Q5TIA1 (MEI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Meiosis inhibitor protein 1

Alternative name(s):
Meiosis defective protein 1

Gene names

Name:

MEI1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1274 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes By similarity. UniProtKB Q9D4I2
Tissue specificity	Expressed predominantly in testis. Weakly expressed in spleen and thymus. Ref.1
Polymorphism	Genetic variation in MEI1 may predispose European American but not Israeli men to azoospermia by meiotic arrest. Ref.1
Sequence caution	The sequence AAH25400.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH35720.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Meiosis
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	male meiosis I Inferred from electronic annotation. Source: Compara spermatid development Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.3 (identifier: Q5TIA1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 Ref.1 (identifier: Q5TIA1-2)

Also known as: Long;

The sequence of this isoform differs from the canonical sequence as follows:
     1-632: Missing.

Isoform 3 Ref.1 (identifier: Q5TIA1-3)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-632: Missing.
     904-938: Missing.

Isoform 4 Ref.4 (identifier: Q5TIA1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     561-569: RHLEQTTHP → VGSPEPRAT
     570-1274: Missing.

Note: No experimental confirmation available.

Isoform 5 Ref.2 (identifier: Q5TIA1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-757: Missing.
     1193-1222: Missing.

Note: No experimental confirmation available.

Isoform 6 Ref.4 (identifier: Q5TIA1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     445-1274: Missing.

Note: No experimental confirmation available.

