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Protein

Mitochondrial pyruvate carrier

Gene

BRP44L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrierUniRule annotation
Gene namesi
Name:BRP44LImported
Synonyms:MPC1Imported
ORF Names:hCG_15016Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21606. MPC1.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000060762.

PTM / Processingi

Proteomic databases

EPDiQ5TI65.
MaxQBiQ5TI65.
PeptideAtlasiQ5TI65.
PRIDEiQ5TI65.

Expressioni

Gene expression databases

BgeeiENSG00000060762.
ExpressionAtlasiQ5TI65. baseline and differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-1417282.
STRINGi9606.ENSP00000354223.

Structurei

3D structure databases

ProteinModelPortaliQ5TI65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiKOG1590. Eukaryota.
ENOG4111TU9. LUCA.
GeneTreeiENSGT00510000046988.
HOGENOMiHOG000188911.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TI65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSPEIISG RMTFALCCYS LTFMRFAYKV QPRNWLLFAC HATNEVAQLI
60
QGGRLIKHEM TKTASA
Length:66
Mass (Da):7,540
Last modified:December 21, 2004 - v1
Checksum:iB79104C4D22099A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022069 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47527.1.
CH471051 Genomic DNA. Translation: EAW47528.1.
CH471051 Genomic DNA. Translation: EAW47529.1.
CH471051 Genomic DNA. Translation: EAW47530.1.
CH471051 Genomic DNA. Translation: EAW47531.1.
RefSeqiNP_001257808.1. NM_001270879.1.
XP_011534196.1. XM_011535894.1.
XP_011534197.1. XM_011535895.1.
UniGeneiHs.172755.

Genome annotation databases

EnsembliENST00000341756; ENSP00000340784; ENSG00000060762.
ENST00000621685; ENSP00000477853; ENSG00000060762.
GeneIDi51660.
UCSCiuc031sra.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022069 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47527.1.
CH471051 Genomic DNA. Translation: EAW47528.1.
CH471051 Genomic DNA. Translation: EAW47529.1.
CH471051 Genomic DNA. Translation: EAW47530.1.
CH471051 Genomic DNA. Translation: EAW47531.1.
RefSeqiNP_001257808.1. NM_001270879.1.
XP_011534196.1. XM_011535894.1.
XP_011534197.1. XM_011535895.1.
UniGeneiHs.172755.

3D structure databases

ProteinModelPortaliQ5TI65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1417282.
STRINGi9606.ENSP00000354223.

Proteomic databases

EPDiQ5TI65.
MaxQBiQ5TI65.
PeptideAtlasiQ5TI65.
PRIDEiQ5TI65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341756; ENSP00000340784; ENSG00000060762.
ENST00000621685; ENSP00000477853; ENSG00000060762.
GeneIDi51660.
UCSCiuc031sra.2. human.

Organism-specific databases

CTDi51660.
HGNCiHGNC:21606. MPC1.
OpenTargetsiENSG00000060762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1590. Eukaryota.
ENOG4111TU9. LUCA.
GeneTreeiENSGT00510000046988.
HOGENOMiHOG000188911.

Miscellaneous databases

GenomeRNAii51660.

Gene expression databases

BgeeiENSG00000060762.
ExpressionAtlasiQ5TI65. baseline and differential.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TI65_HUMAN
AccessioniPrimary (citable) accession number: Q5TI65
Secondary accession number(s): H7BXW7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.