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Protein

Neuroblastoma breakpoint family member 14

Gene

NBPF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 14
Gene namesi
Name:NBPF14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:25232. NBPF14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi25832.
PharmGKBiPA142671273.

Polymorphism and mutation databases

DMDMi152123242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880481 – 921Neuroblastoma breakpoint family member 14Add BLAST921

Proteomic databases

MaxQBiQ5TI25.
PaxDbiQ5TI25.
PeptideAtlasiQ5TI25.
PRIDEiQ5TI25.

PTM databases

iPTMnetiQ5TI25.
PhosphoSitePlusiQ5TI25.

Expressioni

Tissue specificityi

Expressed in spleen and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000122497.
CleanExiHS_NBPF14.

Organism-specific databases

HPAiHPA042595.
HPA043105.
HPA043692.
HPA044023.
HPA046971.

Interactioni

Protein-protein interaction databases

IntActiQ5TI25. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ5TI25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 188NBPF 1PROSITE-ProRule annotationAdd BLAST93
Domaini189 – 260NBPF 2PROSITE-ProRule annotationAdd BLAST72
Domaini261 – 352NBPF 3PROSITE-ProRule annotationAdd BLAST92
Domaini355 – 410NBPF 4PROSITE-ProRule annotationAdd BLAST56
Domaini411 – 503NBPF 5PROSITE-ProRule annotationAdd BLAST93
Domaini504 – 596NBPF 6PROSITE-ProRule annotationAdd BLAST93
Domaini599 – 671NBPF 7PROSITE-ProRule annotationAdd BLAST73
Domaini674 – 729NBPF 8PROSITE-ProRule annotationAdd BLAST56
Domaini730 – 822NBPF 9PROSITE-ProRule annotationAdd BLAST93
Domaini823 – 921NBPF 10PROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 61Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 199Poly-Glu5
Compositional biasi210 – 215Poly-Glu6
Compositional biasi417 – 420Poly-Glu4
Compositional biasi736 – 739Poly-Glu4

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 10 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410KG3F. Eukaryota.
ENOG4110SQ7. LUCA.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ5TI25.
PhylomeDBiQ5TI25.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 10 hits.
[Graphical view]
SMARTiSM01148. DUF1220. 10 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TI25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNERQFKE EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA
60 70 80 90 100
SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND
110 120 130 140 150
DDEDVQVEVA EKVQKSSAPR EMQKAEEKEV PEDSLEECAI TCSNSHGPYD
160 170 180 190 200
SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK
210 220 230 240 250
GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPEMLASYKS YSSTFHSLEE
260 270 280 290 300
QQVCMAVDIG RHRWDQVKKE DHEATGPRLS RELLDEKGPE VLQDSLDRCY
310 320 330 340 350
STPSGCLELT DSCQPYRSAF YVLEQQRVGL AVNMDEIEKY QEVEEDQDPS
360 370 380 390 400
CPRLSRELLD EKEPEVLQDS LGRCYSTPSG YLELPDLGQP YSSAVYSLEE
410 420 430 440 450
QYLGLALDVD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDRCY
460 470 480 490 500
STPSSCLEQP DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR
510 520 530 540 550
SKKERRRGRK EGEEDQNPPC PRLSRELLDE KGPEVLQDSL DRCYSTPSGC
560 570 580 590 600
LELTDSCQPY RSAFYILEQQ RVGLAVDMDE IEKYQEVEED QDPSCPRLSG
610 620 630 640 650
ELLDEKEPEV LQESLDRCYS TPSGCLELTD SCQPYRSAFY ILEQQRVGLA
660 670 680 690 700
VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL GRCYSTPSGY
710 720 730 740 750
LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR
760 770 780 790 800
ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS
810 820 830 840 850
LDVGEIEKKG KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLNSMLMEVE
860 870 880 890 900
EPEVLQDSLD ICYSTPSMYF ELPDSFQHYR SVFYSFEEEH ISFALYVDNR
910 920
FFTLTVTSLH LVFQMGVIFP Q
Length:921
Mass (Da):105,853
Last modified:May 29, 2007 - v2
Checksum:i3FFFFEBD47514717
GO

Sequence cautioni

The sequence CAI20179 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI20180 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20181 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20182 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20183 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20184 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20185 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20186 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti333N → D in AAO15399 (PubMed:16079250).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032381243S → G.Corresponds to variant rs3871941dbSNPEnsembl.1
Natural variantiVAR_032382571R → C.Corresponds to variant rs17433673dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117237 mRNA. Translation: CAB55305.1.
AL022240 Genomic DNA. Translation: CAI20179.1. Different initiation.
AL022240 Genomic DNA. Translation: CAI20180.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20181.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20182.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20183.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20184.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20185.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20186.1. Sequence problems.
AF379631 mRNA. Translation: AAO15399.1.
UniGeneiHs.534675.
Hs.714127.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117237 mRNA. Translation: CAB55305.1.
AL022240 Genomic DNA. Translation: CAI20179.1. Different initiation.
AL022240 Genomic DNA. Translation: CAI20180.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20181.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20182.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20183.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20184.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20185.1. Sequence problems.
AL022240 Genomic DNA. Translation: CAI20186.1. Sequence problems.
AF379631 mRNA. Translation: AAO15399.1.
UniGeneiHs.534675.
Hs.714127.

3D structure databases

ProteinModelPortaliQ5TI25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5TI25. 1 interactor.

PTM databases

iPTMnetiQ5TI25.
PhosphoSitePlusiQ5TI25.

Polymorphism and mutation databases

DMDMi152123242.

Proteomic databases

MaxQBiQ5TI25.
PaxDbiQ5TI25.
PeptideAtlasiQ5TI25.
PRIDEiQ5TI25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi25832.
GeneCardsiNBPF14.
H-InvDBHIX0023724.
HGNCiHGNC:25232. NBPF14.
HPAiHPA042595.
HPA043105.
HPA043692.
HPA044023.
HPA046971.
MIMi614003. gene.
neXtProtiNX_Q5TI25.
PharmGKBiPA142671273.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KG3F. Eukaryota.
ENOG4110SQ7. LUCA.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ5TI25.
PhylomeDBiQ5TI25.

Miscellaneous databases

ChiTaRSiNBPF14. human.
PROiQ5TI25.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122497.
CleanExiHS_NBPF14.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 10 hits.
[Graphical view]
SMARTiSM01148. DUF1220. 10 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNBPFE_HUMAN
AccessioniPrimary (citable) accession number: Q5TI25
Secondary accession number(s): Q5TI23, Q8IX76, Q9UJI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.