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Protein

EF-hand calcium-binding domain-containing protein 6

Gene

EFCAB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi754 – 765PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 6
Alternative name(s):
CAP-binding protein complex-interacting protein 1
DJ-1-binding protein
Short name:
DJBP
Gene namesi
Name:EFCAB6
Synonyms:DJBP, KIAA1672
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:24204. EFCAB6.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186976.
PharmGKBiPA162384324.

Polymorphism and mutation databases

BioMutaiEFCAB6.
DMDMi74756634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002460241 – 1501EF-hand calcium-binding domain-containing protein 6Add BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei884PhosphothreonineBy similarity1
Modified residuei1290PhosphoserineBy similarity1
Modified residuei1294PhosphothreonineBy similarity1
Modified residuei1304PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5THR3.
PaxDbiQ5THR3.
PeptideAtlasiQ5THR3.
PRIDEiQ5THR3.

PTM databases

iPTMnetiQ5THR3.
PhosphoSitePlusiQ5THR3.

Expressioni

Tissue specificityi

Specifically expressed in the testis.1 Publication

Gene expression databases

BgeeiENSG00000186976.
CleanExiHS_EFCAB6.
ExpressionAtlasiQ5THR3. baseline and differential.
GenevisibleiQ5THR3. HS.

Organism-specific databases

HPAiHPA003098.
HPA018946.

Interactioni

Subunit structurei

Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.

Protein-protein interaction databases

BioGridi122306. 4 interactors.
IntActiQ5THR3. 1 interactor.
STRINGi9606.ENSP00000262726.

Structurei

Secondary structure

11501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1164 – 1176Combined sources13
Helixi1178 – 1188Combined sources11
Beta strandi1194 – 1196Combined sources3
Helixi1198 – 1208Combined sources11
Helixi1214 – 1221Combined sources8
Helixi1234 – 1241Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WLZX-ray1.60A/B/C/D1160-1260[»]
5D67X-ray2.00A/B/C/D1160-1260[»]
ProteinModelPortaliQ5THR3.
SMRiQ5THR3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5THR3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 105EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini172 – 207EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini297 – 332EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini403 – 438EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini439 – 474EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini504 – 539EF-hand 6PROSITE-ProRule annotationAdd BLAST36
Domaini634 – 669EF-hand 7PROSITE-ProRule annotationAdd BLAST36
Domaini741 – 776EF-hand 8PROSITE-ProRule annotationAdd BLAST36
Domaini847 – 882EF-hand 9PROSITE-ProRule annotationAdd BLAST36
Domaini883 – 918EF-hand 10PROSITE-ProRule annotationAdd BLAST36
Domaini964 – 999EF-hand 11PROSITE-ProRule annotationAdd BLAST36
Domaini1069 – 1104EF-hand 12PROSITE-ProRule annotationAdd BLAST36
Domaini1176 – 1211EF-hand 13PROSITE-ProRule annotationAdd BLAST36
Domaini1212 – 1247EF-hand 14PROSITE-ProRule annotationAdd BLAST36
Domaini1359 – 1394EF-hand 15PROSITE-ProRule annotationAdd BLAST36
Domaini1434 – 1469EF-hand 16PROSITE-ProRule annotationAdd BLAST36
Domaini1470 – 1501EF-hand 17PROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1303 – 1501Interaction with PARK71 PublicationAdd BLAST199
Regioni1407 – 1501Interaction with AR1 PublicationAdd BLAST95

Sequence similaritiesi

Contains 17 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013629.
HOVERGENiHBG095997.
InParanoidiQ5THR3.
OMAiVLKDFCY.
OrthoDBiEOG091G0TP8.
PhylomeDBiQ5THR3.
TreeFamiTF329179.