Isoform 7 Ref.3 Ref.4 (identifier: Q5TIA1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-992: Missing.
     1179-1222: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1274	1274	Meiosis inhibitor protein 1		PRO_0000347264
Natural variations
	Alternative sequence	1 – 992	992	Missing in isoform 7. Ref.3 Ref.4		VSP_052883
	Alternative sequence	1 – 757	757	Missing in isoform 5. Ref.2		VSP_052884
	Alternative sequence	1 – 632	632	Missing in isoform 2 and isoform 3. Ref.1		VSP_052885
	Alternative sequence	445 – 1274	830	Missing in isoform 6. Ref.4		VSP_052886
	Alternative sequence	561 – 569	9	RHLEQTTHP → VGSPEPRAT in isoform 4. Ref.4		VSP_052887
	Alternative sequence	570 – 1274	705	Missing in isoform 4. Ref.4		VSP_052888
	Alternative sequence	904 – 938	35	Missing in isoform 3. Ref.1		VSP_052889
	Alternative sequence	1179 – 1222	44	Missing in isoform 7. Ref.3 Ref.4		VSP_052890
	Alternative sequence	1193 – 1222	30	Missing in isoform 5. Ref.2		VSP_052891
	Natural variant	657	1	E → Q. Corresponds to variant rs17002655 [ dbSNP | Ensembl ].		VAR_046037
	Natural variant	853	1	S → T. Corresponds to variant rs17002665 [ dbSNP | Ensembl ].		VAR_046038
	Natural variant	1049	1	K → E. Corresponds to variant rs12484839 [ dbSNP | Ensembl ].		VAR_051184
Experimental info
	Sequence conflict	367	1	I → T in AAH35720. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: 3F339400DD50B11E	FASTA	1,274	141,161
	10 20 30 40 50 60 MAVRQAATAG TPGPRREEEA ALLFERAHYR HDPRWLLPVT PRLCLACALE LLPDPGVSLV 70 80 90 100 110 120 RKKHMLSCFQ DALVRHTSLV TQLVSQDQRV CIHFISVLFG LLCSMEDGSV TDLCIEVLIQ 130 140 150 160 170 180 ITTQLKLEQT IRCLLDECHK ELCNMPSMRG SLATLTLLGK LVDAIPALAD ELVMEHGNLM 190 200 210 220 230 240 EHLLRGLVYP SEGIQASVCY LYGKLYSSPV AAEMLSGHFR EKLFPLFLSI LDGAQTKELQ 250 260 270 280 290 300 INCLGLLRQL LKYDLFVSMI MNQDGLGESA KNIEGSSGNT SLPLVLKKLL LSRDETLQVA 310 320 330 340 350 360 SAHCITAVLV HSPAKHASAF IHADIPEFLF EHLSSSSEVL VWSSCNCLTL LVEEPLFFSK 370 380 390 400 410 420 CHTVYGIEAV VRSLQGSLKM NNIELHKQGL LLFAEILTRQ PEEIKLFTSS AMCRDAGRAL 430 440 450 460 470 480 QEAVSSPVLE VAAEALKATS AFLRKDHQST PPVQYGELQA LLEAMLNRCA EFSQTLLSRR 490 500 510 520 530 540 PLGHASSRDS EKAILQRGKF LLSTLEGFRS ACRLAIEFQS EPSAQENPFT APSAKKEDTL 550 560 570 580 590 600 EAFSEFLLSA CDSLCIPMVM RHLEQTTHPA LMEVFLSILH NLFVIVPHMK EKFSKKLASS 610 620 630 640 650 660 SFIRLTLELK ARFCSGLSHS ALNQVCSNFL YYMCLNLLSA PEKTGPPSKE ELSAVSELLQ 670 680 690 700 710 720 HGLPQISSRS PESLAFLSDR QYMEGAARQR QYCILLLFYL AYIHEDRFVS EAELFEAVQS 730 740 750 760 770 780 FLLSLQDQGE RPPLVVFKAS IYLLAICQDK DNTLRETMVS AIRKFLEGIP DLQLVYTHHP 790 800 810 820 830 840 LLLRFFLLYP ELMSRYGHRV LELWFFWEES SYEELDDVTS AGQPALPASL VVLFQLLRSI 850 860 870 880 890 900 PSILLILLDL IYSSPVDTAH