involved in the formation of meiotic double-strand breaks (DSBs) in CC spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q9D4I2}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=7; CC Name=1 {ECO:0000269|PubMed:10591208}; CC IsoId=Q5TIA1-1; Sequence=Displayed; CC Name=2 {ECO:0000269|PubMed:16683055}; Synonyms=Long CC {ECO:0000269|PubMed:16683055}; CC IsoId=Q5TIA1-2; Sequence=VSP_052885; CC Name=3 {ECO:0000269|PubMed:16683055}; Synonyms=Short CC {ECO:0000269|PubMed:16683055}; CC IsoId=Q5TIA1-3; Sequence=VSP_052885, VSP_052889; CC Name=4 {ECO:0000269|PubMed:15489334}; CC IsoId=Q5TIA1-4; Sequence=VSP_052887, VSP_052888; CC Name=5 {ECO:0000269|PubMed:14702039}; CC IsoId=Q5TIA1-5; Sequence=VSP_052884, VSP_052891; CC Name=6 {ECO:0000269|PubMed:15489334}; CC IsoId=Q5TIA1-6; Sequence=VSP_052886; CC Name=7 {ECO:0000269|PubMed:10591208, ECO:0000269|PubMed:15489334}; CC IsoId=Q5TIA1-7; Sequence=VSP_052883, VSP_052890; CC -!- TISSUE SPECIFICITY: Expressed predominantly in testis. Weakly expressed CC in spleen and thymus. Expressed in the ovaries, Fallopian tubes and CC uterus (PubMed:30388401). {ECO:0000269|PubMed:16683055, CC ECO:0000269|PubMed:30388401}. CC -!- DISEASE: Hydatidiform mole, recurrent, 3 (HYDM3) [MIM:618431]: A CC disorder characterized by excessive trophoblast development that CC produces a growing mass of tissue inside the uterus at the beginning of CC a pregnancy. It leads to abnormal pregnancies with no embryo, and CC cystic degeneration of the chorionic villi. CC {ECO:0000269|PubMed:30388401}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Note=Susceptibility to azoospermia may be associated with MEI1 CC variations. {ECO:0000269|PubMed:16683055, ECO:0000269|PubMed:28718531}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH25400.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=AAH35720.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY952376; AAY27427.1; -; mRNA. DR EMBL; AY952377; AAY27428.1; -; mRNA. DR EMBL; AK094461; BAC04361.1; -; mRNA. DR EMBL; AK301435; BAH13481.1; -; mRNA. DR EMBL; AL021453; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL023879; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Z83840; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC025400; AAH25400.1; ALT_INIT; mRNA. DR EMBL; BC032248; AAH32248.1; -; mRNA. DR EMBL; BC035720; AAH35720.1; ALT_INIT; mRNA. DR CCDS; CCDS46718.1; -. [Q5TIA1-1] DR RefSeq; NP_689726.3; NM_152513.3. [Q5TIA1-1] DR AlphaFoldDB; Q5TIA1; -. DR SMR; Q5TIA1; -. DR BioGRID; 127286; 8. DR IntAct; Q5TIA1; 1. DR STRING; 9606.ENSP00000384115; -. DR GlyGen; Q5TIA1; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q5TIA1; -. DR PhosphoSitePlus; Q5TIA1; -. DR BioMuta; MEI1; -. DR DMDM; 205815070; -. DR MassIVE; Q5TIA1; -. DR PaxDb; 9606-ENSP00000384115; -. DR PeptideAtlas; Q5TIA1; -. DR