Family and domain databases

Gene3Di1.10.238.10. 12 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR015070. EF_hand_DJBP.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF08976. EF-hand_11. 2 hits.
PF13833. EF-hand_8. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 12 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 13 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 17 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5THR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCKMAIIPDW LRSHPHTRKF THSRPHSSPC RVYSRNGSPN KFRSSSTTAV
60 70 80 90 100
ANPTLSSLDV KRILFQKITD RGDELQKAFQ LLDTGQNLTV SKSELRRIIT
110 120 130 140 150
DFLMPLTREQ FQDVLAQIPL STSGTVPYLA FLSRFGGIDL YINGIKRGGG
160 170 180 190 200
NEMNCCRTLR ELEIQVGEKV FKNIKTVMKA FELIDVNKTG LVRPQELRRV
210 220 230 240 250
LETFCMKLRD EEYEKFSKHY NIHKDTAVDY NVFLKNLSIN NDLNLRYCMG
260 270 280 290 300
NQEVSLENQQ AKNSKKERLL GSASSEDIWR NYSLDEIERN FCLQLSKSYE
310 320 330 340 350
KVEKALSAGD PCKGGYVSFN YLKIVLDTFV YQIPRRIFIQ LMKRFGLKAT
360 370 380 390 400
TKINWKQFLT SFHEPQGLQV SSKGPLTKRN SINSRNESHK ENIITKLFRH
410 420 430 440 450
TEDHSASLKK ALLIINTKPD GPITREEFRY ILNCMAVKLS DSEFKELMQM
460 470 480 490 500
LDPGDTGVVN TSMFIDLIEE NCRMRKTSPC TDAKTPFLLA WDSVEEIVHD
510 520 530 540 550
TITRNLQAFY NMLRSYDLGD TGRIGRNNFK KIMHVFCPFL TNAHFIKLCS
560 570 580 590 600
KIQDIGSGRI LYKKLLACIG IDGPPTVSPV LVPKDQLLSE HLQKDEQQQP
610 620 630 640 650
DLSERTKLTE DKTTLTKKMT TEEVIEKFKK CIQQQDPAFK KRFLDFSKEP
660 670 680 690 700
NGKINVHDFK KVLEDTGMPM DDDQYALLTT KIGFEKEGMS YLDFAAGFED
710 720 730 740 750
PPMRGPETTP PQPPTPSKSY VNSHFITAEE CLKLFPRRLK ESFRDPYSAF
760 770 780 790 800
FKTDADRDGI INMHDLHRLL LHLLLNLKDD EFERFLGLLG LRLSVTLNFR
810 820 830 840 850
EFQNLCEKRP WRTDEAPQRL IRPKQKVADS ELACEQAHQY LVTKAKNRWS
860 870 880 890 900
DLSKNFLETD NEGNGILRRR DIKNALYGFD IPLTPREFEK LWARYDTEGK
910 920 930 940 950
GHITYQEFLQ KLGINYSPAV HRPCAEDYFN FMGHFTKPQQ LQEEMKELQQ
960 970 980 990 1000
STEKAVAARD KLMDRHQDIS KAFTKTDQSK TNYISICKMQ EVLEECGCSL
1010 1020 1030 1040 1050
TEGELTHLLN SWGVSRHDNA INYLDFLRAV ENSKSTGAQP KEKEESMPIN
1060 1070 1080 1090 1100
FATLNPQEAV RKIQEVVESS QLALSTAFSA LDKEDTGFVK ATEFGQVLKD
1110 1120 1130 1140 1150
FCYKLTDNQY HYFLRKLRIH LTPYINWKYF LQNFSCFLEE TADEWAEKMP
1160 1170 1180 1190 1200
KGPPPTSPKA TADRDILARL HKAVTSHYHA ITQEFENFDT MKTNTISREE
1210 1220 1230 1240 1250
FRAICNRRVQ ILTDEQFDRL WNEMPVNAKG RLKYPDFLSR FSSETAATPM
1260 1270 1280 1290 1300
ATGDSAVAQR GSSVPDVSEG TRSALSLPTQ ELRPGSKSQS HPCTPASTTV
1310 1320 1330 1340 1350
IPGTPPLQNC DPIESRLRKR IQGCWRQLLK ECKEKDVARQ GDINASDFLA
1360 1370 1380 1390 1400
LVEKFNLDIS KEECQQLIIK YDLKSNGKFA YCDFIQSCVL LLKAKESSLM
1410 1420 1430 1440 1450
HRMKIQNAHK MKEAGAETPS FYSALLRIQP KIVHCWRPMR RTFKSYDEAG
1460 1470 1480 1490 1500
TGLLSVADFR TVLRQYSINL SEEEFFHILE YYDKTLSSKI SYNDFLRAFL

Q
Length:1,501
Mass (Da):172,930
Last modified:December 21, 2004 - v1
Checksum:i1D380F63D7FA8FF9
GO
Isoform 2 (identifier: Q5THR3-2) [UniParc]FASTAAdd to basket
Also known as: Isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Show »
Length:1,349
Mass (Da):155,839
Checksum:iF87F0B8368C7E476
GO
Isoform 3 (identifier: Q5THR3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-931: Missing.

Show »
Length:570
Mass (Da):65,308
Checksum:iF3FB697CB1D3161E
GO
Isoform 4 (identifier: Q5THR3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1139: Missing.
     1140-1140: E → M

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,263
Checksum:i46B36F8248128C3F
GO
Isoform 6 (identifier: Q5THR3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-420: KPD → VRF
     421-1501: Missing.

