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Protein

Mitochondrial pyruvate carrier

Gene

BRP44L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.UniRule annotation

GO - Biological processi

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrierUniRule annotation
Gene namesi
Name:BRP44LImported
Synonyms:MPC1Imported
ORF Names:hCG_15016Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21606. MPC1.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000060762.

Expressioni

Gene expression databases

BgeeiENSG00000060762.

Interactioni

Protein-protein interaction databases

MINTiMINT-1417282.
STRINGi9606.ENSP00000354223.

Family & Domainsi

Sequence similaritiesi

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiKOG1590. Eukaryota.
ENOG4111TU9. LUCA.
GeneTreeiENSGT00510000046988.
HOGENOMiHOG000188911.

Family and domain databases

InterProiView protein in InterPro
IPR005336. MPC.
PfamiView protein in Pfam
PF03650. MPC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TI65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSPEIISG RMTFALCCYS LTFMRFAYKV QPRNWLLFAC HATNEVAQLI
60
QGGRLIKHEM TKTASA
Length:66
Mass (Da):7,540
Last modified:December 21, 2004 - v1
Checksum:iB79104C4D22099A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022069 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47527.1.
CH471051 Genomic DNA. Translation: EAW47528.1.
CH471051 Genomic DNA. Translation: EAW47529.1.
CH471051 Genomic DNA. Translation: EAW47530.1.
CH471051 Genomic DNA. Translation: EAW47531.1.
RefSeqiNP_001257808.1. NM_001270879.1.
XP_011534196.1. XM_011535894.1.
XP_011534197.1. XM_011535895.1.
UniGeneiHs.172755.

Genome annotation databases

EnsembliENST00000341756; ENSP00000340784; ENSG00000060762.
ENST00000621685; ENSP00000477853; ENSG00000060762.
GeneIDi51660.
UCSCiuc031sra.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022069 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47527.1.
CH471051 Genomic DNA. Translation: EAW47528.1.
CH471051 Genomic DNA. Translation: EAW47529.1.
CH471051 Genomic DNA. Translation: EAW47530.1.
CH471051 Genomic DNA. Translation: EAW47531.1.
RefSeqiNP_001257808.1. NM_001270879.1.
XP_011534196.1. XM_011535894.1.
XP_011534197.1. XM_011535895.1.
UniGeneiHs.172755.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1417282.
STRINGi9606.ENSP00000354223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341756; ENSP00000340784; ENSG00000060762.
ENST00000621685; ENSP00000477853; ENSG00000060762.
GeneIDi51660.
UCSCiuc031sra.2. human.

Organism-specific databases

CTDi51660.
HGNCiHGNC:21606. MPC1.
OpenTargetsiENSG00000060762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1590. Eukaryota.
ENOG4111TU9. LUCA.
GeneTreeiENSGT00510000046988.
HOGENOMiHOG000188911.

Miscellaneous databases

GenomeRNAii51660.

Gene expression databases

BgeeiENSG00000060762.

Family and domain databases

InterProiView protein in InterPro
IPR005336. MPC.
PfamiView protein in Pfam
PF03650. MPC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TI65_HUMAN
AccessioniPrimary (citable) accession number: Q5TI65
Secondary accession number(s): H7BXW7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 10, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.