ProteomicsDB; 65181; -. [Q5TIA1-1] DR ProteomicsDB; 65182; -. [Q5TIA1-2] DR ProteomicsDB; 65183; -. [Q5TIA1-3] DR ProteomicsDB; 65185; -. [Q5TIA1-5] DR Antibodypedia; 27052; 88 antibodies from 16 providers. DR DNASU; 150365; -. DR Ensembl; ENST00000401548.8; ENSP00000384115.3; ENSG00000167077.13. [Q5TIA1-1] DR Ensembl; ENST00000403492.5; ENSP00000385298.1; ENSG00000167077.13. [Q5TIA1-7] DR GeneID; 150365; -. DR KEGG; hsa:150365; -. DR MANE-Select; ENST00000401548.8; ENSP00000384115.3; NM_152513.4; NP_689726.3. DR UCSC; uc003baz.2; human. [Q5TIA1-1] DR AGR; HGNC:28613; -. DR CTD; 150365; -. DR DisGeNET; 150365; -. DR GeneCards; MEI1; -. DR HGNC; HGNC:28613; MEI1. DR HPA; ENSG00000167077; Tissue enhanced (lymphoid tissue, testis). DR MalaCards; MEI1; -. DR MIM; 608797; gene. DR MIM; 618431; phenotype. DR neXtProt; NX_Q5TIA1; -. DR OpenTargets; ENSG00000167077; -. DR Orphanet; 254688; Complete hydatidiform mole. DR PharmGKB; PA162395678; -. DR VEuPathDB; HostDB:ENSG00000167077; -. DR eggNOG; ENOG502QV5Z; Eukaryota. DR GeneTree; ENSGT00390000002077; -. DR HOGENOM; CLU_006759_0_0_1; -. DR InParanoid; Q5TIA1; -. DR OMA; HTSLVTQ; -. DR OrthoDB; 2963827at2759; -. DR PhylomeDB; Q5TIA1; -. DR TreeFam; TF336500; -. DR PathwayCommons; Q5TIA1; -. DR SignaLink; Q5TIA1; -. DR BioGRID-ORCS; 150365; 11 hits in 1149 CRISPR screens. DR ChiTaRS; MEI1; human. DR GenomeRNAi; 150365; -. DR Pharos; Q5TIA1; Tbio. DR PRO; PR:Q5TIA1; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; Q5TIA1; Protein. DR Bgee; ENSG00000167077; Expressed in bone marrow cell and 116 other cell types or tissues. DR ExpressionAtlas; Q5TIA1; baseline and differential. DR GO; GO:0007127; P:meiosis I; IBA:GO_Central. DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR PANTHER; PTHR12044; BCL2 INTERACTING MEDIATOR OF CELL DEATH; 1. DR PANTHER; PTHR12044:SF10; MEIOSIS INHIBITOR PROTEIN 1; 1. DR SUPFAM; SSF48371; ARM repeat; 1. DR Genevisible; Q5TIA1; HS. PE 1: Evidence at protein level; KW Alternative splicing; Disease variant; Meiosis; Reference proteome. FT CHAIN 1..1274 FT /note="Meiosis inhibitor protein 1" FT /id="PRO_0000347264" FT VAR_SEQ 1..992 FT /note="Missing (in isoform 7)" FT /evidence="ECO:0000303|PubMed:10591208, FT ECO:0000303|PubMed:15489334" FT /id="VSP_052883" FT VAR_SEQ 1..757 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_052884" FT VAR_SEQ 1..632 FT /note="Missing (in isoform 2 and isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:16683055" FT /id="VSP_052885" FT VAR_SEQ 445..1274 FT /note="Missing (in isoform 6)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_052886" FT VAR_SEQ 561..569 FT /note="RHLEQTTHP -> VGSPEPRAT (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_052887" FT VAR_SEQ 570..1274 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_052888" FT VAR_SEQ 904..938 