KVLISLRTFL RRNEDIQVGG LIRGHFLLIL QRLLVEHGAS 910 920 930 940 950 960 PSGASGNLPL LLSLLSLMQL RNVSEQELDS VAMKLLHQVS KLCGKCSPTD VDILQPSFNF 970 980 990 1000 1010 1020 LYWSLHQTTP SSQKRAAAVL LSSTGLMELL EKMLALTLAK ADSPRTALLC SAWLLTASFS 1030 1040 1050 1060 1070 1080 AQQHKGSLQV HQTLSVEMDQ VLKALSFPKK KAALLSAAIL CFLRTALRQS FSSALVALVP 1090 1100 1110 1120 1130 1140 SGAQPLPATK DTVLAPLRMS QVRSLVIGLQ NLLVQKDPLL SQACVGCLEA LLDYLDARSP 1150 1160 1170 1180 1190 1200 DIALHVASQP WNRFLLFTLL DAGENSFLRP EILRLMTLFM RYRSSSVLSH EEVGDVLQGV 1210 1220 1230 1240 1250 1260 ALADLSTLSN TTLQALHGFF QQLQSMGHLA DHSMAQTLQA SLEGLPPSTS SGQPPLQDML 1270 CLGGVAVSLS HIRN
	Isoform 2 (Long) [UniParc]. Checksum: 7CC67F82BCCB6677	FASTA	642	71,012
	10 20 30 40 50 60 MCLNLLSAPE KTGPPSKEEL SAVSELLQHG LPQISSRSPE SLAFLSDRQY MEGAARQRQY 70 80 90 100 110 120 CILLLFYLAY IHEDRFVSEA ELFEAVQSFL LSLQDQGERP PLVVFKASIY LLAICQDKDN 130 140 150 160 170 180 TLRETMVSAI RKFLEGIPDL QLVYTHHPLL LRFFLLYPEL MSRYGHRVLE LWFFWEESSY 190 200 210 220 230 240 EELDDVTSAG QPALPASLVV LFQLLRSIPS ILLILLDLIY SSPVDTAHKV LISLRTFLRR 250 260 270 280 290 300 NEDIQVGGLI RGHFLLILQR LLVEHGASPS GASGNLPLLL SLLSLMQLRN VSEQELDSVA 310 320 330 340 350 360 MKLLHQVSKL CGKCSPTDVD ILQPSFNFLY WSLHQTTPSS QKRAAAVLLS STGLMELLEK 370 380 390 400 410 420 MLALTLAKAD SPRTALLCSA WLLTASFSAQ QHKGSLQVHQ TLSVEMDQVL KALSFPKKKA 430 440 450 460 470 480 ALLSAAILCF LRTALRQSFS SALVALVPSG AQPLPATKDT VLAPLRMSQV RSLVIGLQNL 490 500 510 520 530 540 LVQKDPLLSQ ACVGCLEALL DYLDARSPDI ALHVASQPWN RFLLFTLLDA GENSFLRPEI 550 560 570 580 590 600 LRLMTLFMRY RSSSVLSHEE VGDVLQGVAL ADLSTLSNTT LQALHGFFQQ LQSMGHLADH 610 620 630 640 SMAQTLQASL EGLPPSTSSG QPPLQDMLCL GGVAVSLSHI RN
	Isoform 3 (Short) [UniParc]. Checksum: 65F6318FF6D997EC	FASTA	607	67,167
	10 20 30 40 50 60 MCLNLLSAPE KTGPPSKEEL SAVSELLQHG LPQISSRSPE SLAFLSDRQY MEGAARQRQY 70 80 90 100 110 120 CILLLFYLAY IHEDRFVSEA ELFEAVQSFL LSLQDQGERP PLVVFKASIY LLAICQDKDN 130 140 150 160 170 180 TLRETMVSAI RKFLEGIPDL QLVYTHHPLL LRFFLLYPEL MSRYGHRVLE LWFFWEESSY 190 200 210 220 230 240 EELDDVTSAG QPALPASLVV LFQLLRSIPS ILLILLDLIY SSPVDTAHKV LISLRTFLRR 250 260 270 280 290 300 NEDIQVGGLI RGHFLLILQR LLVEHGASPS GVSKLCGKCS PTDVDILQPS FNFLYWSLHQ 310 320 330 340 350 360 TTPSSQKRAA AVLLSSTGLM ELLEKMLALT LAKADSPRTA LLCSAWLLTA SFSAQQHKGS 370 380 390 400 410 420 LQVHQTLSVE MDQVLKALSF PKKKAALLSA AILCFLRTAL RQSFSSALVA LVPSGAQPLP 430 440 450 460 470 480 ATKDTVLAPL RMSQVRSLVI GLQNLLVQKD PLLSQACVGC LEALLDYLDA RSPDIALHVA 490 500 510 520 530 540 SQPWNRFLLF TLLDAGENSF LRPEILRLMT LFMRYRSSSV LSHEEVGDVL QGVALADLST 550 560 570 580 590 600 LSNTTLQALH GFFQQLQSMG HLADHSMAQT LQASLEGLPP STSSGQPPLQ DMLCLGGVAV SLSHIRN
	Isoform 4 [UniParc]. Checksum: 33FEE854AC0C1B16	FASTA	569	62,758
