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Protein
Submitted name:

Prolactin

Gene

PRL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHormoneUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
ProlactinImported
Gene namesi
Name:PRLImported
ORF Names:hCG_36753Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000172179.11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33790

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501430996529 – 227Sequence analysisAdd BLAST199

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000172179
ExpressionAtlasiQ5THQ0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5THQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410II74 Eukaryota
ENOG410XU1S LUCA
HOVERGENiHBG104895
KOiK05439

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5THQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIKGSPWKG SLLLLLVSNL LLCQSVAPLP ICPGGAARCQ VTLRDLFDRA
60 70 80 90 100
VVLSHYIHNL SSEMFSEFDK RYTHGRGFIT KAINSCHTSS LATPEDKEQA
110 120 130 140 150
QQMNQKDFLS LIVSILRSWN EPLYHLVTEV RGMQEAPEAI LSKAVEIEEQ
160 170 180 190 200
TKRLLEGMEL IVSQVHPETK ENEIYPVWSG LPSLQMADEE SRLSAYYNLL
210 220
HCLRRDSHKI DNYLKLLKCR IIHNNNC
Length:227
Mass (Da):25,876
Last modified:May 10, 2005 - v1
Checksum:i952BBA1B6A955527
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ305133 mRNA Translation: ACT52574.1
CH471087 Genomic DNA Translation: EAW55435.1
RefSeqiNP_000939.1, NM_000948.5
NP_001157030.1, NM_001163558.2
UniGeneiHs.1905
Hs.735971

Genome annotation databases

GeneIDi5617
KEGGihsa:5617
UCSCiuc003ndp.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5THQ0_HUMAN
AccessioniPrimary (citable) accession number: Q5THQ0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health