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:16683055" FT /id="VSP_052889" FT VAR_SEQ 1179..1222 FT /note="Missing (in isoform 7)" FT /evidence="ECO:0000303|PubMed:10591208, FT ECO:0000303|PubMed:15489334" FT /id="VSP_052890" FT VAR_SEQ 1193..1222 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_052891" FT VARIANT 309 FT /note="L -> F (found in a patient with non-obstructive FT azoospermia; uncertain significance)" FT /evidence="ECO:0000269|PubMed:32741963" FT /id="VAR_087425" FT VARIANT 363 FT /note="T -> M (found in a patient with non-obstructive FT azoospermia; uncertain significance)" FT /evidence="ECO:0000269|PubMed:32741963" FT /id="VAR_087426" FT VARIANT 408 FT /note="T -> R (found in patients with non-obstructive FT azoospermia; uncertain significance; dbSNP:rs533817526)" FT /evidence="ECO:0000269|PubMed:28718531" FT /id="VAR_081145" FT VARIANT 657 FT /note="E -> Q (in dbSNP:rs17002655)" FT /id="VAR_046037" FT VARIANT 853 FT /note="S -> T (in dbSNP:rs17002665)" FT /id="VAR_046038" FT VARIANT 1049 FT /note="K -> E (in dbSNP:rs12484839)" FT /id="VAR_051184" FT VARIANT 1151..1274 FT /note="Missing (in HYDM3; the variant leads to a normally FT spliced transcript and two abnormal isoforms)" FT /evidence="ECO:0000269|PubMed:30388401" FT /id="VAR_082605" FT CONFLICT 367 FT /note="I -> T (in Ref. 4; AAH35720)" FT /evidence="ECO:0000305" SQ SEQUENCE 1274 AA; 141161 MW; 3F339400DD50B11E CRC64; MAVRQAATAG TPGPRREEEA ALLFERAHYR HDPRWLLPVT PRLCLACALE LLPDPGVSLV RKKHMLSCFQ DALVRHTSLV TQLVSQDQRV CIHFISVLFG LLCSMEDGSV TDLCIEVLIQ ITTQLKLEQT IRCLLDECHK ELCNMPSMRG SLATLTLLGK LVDAIPALAD ELVMEHGNLM EHLLRGLVYP SEGIQASVCY LYGKLYSSPV AAEMLSGHFR EKLFPLFLSI LDGAQTKELQ INCLGLLRQL LKYDLFVSMI MNQDGLGESA KNIEGSSGNT SLPLVLKKLL LSRDETLQVA SAHCITAVLV HSPAKHASAF IHADIPEFLF EHLSSSSEVL VWSSCNCLTL LVEEPLFFSK CHTVYGIEAV VRSLQGSLKM NNIELHKQGL LLFAEILTRQ PEEIKLFTSS AMCRDAGRAL QEAVSSPVLE VAAEALKATS AFLRKDHQST PPVQYGELQA LLEAMLNRCA EFSQTLLSRR PLGHASSRDS EKAILQRGKF LLSTLEGFRS ACRLAIEFQS EPSAQENPFT APSAKKEDTL EAFSEFLLSA CDSLCIPMVM RHLEQTTHPA LMEVFLSILH NLFVIVPHMK EKFSKKLASS SFIRLTLELK ARFCSGLSHS ALNQVCSNFL YYMCLNLLSA PEKTGPPSKE ELSAVSELLQ HGLPQISSRS PESLAFLSDR QYMEGAARQR QYCILLLFYL AYIHEDRFVS EAELFEAVQS FLLSLQDQGE RPPLVVFKAS IYLLAICQDK DNTLRETMVS AIRKFLEGIP DLQLVYTHHP LLLRFFLLYP ELMSRYGHRV LELWFFWEES SYEELDDVTS AGQPALPASL VVLFQLLRSI PSILLILLDL IYSSPVDTAH KVLISLRTFL RRNEDIQVGG LIRGHFLLIL QRLLVEHGAS PSGASGNLPL LLSLLSLMQL RNVSEQELDS VAMKLLHQVS KLCGKCSPTD VDILQPSFNF LYWSLHQTTP SSQKRAAAVL LSSTGLMELL EKMLALTLAK ADSPRTALLC SAWLLTASFS AQQHKGSLQV HQTLSVEMDQ VLKALSFPKK KAALLSAAIL CFLRTALRQS FSSALVALVP SGAQPLPATK DTVLAPLRMS QVRSLVIGLQ NLLVQKDPLL SQACVGCLEA LLDYLDARSP DIALHVASQP WNRFLLFTLL DAGENSFLRP EILRLMTLFM RYRSSSVLSH EEVGDVLQGV ALADLSTLSN TTLQALHGFF QQLQSMGHLA DHSMAQTLQA SLEGLPPSTS SGQPPLQDML CLGGVAVSLS HIRN //