	10 20 30 40 50 60 MAVRQAATAG TPGPRREEEA ALLFERAHYR HDPRWLLPVT PRLCLACALE LLPDPGVSLV 70 80 90 100 110 120 RKKHMLSCFQ DALVRHTSLV TQLVSQDQRV CIHFISVLFG LLCSMEDGSV TDLCIEVLIQ 130 140 150 160 170 180 ITTQLKLEQT IRCLLDECHK ELCNMPSMRG SLATLTLLGK LVDAIPALAD ELVMEHGNLM 190 200 210 220 230 240 EHLLRGLVYP SEGIQASVCY LYGKLYSSPV AAEMLSGHFR EKLFPLFLSI LDGAQTKELQ 250 260 270 280 290 300 INCLGLLRQL LKYDLFVSMI MNQDGLGESA KNIEGSSGNT SLPLVLKKLL LSRDETLQVA 310 320 330 340 350 360 SAHCITAVLV HSPAKHASAF IHADIPEFLF EHLSSSSEVL VWSSCNCLTL LVEEPLFFSK 370 380 390 400 410 420 CHTVYGIEAV VRSLQGSLKM NNIELHKQGL LLFAEILTRQ PEEIKLFTSS AMCRDAGRAL 430 440 450 460 470 480 QEAVSSPVLE VAAEALKATS AFLRKDHQST PPVQYGELQA LLEAMLNRCA EFSQTLLSRR 490 500 510 520 530 540 PLGHASSRDS EKAILQRGKF LLSTLEGFRS ACRLAIEFQS EPSAQENPFT APSAKKEDTL 550 560 EAFSEFLLSA CDSLCIPMVM VGSPEPRAT
	Isoform 5 [UniParc]. Checksum: E2FBC0BCCF47D825	FASTA	487	53,736
	10 20 30 40 50 60 MVSAIRKFLE GIPDLQLVYT HHPLLLRFFL LYPELMSRYG HRVLELWFFW EESSYEELDD 70 80 90 100 110 120 VTSAGQPALP ASLVVLFQLL RSIPSILLIL LDLIYSSPVD TAHKVLISLR TFLRRNEDIQ 130 140 150 160 170 180 VGGLIRGHFL LILQRLLVEH GASPSGASGN LPLLLSLLSL MQLRNVSEQE LDSVAMKLLH 190 200 210 220 230 240 QVSKLCGKCS PTDVDILQPS FNFLYWSLHQ TTPSSQKRAA AVLLSSTGLM ELLEKMLALT 250 260 270 280 290 300 LAKADSPRTA LLCSAWLLTA SFSAQQHKGS LQVHQTLSVE MDQVLKALSF PKKKAALLSA 310 320 330 340 350 360 AILCFLRTAL RQSFSSALVA LVPSGAQPLP ATKDTVLAPL RMSQVRSLVI GLQNLLVQKD 370 380 390 400 410 420 PLLSQACVGC LEALLDYLDA RSPDIALHVA SQPWNRFLLF TLLDAGENSF LRPEILRLMT 430 440 450 460 470 480 LFMRYRSSSV LSHEELQSMG HLADHSMAQT LQASLEGLPP STSSGQPPLQ DMLCLGGVAV SLSHIRN
	Isoform 6 [UniParc]. Checksum: 9FAFEDC4D6CC5CF1	FASTA	444	49,015
	10 20 30 40 50 60 MAVRQAATAG TPGPRREEEA ALLFERAHYR HDPRWLLPVT PRLCLACALE LLPDPGVSLV 70 80 90 100 110 120 RKKHMLSCFQ DALVRHTSLV TQLVSQDQRV CIHFISVLFG LLCSMEDGSV TDLCIEVLIQ 130 140 150 160 170 180 ITTQLKLEQT IRCLLDECHK ELCNMPSMRG SLATLTLLGK LVDAIPALAD ELVMEHGNLM 190 200 210 220 230 240 EHLLRGLVYP SEGIQASVCY LYGKLYSSPV AAEMLSGHFR EKLFPLFLSI LDGAQTKELQ 250 260 270 280 290 300 INCLGLLRQL LKYDLFVSMI MNQDGLGESA KNIEGSSGNT SLPLVLKKLL LSRDETLQVA 310 320 330 340 350 360 SAHCITAVLV HSPAKHASAF IHADIPEFLF EHLSSSSEVL VWSSCNCLTL LVEEPLFFSK 370 380 390 400 410 420 CHTVYGIEAV VRSLQGSLKM NNIELHKQGL LLFAEILTRQ PEEIKLFTSS AMCRDAGRAL 430 440 QEAVSSPVLE VAAEALKATS AFLR
	Isoform 7 [UniParc]. Checksum: 4A13904D7038F278	FASTA	238	25,555