Note: No experimental confirmation available.
Show »
Length:420
Mass (Da):48,464
Checksum:iCC793F6A57192EA9
GO
Isoform 5 (identifier: Q5THR3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1217-1249: FDRLWNEMPVNAKGRLKYPDFLSRFSSETAATP → VRNASQSSPCTPLAERQPGPWPECTEFKTVLYF
     1250-1501: Missing.

Note: No experimental confirmation available.
Show »
Length:1,249
Mass (Da):144,276
Checksum:iD35F8F03F7772E08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti478S → P in BAF85187 (PubMed:14702039).Curated1
Sequence conflicti726I → V in BAF85187 (PubMed:14702039).Curated1
Sequence conflicti833A → V in BAF85187 (PubMed:14702039).Curated1
Sequence conflicti882P → S in BAF85100 (PubMed:14702039).Curated1
Sequence conflicti990Q → H in BAB71780 (PubMed:12612053).Curated1
Sequence conflicti990Q → H in BAB15703 (PubMed:14702039).Curated1
Sequence conflicti1082D → G in AAH39315 (PubMed:15489334).Curated1
Sequence conflicti1139E → G in BAF85100 (PubMed:14702039).Curated1
Sequence conflicti1182T → P in BAF85187 (PubMed:14702039).Curated1
Sequence conflicti1218D → G in AAH39315 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048648166V → A.Corresponds to variant rs16990981dbSNPEnsembl.1
Natural variantiVAR_048649199R → G.Corresponds to variant rs3747203dbSNPEnsembl.1
Natural variantiVAR_048650351T → A.1 PublicationCorresponds to variant rs5764214dbSNPEnsembl.1
Natural variantiVAR_048651384S → A.Corresponds to variant rs6006438dbSNPEnsembl.1
Natural variantiVAR_048652400H → Y.1 PublicationCorresponds to variant rs137794dbSNPEnsembl.1
Natural variantiVAR_048653680T → A.1 PublicationCorresponds to variant rs137731dbSNPEnsembl.1
Natural variantiVAR_048654780D → N.Corresponds to variant rs12159591dbSNPEnsembl.1
Natural variantiVAR_048655800R → W.Corresponds to variant rs6006514dbSNPEnsembl.1
Natural variantiVAR_0486561059A → V.3 PublicationsCorresponds to variant rs9614382dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0198081 – 1139Missing in isoform 4. 1 PublicationAdd BLAST1139
Alternative sequenceiVSP_0198091 – 931Missing in isoform 3. 2 PublicationsAdd BLAST931
Alternative sequenceiVSP_0198101 – 152Missing in isoform 2. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_034831418 – 420KPD → VRF in isoform 6. Curated3
Alternative sequenceiVSP_034832421 – 1501Missing in isoform 6. CuratedAdd BLAST1081
Alternative sequenceiVSP_0198111140E → M in isoform 4. 1 Publication1
Alternative sequenceiVSP_0198121217 – 1249FDRLW…TAATP → VRNASQSSPCTPLAERQPGP WPECTEFKTVLYF in isoform 5. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0198131250 – 1501Missing in isoform 5. 1 PublicationAdd BLAST252

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073862 mRNA. Translation: BAB71780.1.
AK027241 mRNA. Translation: BAB15703.1.
AK292411 mRNA. Translation: BAF85100.1.
AK292498 mRNA. Translation: BAF85187.1.
AL355841 mRNA. Translation: CAB91065.1.
Z82201
, AL023801, AL031843, AL118498, Z97055 Genomic DNA. Translation: CAQ07046.1.
Z82201, AL023801, Z97055 Genomic DNA. Translation: CAQ07047.1.
Z97055
, AL023801, AL031843, AL118498, Z82201 Genomic DNA. Translation: CAQ09926.1.
Z97055, AL023801, Z82201 Genomic DNA. Translation: CAQ09928.1.
AL023801
, AL031843, AL118498, Z82201, Z97055 Genomic DNA. Translation: CAQ10020.1.
AL023801, Z82201, Z97055 Genomic DNA. Translation: CAQ10022.1.
AL031843
, AL023801, AL118498, Z82201, Z97055 Genomic DNA. Translation: CAQ10334.1.
AL118498
, AL023801, AL031843, Z82201, Z97055 Genomic DNA. Translation: CAQ11050.1.
BC039315 mRNA. Translation: AAH39315.1.
AB051459 mRNA. Translation: BAB33342.1.
CCDSiCCDS14049.1. [Q5THR3-1]
CCDS14050.1. [Q5THR3-2]
RefSeqiNP_073622.2. NM_022785.3. [Q5THR3-1]
NP_942153.1. NM_198856.2. [Q5THR3-2]
UniGeneiHs.658996.

Genome annotation databases

EnsembliENST00000262726; ENSP00000262726; ENSG00000186976. [Q5THR3-1]
ENST00000396231; ENSP00000379533; ENSG00000186976. [Q5THR3-2]
GeneIDi64800.
KEGGihsa:64800.
UCSCiuc003bdy.3. human. [Q5THR3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073862 mRNA. Translation: BAB71780.1.
AK027241 mRNA. Translation: BAB15703.1.
AK292411 mRNA. Translation: BAF85100.1.
AK292498 mRNA. Translation: BAF85187.1.
AL355841 mRNA. Translation: CAB91065.1.
Z82201
, AL023801, AL031843, AL118498, Z97055 Genomic DNA. Translation: CAQ07046.1.
Z82201, AL023801, Z97055 Genomic DNA. Translation: CAQ07047.1.
Z97055
, AL023801, AL031843, AL118498, Z82201 Genomic DNA. Translation: CAQ09926.1.
Z97055, AL023801, Z82201 Genomic DNA. Translation: CAQ09928.1.
AL023801
, AL031843, AL118498, Z82201, Z97055 Genomic DNA. Translation: CAQ10020.1.
AL023801, Z82201, Z97055 Genomic DNA. Translation: CAQ10022.1.
AL031843
, AL023801, AL118498, Z82201, Z97055 Genomic DNA. Translation: CAQ10334.1.
AL118498
, AL023801, AL031843, Z82201, Z97055 Genomic DNA. Translation: CAQ11050.1.
BC039315 mRNA. Translation: AAH39315.1.
AB051459 mRNA. Translation: BAB33342.1.
CCDSiCCDS14049.1. [Q5THR3-1]
CCDS14050.1. [Q5THR3-2]
RefSeqiNP_073622.2. NM_022785.3. [Q5THR3-1]
NP_942153.1. NM_198856.2. [Q5THR3-2]
UniGeneiHs.658996.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WLZX-ray1.60A/B/C/D1160-1260[»]
5D67X-ray2.00A/B/C/D1160-1260[»]
ProteinModelPortaliQ5THR3.
SMRiQ5THR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122306. 4 interactors.
IntActiQ5THR3. 1 interactor.
STRINGi9606.ENSP00000262726.

PTM databases

iPTMnetiQ5THR3.
PhosphoSitePlusiQ5THR3.

Polymorphism and mutation databases

BioMutaiEFCAB6.
DMDMi74756634.

Proteomic databases

EPDiQ5THR3.
PaxDbiQ5THR3.
PeptideAtlasiQ5THR3.
PRIDEiQ5THR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262726; ENSP00000262726; ENSG00000186976. [Q5THR3-1]
ENST00000396231; ENSP00000379533; ENSG00000186976. [Q5THR3-2]
GeneIDi64800.
KEGGihsa:64800.
UCSCiuc003bdy.3. human. [Q5THR3-1]

Organism-specific databases

CTDi64800.
GeneCardsiEFCAB6.
H-InvDBHIX0016558.
HGNCiHGNC:24204. EFCAB6.
HPAiHPA003098.
HPA018946.
neXtProtiNX_Q5THR3.
OpenTargetsiENSG00000186976.
PharmGKBiPA162384324.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013629.
HOVERGENiHBG095997.
InParanoidiQ5THR3.
OMAiVLKDFCY.
OrthoDBiEOG091G0TP8.
PhylomeDBiQ5THR3.
TreeFamiTF329179.

Miscellaneous databases

ChiTaRSiEFCAB6. human.
EvolutionaryTraceiQ5THR3.
GeneWikiiEFCAB6.
GenomeRNAii64800.
PROiQ5THR3.

Gene expression databases

BgeeiENSG00000186976.
CleanExiHS_EFCAB6.
ExpressionAtlasiQ5THR3. baseline and differential.
GenevisibleiQ5THR3. HS.

Family and domain databases

Gene3Di1.10.238.10. 12 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR015070. EF_hand_DJBP.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF08976. EF-hand_11. 2 hits.
PF13833. EF-hand_8. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 12 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 13 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFCB6_HUMAN
AccessioniPrimary (citable) accession number: Q5THR3
Secondary accession number(s): A8K8P6
, A8K8Y3, B0QYI4, B0QYI6, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.