	10 20 30 40 50 60 MLALTLAKAD SPRTALLCSA WLLTASFSAQ QHKGSLQVHQ TLSVEMDQVL KALSFPKKKA 70 80 90 100 110 120 ALLSAAILCF LRTALRQSFS SALVALVPSG AQPLPATKDT VLAPLRMSQV RSLVIGLQNL 130 140 150 160 170 180 LVQKDPLLSQ ACVGCLEALL DYLDARSPDI ALHVASQPWN RFLLFTLLDA GENSFLRPEI 190 200 210 220 230 LRLMTLLQSM GHLADHSMAQ TLQASLEGLP PSTSSGQPPL QDMLCLGGVA VSLSHIRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest." Sato H., Miyamoto T., Yogev L., Namiki M., Koh E., Hayashi H., Sasaki Y., Ishikawa M., Lamb D.J., Matsumoto N., Birk O.S., Niikawa N., Sengoku K. J. Hum. Genet. 51:533-540(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, POLYMORPHISM.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5). Tissue: Cerebellum and Synovial cell.
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 6 AND 7). Tissue: Leukocyte, Ovary and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY952376 mRNA. Translation: AAY27427.1. AY952377 mRNA. Translation: AAY27428.1. AK094461 mRNA. Translation: BAC04361.1. AK301435 mRNA. Translation: BAH13481.1. AL021453, AL023879, Z83840 Genomic DNA. Translation: CAI22918.2. AL021453 Genomic DNA. Translation: CAQ09777.1. AL023879, AL021453, Z83840 Genomic DNA. Translation: CAQ10977.1. Z83840, AL021453, AL023879 Genomic DNA. Translation: CAI17919.2. BC025400 mRNA. Translation: AAH25400.1. Different initiation. BC032248 mRNA. Translation: AAH32248.1. BC035720 mRNA. Translation: AAH35720.1. Different initiation.
IPI	IPI00290916. IPI00795870. IPI00892706. IPI00902519. IPI00902603. IPI00902940. IPI00903317.
RefSeq	NP_689726.3. NM_152513.3.
UniGene	Hs.116419.
3D structure databases
ProteinModelPortal	Q5TIA1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000384115.
PTM databases
PhosphoSite	Q5TIA1.
Polymorphism databases
DMDM	205815070.
Proteomic databases
PaxDb	Q5TIA1.
PRIDE	Q5TIA1.
Protocols and materials databases
DNASU	150365.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300398; ENSP00000300398; ENSG00000167077. ENST00000400107; ENSP00000382978; ENSG00000167077. ENST00000401548; ENSP00000384115; ENSG00000167077. ENST00000403492; ENSP00000385298; ENSG00000167077.
GeneID	150365.
KEGG	hsa:150365.
UCSC	uc003bay.3. human. uc003baz.1. human. uc003bbb.1. human. uc003bbd.1. human. uc003bbg.2. human. uc010gym.1. human.
Organism-specific databases
CTD	150365.
GeneCards	GC22P042095.
H-InvDB	HIX0016529.
HGNC	HGNC:28613. MEI1.
HPA	HPA049240.
MIM	608797. gene.
neXtProt	NX_Q5TIA1.
PharmGKB	PA162395678.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73841.
HOVERGEN	HBG108129.
OMA	QHLLVEH.
OrthoDB	EOG4P2Q1G.
Gene expression databases
ArrayExpress	Q5TIA1.
Bgee	Q5TIA1.
CleanEx	HS_MEI1.
Genevestigator	Q5TIA1.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	150365.
NextBio	86420.
SOURCE	Search...

Entry information

Entry name

MEI1_HUMAN

Accession

Primary (citable) accession number: Q5TIA1
Secondary accession number(s): B7Z745 , Q1XAP1, Q1XAP2, Q8IYJ5, Q8N5K5, Q8N9H3, Q8TC68

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.